The current practice of real-time hybrid simulation (RTHS) often requires specialized finite element programs for computational modeling of the analytical substructures. Considering the limited nonlinear modeling capacity or the increasing computation cost for complex modeling, surrogate models of the analytical substructure provide novel alternatives for RTHS to avoid finite element analysis with fast computation. This study explores the use of arbitrary polynomial chaos expansion (APC) and nonlinear autoregressive with exogenous input (NARX) model to emulate the dynamic behavior of analytical substructures in RTHS. The NARX model training can be conducted numerically in an off-line mode using existing general purpose finite element analysis software, and its implementation presents minimum computational demands on the RTHS equipment. RTHS of a single-degree-of-freedom structure with a self-centering viscous damper is conducted as proof of concept to experimentally demonstrate the effectiveness and superiority of the proposed APC-NARX-based approach. The APC is further compared with other metamodeling techniques including polynomial chaos expansion (PCE) and Kriging to surrogate NARX model coefficients to account for ground motion uncertainties in RTHS. It is demonstrated that APC-NARX modeling with optimal order enables better accuracy of RTHS results than those of Kriging- and PCE-NARX.