Experimental results for the difluoromethane (R32) + nitrous oxide (N2O) system are presented in this paper. The Burnett apparatus was calibrated using helium, and its performance was confirmed by measurements for pure N 2O. The values of the virial coefficients for R32 were adopted from previous measurements as the same sample was used in the present study. PVTx measurements were performed for the binary R32 + N2O system for four isotherms (303, 323, 343, and 364 K). Twenty Burnett expansions were performed in a pressure range from 5000 to 150 kPa. The second and third virial coefficients along with the cross second and third virial coefficients were derived from experimental results.