Effect of maximum test temperature on crack propagation behavior of an Austenitic cast steel during Thermo-Mechanical Fatigue (TMF) tests was explored under the In-Phase(IP) and Out-of-Phase(OP) conditions. The behavior was comprared with that of isothermal low cycle fatigue. The experimental results clearly showed that additional mechanism(s) mechanism to pure fatigue begun to work, when the maximum temperature get higher enough. It was also shown that not only the mechanical factors but the microstuructural features;e.g., microsegragation around dendritic boundaries, played an important role in the crack progation process.