Pure Ethanol Injection Research Articles

内視鏡的純エタノール局注が奏効した扁平上皮癌のポリープ状発育による気管閉塞の 1 例

内視鏡的純エタノール局注が奏効した扁平上皮癌のポリープ状発育による気管閉塞の 1 例

エタノール局注止血が有効であった放射線照射性腸炎の1例

エタノール局注止血が有効であった放射線照射性腸炎の1例

Evaluation of Endoscopic Hemostasis by Local Injection of Pure Ethanol for Bleeding Peptic Ulcer

Evaluation of Endoscopic Hemostasis by Local Injection of Pure Ethanol for Bleeding Peptic Ulcer

Long-term follow-up after intracoronary ethanol ablation of atrioventricular conduction

Recently we reported on the chemical ablation of atrioventricular (AY) conduction by selective injection of pure ethanol into the AV nodal coronary artery. 1 In this communication we would like to report on the long-term follow-up of this intervention in 11 patients.

Comparative study of low power neodymium-YAG laser interstitial hyperthermia versus ethanol injection for controlled hepatic tissue destruction

A solitary hepatic metastasis is amenable to surgery. However, if surgery is contraindicated or if multiple lesions are present in both liver lobes, other treatment modalities have to be considered. We compared the effect of interstitial laser hyperthermia with damage caused by alcoholization. Six anaesthetized beagle dogs were studied. Three animals were treated with laser hyperthermia. A bare laser fibre (400μm diameter) was introduced through a 17-gauge needle, length 170 mm, positioned into the liver under real time ultrasonographic guidance. Lesions were produced by continuous 500-s exposure of 1W YAG laser (Medilas MBB 40N) power. Three dogs were subjected to an injection of 4 ml of 98% pure ethanol into the liver through the same needle system. Two days after the procedure the animals were killed and the livers examined. The surface of the livers treated with the YAG laser were entirely normal; superficial lesions were, however, clearly visible. Laserinduced lesions were well reproducible, clearly demarcated, roughly spherical with a mean diameter of 1.01±0.23 cm (n=16). In contrast, the dogs treated with alcohol had free intraperitoneal serohaemorrhagic fluid and the surface of the liver was diffusely abnormal. The lesions had a more or less cylindrical shape, 1.22±0.43 cm on 0.40±0.10 cm (n=12) although exact measurement was often difficult. The border of the lesions was irregular and there was a clear necrotic zone along the puncture track. On microscopic examination the laser-induced lesions consisted of a central evaporation area, a zone of carbonized material and an outer zone of coagulation necrosis. The alcohol-induced lesions were characterized by both ‘fixation’ necrosis and coagulative necrosis but surprisingly, there was also necrosis present at a distance of the lesions extending along the centrilobular and even portal veins. These data show that laser-induced interstitial necrosis in the liver is better controlled and more reproducible than necrosis induced by injection of pure ethanol. Moreover, pure ethanol may cause damage to the liver surface and even at a distance of the injection site.

気管内肉芽に対する純エタノール局注療法の試み

A 60-year-old man was admitted to a hospital with infarction of the brain stem. Tracheostomy was done and he had breathed through a cuffed tracheal canula for five months. And then, he suffered from suffocation due to growth of polyp like granulation tissue when the canula was exchanged. We tried pure ethanol injection via a flexible bronchofiberscopy to the granulation tissue. The airway obstruction was improved. We thought intratumoral ethanol injection was one of the useful treatment for unfavourable development of the granulation after tracheostomy.

EXULCERATIO SIMPLEX (Es) AND Es-LIKE LESION

A diagnosis of Exulceratio simplex (Es) or Es-like lesion has recently been made under endoscopic observation. Treatment, i.e. hemostasis, is also often done endoscopically. Reports on a follow-up study after endoscopic manegement, however, are extremely rare. Therefore, clinical value of endoscopic manegement for Es is still unknown. This paper reports on a follow-up study of endoscopic treatment for 16 cases of Es and Es-like lesion. In 3 out of 16 cases, operative hemostasis was performed; each one underwent subtotal gastrectomy, wedge resection of the bleeding point, and simple closure of the bleeding artery, respectively. All of the other 13 cases were successfully treated with endoscopic hemostasis. i.e. local injection of pure ethanol (ETH method). Four not of these 13 cases died of preexisting severe complications but not of recurrence of Es. There is no sign of recurrence in the remained 9 cases during the observation periods ranging from 25 to 59 months. These results indicate a clinical significance of endoscopic hemostasis of Es and Es-like lesion.

Indications and Limits of Endoscopic Hemostatic Method of Local Pure Ethanol Injection for Gastro-duodenal Ulcer Bleedings

Indications and Limits of Endoscopic Hemostatic Method of Local Pure Ethanol Injection for Gastro-duodenal Ulcer Bleedings

Endoscopic diagnosis and treatment of Dieulafoy's ulcer.

Dieulafoy's ulcer often develops unmanageable severe gastrointestinal hemorrhage and sometimes takes a fatal course. In the past surgical operations were considered to be the only life-saving measure for this lesion. Since 1979, 46 lesions of Dieulafoy's ulcer in 45 cases with active bleeding from exposed blood vessels were treated during emergency endoscopy by the hemostatic method of pure ethanol injection. Transient hemostasis was obtained in all cases. Rebleeding occurred in 5 cases (11%) and pure ethanol injection was performed again. Hemostasis was obtained in all cases, but one case again had rebleeding due to an overlooked Dieulafoy's ulcer located in the gastric fundus. Emergent surgical operation was performed in this case. No case required elective surgery and no deaths were attributed to bleeding. Our method achieved complete hemostasis at a rate of 98% (44 cases) for Dieulafoy's ulcer. The pure ethanol injection method is one of the most effective hemostatic methods for the Dieulafoy's ulcer.

A case of a para bile duct lymphcyst with polycystic disease. A para bile duct lymphcyst which was treated with pure ethanol injection after ultrasonic dranage.

A case of a para bile duct lymphcyst with polycystic disease. A para bile duct lymphcyst which was treated with pure ethanol injection after ultrasonic dranage.

純エタノール局注療法により止血治癒し得たDieulafoy'stypeと思われる十二指腸潰瘍の1例

純エタノール局注療法により止血治癒し得たDieulafoy'stypeと思われる十二指腸潰瘍の1例

Hemostatic effect of pure ethanol injection through fiberoptic colonoscope on hemorrhage after polypectomy

Hemostatic effect of pure ethanol injection through fiberoptic colonoscope on hemorrhage after polypectomy

Endoscopical polypectomy using high frequency current: double-snare method of polypectomy for prevention of incidental bleeding and perforation.

The author developed a double-snare method or high-frequency-current-applied endoscopical polypectomy (double-snare polypectomy, for short). Since 1975 the double-snare polypectomy was applied to 40 gastric polyps (36 patients), over 15 mm in the largest diameter. 7 massively hemorrhaged cases after polypectomy were treated by hemostatic methods, such as electrocoagulation and pure ethanol injection. This method was warranted as a reliable formula for a risk-less resection of large polyps without causing persistent major bleeding or fateful perforation.