This study unveils an innovative approach to fabricating H2S gas sensor prototypes for continuous monitoring, leveraging Pd-decorated CuCrO2-based metal oxide semiconductor (MOS) chemiresistors and artificial neural network-assisted impedance-based multivariate analysis. Sensors were exposed to H2S in cross-interfering environments containing humidity, NO2, NH3, CH4, H2, and CO2. Impedance-based parameters (Z, phase difference, Z′ and Z") obtained at various frequencies demonstrated that sensors were reproducible and selective for H2S detection. A neural network-based multilayer perceptron (MLP) regression model was trained with different impedance-based parameters to estimate the H2S concentrations. Continuous operation resulted in larger baseline variation for Z, Z′, and Z" readings; however, the measured phase difference values exhibited less depletion than other parameters. Furthermore, concerns about baseline changes were effectively addressed with a fine-tuned MLP model, which predicted both pure air and H2S atmospheres more correctly under cross-interfering and baseline-depleted conditions by employing phase differences at different frequencies as input. Possible reasons for the accurate prediction can be attributed to the confined behaviour of phase difference and discussed with the help of sensor statistical parameters such as mean variation, standard deviation and principal components.