Aims/Purpose: Current myopia control contact lenses (CLs) are based on multifocality designs that affect decrease retinal image quality (RIQ). This study aimed to evaluate the changes in RIQ and accommodative response (AR) with two myopia control CLs.Methods: 100 synthetic eyes were generated using anc accommodative wavefront model to simulate the changes in RIQ with accommodation. The synthetic eyes were “fitted”, using direct wavefront summation, with two myopia control CLs: the MiSight with +2.00D treatment zones and the Mylo with an EDOF design. Peak image quality was calculated for the naked eye and with CLs, in the relaxed state and a target vergence of 40 cm, with an entrance pupil diameter of 4.28 mm. Additionally, the AR that maximizes RIQ was calculated.Results: The mean RIQ [ranged from 0 to 1] for the relaxed eye was 0.42 ± 0.10 without a CLs. It halved to 0.26 ± 0.05 with the Misight and reduced by threefold to 0.15 ± 0.04 with the Mylo. For 40cm the RIQ was 0.34 ± 0.09 without a CL, 0.24 ± 0.07 with the Misight and 0.19 ± 0.03 with the Mylo.For target vergences with demands close the effective add power of the CL, the accommodative RIQ through‐focus produced a second peak prior to the maximum peak, correspondent to the focusing power of the treatment zones1, yielding a RIQ of 0.08 ± 0.03 and 0.12 ± 0.04 for the Misight and Mylo, respectively. The AR without CL was 2.33 ± 0.20 D, 1.75 ± 0.22 D and 1.75 ± 0.22 D with the Misight and the Mylo, respectively.Conclusions: Both myopia control CLs reduced the RIQ in the relaxed and accommodated states. For 40 cm, both CLs induce a secondary peak in the RIQ through‐focus. With Mylo, the secondary peak appeared less than 0.1D from the maximum peak, possibly due to its EDOF design. The AR was reduced with both CLs 0.58 D (lag) compared to the naked eye condition. These results indicate that, both lenses impose significant limitations RIQ and AR.
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