The management of post-irradiation ulcers is one of the most perplexing problems confronting radiotherapists and dermatologists. Such lesions are usually punched-out ulcers, the walls of which are composed of thick ischemic fibrous tissue. The ulceration itself represents the area of greatest ischemia. Local vascularity is at a minimum, the blood vessels showing marked sclerosis of the intimal, medial, and muscular coats. These tissues, then, are deprived of their normal capacity for growth and repair and therein lies the difficulty of accomplishing the healing of such lesions. Numerous conservative, non-surgical methods of treating post-irradiation ulcerations have been tried. Among the agents employed are ultraviolet radiation (1), the aloe vera leaf (2), ointment containing pancreatic ferments (3), radium, and an assortment of salves. The results of treatment with these non-surgical methods have not been satisfactory. Conway (4) concludes that conservative measures are of little value in the eradication of necroses following roentgen and radium therapy and that these lesions must be treated by surgical intervention. Surgery, however, must be radical and is often attended by poor cosmetic results. Moreover, not every patient will consent to operation. In view of these circumstances, the virtues of any other proposed conservative method of treatment should be carefully appraised. Sellers (5) recently reported three cases of “x-ray burns” in which local application of estrogenic hormone in oil yielded excellent results. One of the patients was the author himself. He and one of his patients—both with ulcers of the fingers following overexposure to roentgen rays—had undergone the full gamut of ointment applications, “with but slight avail.” After ten months of unsuccessful treatment, estrogenic hormone in oil solution was applied to the crater of the ulcerations three to six times a day. Improvement was noticeable within fifteen days. Subsequently, sesame oil was used as a control without visible results. Finally, after thirty days of continuous application of estrogenic hormone, the lesions healed. In the third patient, with a roentgen-ray ulcer of the left index finger, treatment with estrogenic hormone for two months resulted in complete healing. Another favorable report along these lines is that of Wagner (6). He treated 7 patients with roentgen-ray ulcers—3 men ranging in age between thirty-five and seventy and 4 women between forty-four and seventy years of age—with an ointment containing synthetic estrogen, applying this locally every day to the resistant lesions. This therapy resulted in 2 cures, while 5 patients were greatly improved. Wagner observed formation of granulation tissue and beginning epithelization under the influence of the hormone ointment. Encouraged by these reports, particularly the article by Sellers, we decided to place on estrogenic therapy two cases of severe post-irradiation necrosis which were under our care.