Processes of crystal-mush remobilization by mafic magma recharges are often related to the outpouring of large volumes of silicic melt during caldera-forming eruptions. This occurred for the Campanian Ignimbrite (CI) eruption (Campi Flegrei, Italy), which produced a voluminous trachy-phonolitic ignimbrite in southern-central Italy about 40 ka ago. We focussed on the proximal-CI deposits at San Martino that are composed of a main sequence of early-erupted, crystal-poor units and a late-erupted (post-caldera collapse) crystal-rich Upper Pumice Flow Unit (UPFU). Detailed micro-analytical geochemical data were performed on glasses and crystals of pyroclasts from these deposits and coupled with Sr-Nd isotopic measurements on glasses. Results show that the CI eruption was fed by two distinct melts for the early-erupted units and the late UPFU, respectively. The glasses of the early-erupted units have negative Eu anomalies and show more evolved compositions and higher Nd isotope ratios than those of the UPFU, which have positive Eu/Eu*. The magmas of the early units formed the main volume of eruptible melt of the CI reservoir, and are interpreted as having been extracted from cumulate crystal-mush without a vertical geochemical gradient within the magma reservoir. The data indicate that the generation of the distinctive UPFU melts involved the injection of a new batch of mafic magma into the base of the CI reservoir. The mafic magma allowed heating and reactivation of the CI crystal-mush by melting of low-Or sanidines (+/− low-An plagioclases), leaving high-An plagioclases and high-Mg# clinopyroxenes as residual phases and a crystal-mush melt, made of 20% of the initial mush interstitial melt (with a composition similar to the early-erupted units) and 80% of sanidine melt. When the mush crystallinity was sufficiently reduced, the mafic magma was able to penetrate into the reactivated crystal-mush, mixing with variable proportions of crystal-mush melt and generating cooler hybrid melts, which underwent further crystallization of high-Or sanidine at variable degrees (10–25%). Finally, possibly a short time before the eruption, the UPFU magmas were able to mix and mingle with the crystal-poor eruptible melts still persisting in the CI reservoir at the time of UPFU emission. We suggest that the complex mechanisms described for the magma evolution feeding the CI eruption may occur whenever a crystal-mush is reactivated by new mafic magma inputs