Review question/objective The objective of this review is to investigate if laser treatments can effectively treat onychomycosis of the nails in healthy adults living in the community. More specifically, the objectives are to identify: whether the investigated experimental methods, modes and treatment regimens utilizing laser interventions, applied to adults (> 18 years) living in the community with at least one nail infected with onychomycosis, produce outcomes comparable to the current 'gold standard treatment' of oral terbinafine over a minimum 12-week treatment period. Inclusion criteria Types of participants This review will consider studies that include males and females over the age of 18 years who have at least one nail with diagnosed onychomycosis using fungal culture, and direct microscopy, KOH method or periodic acid-Schiff (PAS).Males and females over the age of 18 years with diagnosed diabetes, HIV, cancer, transplant recipients and pregnant females will be excluded. Types of intervention(s)/phenomena of interest Studies that evaluate types of laser therapy for the treatment of onychomycosis including but not limited to; long pulse Nd:YAG laser, Flashlamp pumped short pulsed Nd:YAG 1064nm, 1320nm Nd:YAG laser, modelocked femtosecond pulsed Ti:Sapphire laser, near infra-red Diode lasers, low level laser light treatment inclusive of dose duration and frequency. Types of outcomes This review will consider studies that include the following outcome measures: Primary outcome is cure or clinical response. Cure is defined as positive: 1. Clear nail growth (CNG) defined by at least 3mm growth in three to 12 months, or 2. No dermatophyte isolated from nail samples grown on a mycological culture medium, and 3. Absence of microscopically detectable fungal elements from nail samples treated with KOH, or 4. Absence of microscopically detectable fungal elements using PAS stain, or 5.100% normal nail appearance in three to 18 months plus negative culture and microscopic results. Secondary Outcomes: Compliance rate measured by client attendance for treatments. Recurrence as identified at follow-up at six and/or 12months minimum timeframe. Presence or absence of adverse effects. Adverse affects include skin irritation (erythema) adjacent to the treated nails, nail bed irritation, nail discoloration, onycholysis and periungual burning sensation. Client satisfaction with treatment outcome.