After dental replantation surgery, it is necessary to take measures to promote the healing of the replanted tooth. In almost 100% of cases, clear signs of an acute inflammatory reaction of periodontal tissues are diagnosed. The effectiveness of combined preparation and pharmacological therapy in the prevention of the inflammatory process of periodontal tissues after tooth replantation was assessed. The condition of the periodontal mucosa and periodontal ligamentous apparatus in the area of supporting teeth was studied in preparation for orthopedic treatment of dentition defects, after the operation of their dental replantation. To solve the set tasks, research methods were used in the work: visual, palpation, instrumental, and statistical analysis of the research results. The patients are divided into two groups. Drug therapy was carried out using traditional medications: antiseptics, antibacterial drugs, biogenic stimulants, etc. Drug therapy used to treat patients in group 1 and group 2 was identical in the list of medications used. Patients of the 2nd group underwent complex treatment of inflammatory phenomena of the desmodontal structures and periodontal mucosa that occur after replantation surgery. In addition to pharmacological drugs, exposure to modulated red light was used using a Stomasvet physiotherapeutic device with a wavelength of 328 nm, a pulse modulation frequency of 76 Hz, and a radiation power of up to 30 mW. On the first day of the study, patients of group 1 and group 2 were characterized by hyperemia of the periodontal mucosa in the area of the replantation, swelling, and pain. By the fourth day, in patients of group 2, the inflammatory phenomena completely disappeared. In patients of group 1, inflammatory phenomena completely disappeared only by the eighth day. An integrated approach to the diagnosis and treatment of periodontal pathologies that arise after dental replantation will reduce the preparatory period for subsequent orthopedic correction of dentition defects, reduce the duration of patient adaptation to the structures used, and also increase the overall level of orthopedic treatment in dentistry.