Due to the lack of comparative studies between discontinuous pulse-width modulation and model predictive control methods for reducing switching losses in two-level three-phase voltage source inverter, a comparative analysis of a generalized discontinuous pulse-width modulation and two model predictive control approaches for reducing switching losses is studied in this paper. Both generalized discontinuous pulse-width modulation and two model predictive control approaches are described and conducted in the simulation and experiment. The output performance is obtained by these methods after conducting in various conditions, including switching frequency, output power, and load conditions. It is validated that the generalized discontinuous pulse-width modulation control scheme achieves a better control performance at steady-state, while two model predictive control schemes have better transient-state performance with a superior dynamic. Additionally, the generalized discontinuous pulse-width modulation approach achieves better reducing switching losses performance and has slightly higher efficiency than that of two model predictive control approaches.