The 2.7 W/4.2 K two-stage pulse tube cryocooler (Model PT425) was developed and introduced by Cryomech, Inc. in 2021, which, at the time, was the largest, commercially available, 4 K pulse tube cryocooler. Our newest model, the PT450, has been successfully developed, providing a minimum of 5.0 W at 4.2 K on the 2nd stage with 65 W at 45 K on the 1st stage simultaneously, operating on either 60 or 50 Hz power. The PT450 answers the market’s need for the continuing development of large cryogen-free dilution refrigerators, superconducting magnets, helium liquefiers and other applications requiring large cooling capacities at 4 K.In addition, a new helium compressor (Cryomech CPA3027) has also been developed to provide sufficient helium flow for the PT450 and other large cooling power cryocoolers. This new model also allows multiple cryocoolers to operate on one compressor. The CPA3027 is the largest commercially available helium compressor for the Gifford-McMahon and pulse tube cryocooler market.The system configuration and main cooling performance of the PT450 cold head will be presented in this paper.