Porcelain cylindrical electrical equipment (PCEEs), such as potential and current transformers, are critical components of electrical substations and essential to power supply networks. Nevertheless, previous strong earthquakes have rendered high vulnerability and poor performance of PCEE during seismic occurrences. To improve seismic performance of PCEE and alleviate adverse seismic impacts, an innovative synergistic mitigation method based on base isolation (BI) and tuned mass damper (TMD) was proposed and subsequently employed to PCEE. Combining BI with TMD allows for a greater utilization of each technology’s capabilities while also circumventing some of the limits of each. While TMD effectiveness is sensitive to input ground motion frequencies, BI could act as a filter to tune input frequency and help TMD fulfill better damping effectiveness. TMD could in return help BI achieve better stability under long-period dominant or pulse-like ground motions. The BI-TMD effectiveness and robustness were investigated using finite element modeling and nonlinear time history analysis. A comprehensive parametric study that considers variable PCEE frequencies, BI periods, TMD mass ratios, and TMD control frequencies was conducted. Results show that the proposed BI-TMD method can significantly enhance the effectiveness and robustness beyond BI single control in mitigating seismic responses of PCEE.