Pulpotomy Medicament In Primary Teeth Research Articles

COMPARATIVE EVALUATION OF 3MIXTATIN WITH MTA AND FORMOCRESOL FOR PULPOTOMY OF PRIMARY MOLARS: AN IN-VIVO STUDY

Background- Preservation of pulp vitality is of utmost importance to the normal physiological functioning of tooth in situ and physiological process of exfoliation in a tooth affected by disease or trauma. Pulpotomy serves such a purpose using various medicaments applied directly on vital pulp. Aim- To compare and evaluate the clinical and radiographic success of 3Mixtatin with MTA and formocresol for pulpotomy of primary molars. Materials & Methodology– Sixty primary molars were selected from 100 children aged between 5-9 years age who reported to Department of Pedodontics and Preventive Dentistry. All selected primary teeth were randomly divided in to three groups with 20 each depending on the type of pulpotomy medicament (Group I - Formocresol, Group II - MTA, Group III -3mixtatin) used. The children were then examined clinically and radiographically at 6 and 12 months. Results & Observation– Overall clinical and radiographic success rate of three groups at 6 months and 12 months were Group I showed success rate of 91.7 percent ,81.7 percent Group II showed 100percent, 91.7percent Group III showed 95 percent,85 percent respectively. Conclusion– 3mixtatin can be considered as additional pulpotomy medicament in primary teeth because of its bio-compatible and bioinductive properties.

Turmeric Gel as alternative Non-Vital Pulpotomy medicament in Primary teeth- A Randomized Controlled Trial

<p><strong>Background and objective: </strong>Formocresol is a gold standard medicament in both vital and non-vital Pulpotomies due to its potent antibacterial potential but, it has a controversial nature due to its side effects. Therefore, the demand for natural alternatives of Formocresol as a pulp dressing material, with few or no side effects, became imperative. The purpose of the study was to introduce Turmeric gel as non-vital Pulpotomy medicament in primary teeth by evaluating its antibacterial effect against<em> Streptococcus mutans</em> and <em>Lactobacillus acidophilus</em>.</p>
 <p><strong>Method: </strong>It was a multi-arm parallel Randomized Controlled Trial in which sixty patients aged between 4 to 8 years, each containing at-least one non-vital primary molar, were selected and randomly divided into Group A (Formocresol) and Group B (Turmeric gel). Non-vital Pulpotomy was performed by removing the coronal necrotic pulp. Sterile paper points were dipped in the root canals and taken to the laboratory. Cotton pellets soaked in the respective medicaments were placed over the root canal orifices and filled temporarily. Patients were recalled after one week. Samples were again taken, and tooth restored. Comparison between bacterial count at baseline and after one week of treatment was made and expressed as Colony-Forming Units/ml (CFU/ml).</p>
 <p><strong>Results:</strong> There was a significant reduction in median <em>Streptococcus mutans</em> and <em>Lactobacillus acidophilus</em> bacterial count in each group after one week of treatment (p < 0.001). Formocresol showed higher average reduction than Turmeric gel. However, statistically, the difference was insignificant indicating that both the medicaments possessed comparable antibacterial effect.</p>
 <p><strong>Conclusion:</strong> Turmeric gel was found as effective alternative to Formocresol.</p>
 <p><strong>Randomized Controlled Trial registration number in ClinicalTrials.gov:</strong> NCT05801354</p>
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Clinical and Radiographic Evaluation of Nigella sativa and Aloe vera as Pulpotomy Medicaments in Primary Teeth: A Randomized Controlled Trial

Clinical and Radiographic Evaluation of Nigella sativa and Aloe vera as Pulpotomy Medicaments in Primary Teeth: A Randomized Controlled Trial

A histopathological comparison of formocresol, propolis, and growth factor as pulpotomy medicaments in primary teeth: An in vivo study

Pulpotomy is the most common pulp treatment of primary molars, where surgical amputation of infected coronal pulp results in preserving the vitality and function of radicular pulp. With introduction of newer materials, the emphasis has shifted towards regeneration, in this scenario; novel materials such as platelet derived growth factor (PDGF) and propolis (PS) have been considered. This was a single-blind in vivo study; ninety human primary teeth from children aged between 5 and 10 years were divided into three equal groups in whom pulpotomy procedure was performed and they were recalled after 3- and 6-month interval for histological evaluation. Observations were subjected to statistical analysis using Pearson's Chi-square test. No statistically significant difference was found between the three materials with respect to inflammatory response, soft-tissue organization, and dentin bridge formation (P > 0.05). Majority of the samples in both growth factor and propolis exhibited dentin bridges at the interface of the exposed pulp, bringing or attempting to bridge the site exposed to the pulpotomy material. The ability of the material to evoke a foreign and inflammatory cell response in the pulpal tissue was not significant. The samples of both formocresol and growth factor group showed signs of pulpal necrosis which revealed the presence of a mild necrotic zone in one specimen at 3 months. One specimen from the propolis group showed mild areas of necrosis at the end of 6 months, where none of the specimens in the growth factor group showed areas of necrosis at the end of 6 months. The results of the present study showed a positive outcome for growth factor and propolis groups. Further clinical trials with a larger sample size and long-term review have to be conducted for the material to be used widely.

Efficacy of Biodentine versus formocresol in pulpotomy of primary teeth: a systematic review and meta-analysis.

To systematically evaluate and meta-analyze the short-and long-term clinical and radiologic failure rates of Biodentine versus formocresol as pulpotomy medicaments in primary teeth. Relevant medical databases were searched until May 2021 for randomized controlled trials that used Biodentine and formocresol as pulpotomy medicaments in primary teeth with deep caries. Primary outcomes included clinical and radiologic failure rates at 12 months. Secondary outcomes were clinical and radiologic failure rates at 3, 6, 9, 13 to 24, and 25 to 48 months. Nine randomized controlled trials (N = 626) with low risk of bias were included. Pooled analysis showed that compared to formocresol, Biodentine had significantly lower clinical failure rates (relative risk [RR] 0.16; 95% confidence interval (CI) 0.03 to 0.87; six randomized controlled trials; N = 394; GRADE, low) and radiologic failure rates (RR 0.19; 95% CI 0.08 to 0.49; six randomized controlled trials; N = 393; GRADE, low) at 12 months. Radiologic failure rates at 6 and 9 months were significantly lower in the Biodentine group compared to the formocresol group. Compared to formocresol, Biodentine may be a superior medicament when used for pulpotomy in primary teeth. Adequately powered randomized controlled trials are needed to substantiate this evidence.

Evaluation of the Effect of Turmeric Gel and Turmeric Powder as Pulpotomy Medicaments in Primary Teeth

Evaluation of the Effect of Turmeric Gel and Turmeric Powder as Pulpotomy Medicaments in Primary Teeth

Histopathological Pulp Response to Platelet-Rich Plasma Pulpotomy in Primary teeth

Background: To overcome the disadvantages of various synthetic-based biomaterials used in pulp therapy, the researchers are directed towards innovation of novel materials that are biologically compatible. Platelet-rich plasma (PRP) is considered one of the novel biologically-based autologous substitutes. Purpose: To evaluate histopathologically the pulp response to the platelet-rich plasma as a pulpotomy medicament in primary teeth. Materials and methods: A total of 30 healthy lower first primary molars and canines that indicated for serial extraction were selected for this experiment. PRP and formocresol pulpotomies were performed (12 teeth/each group), where the other 6 teeth were used as a control. Four teeth from each experimental group and one control were extracted at post-treatment intervals; 14 days, one and three months. The samples were prepared and the tissues’ sections were stained with Hematoxylin & Eosin for histopathological evaluation. Using ordinary light microscope, all sections were histopathologically analyzed blindly in terms of soft tissues organization, degree of inflammatory reaction, hyperemic changes, pulp necrosis and dentin bridge formation. Statistical analysis: All data were analyzed with the Mann-Whitney U-test and the probability level of significance was accepted at p < 0.05. Results: The overall histopathological results of pulp response to PRP were statistically significant in terms of soft tissue organization, degrees of inflammation, hyperemia, and pulp necrosis than formocresol (p < 0.05). Conclusion: Histopathologically, it was concluded that PRP had induced significantly a successful healing biologic response than synthetic formacresol; serving as a potent autogenous pulpotomy medicament alternative to formocresol.

Pulpotomy medicaments in primary teeth: A literature review of natural alternatives

Pulpotomy is a procedure which involves complete amputation of the coronal pulp, followed by employment of an appropriate medicament that will stimulate healing and preserve the vitality of the tooth. This is the choice of treatment for cariously exposed vital primary molars, with formocresol considered as golden standard. However, controversies surrounding this medicament have generated inquisitiveness to exploration for natural alternatives. This narrative review is to focus on the use of natural products as alternative pulpotomy agents to formocresol so as to guide the clinicians in choosing proper medicament.

Clinical and Radiological Evaluation of Turmeric Powder as a Pulpotomy Medicament in Primary Teeth: An in vivo Study.

Many plants with biological and antimicrobiological properties have been studied since there has been a relevant increase in the incidence of antibiotic overuse and misuse. In dentistry, phytomedicines have been used as anti-inflammatory, antibiotic, analgesic, and sedative agents. Turmeric is used extensively in foods for its flavor and color, as well as having a long tradition of use in the Chinese and Ayurvedic systems of medicine, particularly as an anti-inflammatory and for the treatment of flatulence, jaundice, menstrual difficulties, hematuria, hemorrhage, and colic. This article studies ahead with a new idea of using powdered turmeric as a material of pulpotomy procedure in primary teeth.How to cite this articlePurohit RN, Bhatt M, Purohit K, Acharya J, Kumar R, Garg R. Clinical and Radiological Evaluation of Turmeric Powder as a Pulpotomy Medicament in Primary Teeth: An in vivo Study. Int J Clin Pediatr Dent 2017;10(1):37-40.

Evaluation and comparison of mineral trioxide aggregate and biodentine in primary tooth pulpotomy: Clinical and radiographic study.

Pulpotomy is the common therapy for cariously exposed pulps in symptom-free primary molar teeth. For many years, researchers have searched for an ideal material that allows regeneration of the residual pulp. The purpose of this study was to evaluate the efficacy of mineral trioxide aggregate (MTA), Biodentine as a pulpotomy medicament in primary teeth, both clinically and radiographically. A total of 25 children (50 human primary molar teeth) aged between 5 and 9 years were selected in this randomized clinical study. The patients were randomly assigned to receive the pulpotomy medicaments in either [Group 1]: MTA or [Group 2]: Biodentine. All pulpotomized teeth were restored with stainless steel crowns and evaluated clinically and radiologically at 1, 3, 6 and 12 months. Statistical analysis using Mann-Whitney U test and Fisher's exact test, and chi-square test was performed to determine the significant differences between the groups. Clinical and radiological success rates were 96 and 80% in Group 1 and 96 and 60% in Group 2, respectively. There were no significant differences between the groups (P > 0.05). The radiographic success rates decreased in the controls, but there were no significant differences. Biodentine showed similar clinical and radiographic results as MTA in the 12-month evaluation and can be safely used as a pulpotomy medicament.

Clinical and radiographical evaluation of mineral trioxide aggregate, biodentine and propolis as pulpotomy medicaments in primary teeth.

ObjectivesThe purpose of this study was to evaluate the efficacy of mineral trioxide aggregate (MTA), Biodentine and Propolis as pulpotomy medicaments in primary dentition, both clinically and radiographically.Materials and MethodsA total of 75 healthy 3 to 10 yr old children each having at least one carious primary molar tooth were selected. Random assignment of the pulpotomy medicaments was done as follows: Group I, MTA; Group II, Biodentine; Group III, Propolis. All the pulpotomized teeth were evaluated at 3, 6, and 9 mon clinically and radiographically, based on the scoring criteria system.ResultsThe clinical success rates were found to be similar among the three groups at 3 and 6 mon where as a significant decrease in success rate was observed in Group III (84%) compared to both Group I (100%) and Group II (100%) at 9 mon. Radiographic success rates over a period of 9 mon in Groups I, II, and III were 92, 80, and 72%, respectively.ConclusionsTeeth treated with MTA and Biodentine showed more favorable clinical and radiographic success as compared to Propolis at 9 mon follow-up.

Success Rates of Ankaferd Blood Stopper and Ferric Sulfate as Pulpotomy Agents in Primary Molars.

Purpose. The purpose of this study was to evaluate clinical and radiographic findings of treatments using a new hemostatic agent (Ankaferd blood stopper (ABS)), as compared to ferric sulfate (FS), when used as a pulpotomy medicament in primary teeth. Materials and Methods. The primary molars (70) were selected from 35 children aged 4 to 6 years. The teeth were randomized into two groups for pulpotomy with the ABS (n = 35) and the FS (n = 35) agents. The patients were recalled for clinical and radiographic evaluation at 3-, 6-, 9-, and 12-month intervals. Results. At the 3- and 6-month clinical and radiographic evaluations, total success rates of 100% were observed in each group. In ABS and FS groups, the clinical success rates, however, reduced to 90.9% and 93.9% at the 9-month examination and 84,8% and 90.9% at the 12-month examination, respectively. Similarly, the teeth in the ABS and FS groups had radiographic success rates of 90.9% and 93.9% at 9 months and 84.8% and 87.8% at 12 moths, respectively. Conclusion. Although the findings indicated that ABS agents may be useful agents for pulpotomy medicament, further long-term and comprehensive histological investigations of ABS treatments are necessary.

Effectiveness of MTA pulpotomy in primary molars: A critical assessment of relevant studies

Medline. Studies that evaluated the efficacy of MTA as a pulpotomy medicament in primary teeth were included, abstracts, observational studies and case reports were excluded. Only English language studies were considered. Studies were assessed and graded by two reviewers using a weighted criteria based system and a qualitative summary of the evidence provided. Twenty-two studies were included, 17 studies compared MTA with formocresol, four studies compared MTA with calcium hydroxide, ferric sulphate, Portland cement, calcium-enriched mixture cement (CEM) and one study compared white MTA with grey MTA. Based on the assessment criteria employed, there was no evidence that MTA was better than present materials and techniques as a pulpotomy medicament.

Is there sufficient evidence to support the long‐term efficacy of mineral trioxide aggregate (MTA) for endodontic therapy in primary teeth?

Several papers have been published to illustrate the effectiveness of mineral trioxide aggregate (MTA) as a pulpotomy medicament. Most of these reports do not offer a critical assessment on the data quality. Therefore, this review evaluated whether the currently available evidence is of an appropriate quality to support the long-term effectiveness of MTA as a pulpotomy medicament in primary molars using a standardized assessment criterion. A comprehensive literature search of human clinical outcome studies, which employed MTA as a pulpotomy medicament in primary teeth, was conducted using the MEDLINE database. Two independent observers rated these articles using the standardized assessment criteria. Furthermore, based on the initial sample mentioned in the individual studies and the sample included for the final analysis, the drop-out rates were calculated. Twenty-two studies were included for quality assessment with an excellent interobserver agreement. None of the 22 studies obtained grade A, four studies attained grade B1, five were graded B2 and 13 received grade C. Based on the assessment criteria employed, there was no evidence that MTA was better than present materials and techniques as a pulpotomy medicament. Furthermore, given the low quality of data, it is highly desirable to establish standard requisites for conducting and reporting on pulp therapy studies in primary teeth so as to benefit both researchers and clinicians to produce high-quality studies that are comparable and to prevent the misuse of clinical material and resources.