Pulp Capping Materials Research Articles

Marginal adaptation, physicochemical and rheological properties of treated dentin matrix hydrogel as a novel injectable pulp capping material for dentin regeneration

BackgroundTreated dentin matrix hydrogel (TDMH) has been introduced as a novel injectable direct pulp capping material. In this regard, this study aimed to evaluate its marginal adaptation, physicochemical and rheological properties for the development of clinically feasible TDMH.MethodsTDMH was applied to the pulp floor of prepared Class I cavities (n = 5), marginal adaptation was assessed by SEM at 1000 X magnification to detect gap between dentin and filling material. Five syringes were filled with TDMH and placed between the compression plates of a universal testing machine to evaluate injectability and gelation time was also evaluated by test vial inverting method. The microstructures of lyophilized TDMH were observed by SEM. Moreover, TDMH discs (n = 5) were prepared and the water uptake (%) was determined based on the equilibrium swelling theory state of hydrogels. Its solubility was measured after one week by the ISO standard method. Rheological behaviours of TDMH (n = 5) were analysed with a rotational rheometer by computing their complex shear modulus G* and their associated storage modulus (G′) and loss modulus (G′’). Statistical analysis was performed using F test (ANOVA) with repeated measures and Post Hoc Test (p = 0.05).ResultsTDMH presented an overall 92.20 ± 2.95% of continuous margins. It exhibited gelation during the first minute, and injectability mean was 66 ± 0.36%. TDMH showed a highly porous structure, and the pores were interconnected with an average diameter about 5.09 ± 3.17 μm. Swelling equilibrium gradually reached at 6 days up to 377%. The prepared hydrogels and maintained their shape after absorbing over three times their original weight of water. TDMH fulfilled the requirements of ISO 6876, demonstrating a weight loss of 1.98 ± 0.09% and linear viscoelastic behaviour with G` 479.2 ± 12.7 and G`` 230.8 ± 13.8.ConclusionsTDMH provided good marginal adaptation, appropriate physicochemical and viscoelastic properties support its use as a novel direct pulp capping material in future clinical applications.

Regenerative potential of a novel aloe vera modified tricalcium silicate cement as a pulp capping material: An animal study.

This study compared the histologic response of a pulp capping material Matreva MTA modified with different concentrations of aloe vera (AV) solutions to Biodentine cement. Ninety dogs' teeth were included and categorized according to the capping material into five groups (18 teeth each); Group I (Biodentine), group II (Matreva MTA), group III (Matreva MTA 10% AV), group IV (Matreva MTA 20% AV) and group V (Matreva MTA 30% AV). The histopathological findings were recorded at 2, 4, and 8 weeks. Matreva MTA and Biodentine groups showed the highest inflammatory cell count compared to the AV-modified Matreva MTA groups at 2- and 4-week intervals (p>0.05). Moreover, the AV-modified Matreva MTA and Biodentine groups showed higher dentin bridge thickness compared to unmodified Matreva MTA at different follow-up periods (p<0.05). AV can significantly enhance the in vivo bioactivity of Matreva MTA, inducing mild inflammation and good dentine bridge formation comparable to Biodentine.

Cone beam computed tomographic assessment of radiographic changes after indirect pulp capping using diode lasers and silver diamine fluoride in permanent molars with deep carious lesions

Aim: To compare the preservation of pulp vitality by indirect pulp capping using Diode laser and Silver Diamine Flouride in management of deep carious lesions. Methods: Thirty patients with an age range of 18-46 years were selected and randomly divided into 3 equal groups: Group 1 (Control group): indirect pulp capping was performed using Biodentine, Group 2: Diode laser with an output power of 0.5 watt was applied before Biodentine placement, and Group 3: Application of Silver Diamine Flouride followed by Biodentine. Pre-operative clinical assessment and radiographs were performed before intervention and then the patients received their treatment and final restorations. Follow-up with clinical assessments was performed after 3 and 6 months. Cone beam computed tomography was performed at the day of intervention and after 6 months. Clinical and Radiographic data were collected, tabulated and statistically analyzed to compare between the success rates of indirect pulp capping using diode laser, Silver Diamine Flouride and Biodentine in management of deep carious lesions. Results: The results of clinical assessment for all groups have shown success rate of 100%. The remaining dentin thickness was significantly increased in all study groups after application of intervention. Also, the remaining dentin density showed significant increase in all groups, where Diode laser application with an output power of 0.5 watt group was significantly higher than the control group, with no significant difference between other groups. Conclusions: Within the limitations of the current study, the following can be concluded: 1. Using Biodentine in indirect pulp capping is the treatment of choice in management of deep carious lesions. 2. Silver Diamine Flouride can be used as an alternative indirect pulp capping material. 3. Diode laser can show promising results in terms of Cavity Disinfection &amp; can have better biomodulating outcomes on the pulpal tissue healing and repair.

Evaluation of Indirect Pulp Capping Using MTA, Light-cured Calcium Silicate, and Propolis in Primary Teeth: A Clinical and Radiographic Study Using VistaScan.

Clinical and radiographic evaluation of mineral trioxide aggregate (MTA), TheraCal LC, and propolis when used as an indirect pulp capping agent in primary teeth over a period of 6 months. A total of 42 primary molar teeth from children aged 4-10 years were chosen for the study. The teeth were divided equally into three groups (group I: MTA, group II: light cured calcium silicate, and group III: propolis). The teeth were followed up clinically and radiographically at 3 and 6 months. The teeth that showed successful treatment outcomes clinically and radiographically were evaluated for the amount of dentin bridge formed at the end of 3 and 6 months, which was measured using CorelDRAW software. The data obtained was analyzed statistically using Statistical Package for the Social Sciences (SPSS) version 21. The mean change in dentin thickness from baseline to 3 months in group II was found to be the highest, followed by groups I and III. The mean change in dentin thickness from 3 months to 6 months was highest in group I, followed by groups III and II. The mean change in dentin thickness from baseline to 6 months in group II was found to be significantly higher than that of group I, followed by group III. Clinically and radiographically, all three materials showed favorable outcomes when used as an indirect pulp capping material with significant reparative dentin formation. The highest amount of dentin deposition was recorded with light-cured calcium silicate, followed by MTA and propolis, respectively. Saikia D, Yadav G, Saha S, et al. Evaluation of Indirect Pulp Capping Using MTA, Light-cured Calcium Silicate, and Propolis in Primary Teeth: A Clinical and Radiographic Study Using VistaScan. Int J Clin Pediatr Dent 2023;16(5):686-691.

GelMA/TCP nanocomposite scaffold for vital pulp therapy

Pulp capping is a necessary procedure for preserving the vitality and health of the dental pulp, playing a crucial role in preventing the need for root canal treatment or tooth extraction. Here, we developed an electrospun gelatin methacryloyl (GelMA) fibrous scaffold incorporating beta-tricalcium phosphate (TCP) particles for pulp capping. A comprehensive morphological, physical-chemical, and mechanical characterization of the engineered fibrous scaffolds was performed. In vitro bioactivity, cell compatibility, and odontogenic differentiation potential of the scaffolds in dental pulp stem cells (DPSCs) were also evaluated. A pre-clinical in vivo model was used to determine the therapeutic role of the GelMA/TCP scaffolds in promoting hard tissue formation. Morphological, chemical, and thermal analyses confirmed effective TCP incorporation in the GelMA nanofibers. The GelMA+20%TCP nanofibrous scaffold exhibited bead-free morphology and suitable mechanical and degradation properties. In vitro, GelMA+20%TCP scaffolds supported apatite-like formation, improved cell spreading, and increased deposition of mineralization nodules. Gene expression analysis revealed upregulation of ALPL, RUNX2, COL1A1, and DMP1 in the presence of TCP-laden scaffolds. In vivo, analyses showed mild inflammatory reaction upon scaffolds’ contact while supporting mineralized tissue formation. Although the levels of Nestin and DMP1 proteins did not exceed those associated with the clinical reference treatment (i.e., mineral trioxide aggregate), the GelMA+20%TCP scaffold exhibited comparable levels, thus suggesting the emergence of differentiated odontoblast-like cells capable of dentin matrix secretion. Our innovative GelMA/TCP scaffold represents a simplified and efficient alternative to conventional pulp-capping biomaterials. Statement of significanceVital pulp therapy (VPT) aims to preserve dental pulp vitality and avoid root canal treatment. Biomaterials that bolster mineralized tissue regeneration with ease of use are still lacking. We successfully engineered gelatin methacryloyl (GelMA) electrospun scaffolds incorporated with beta-tricalcium phosphate (TCP) for VPT. Notably, electrospun GelMA-based scaffolds containing 20% (w/v) of TCP exhibited favorable mechanical properties and degradation, cytocompatibility, and mineralization potential indicated by apatite-like structures in vitro and mineralized tissue deposition in vivo, although not surpassing those associated with the standard of care. Collectively, our innovative GelMA/TCP scaffold represents a simplified alternative to conventional pulp capping materials such as MTA and Biodentine™ since it is a ready-to-use biomaterial, requires no setting time, and is therapeutically effective.

A successful case of maturogenesis by stepwise excavation using calcium-enriched mixture cement

This case report demonstrates the successful induction of apexogenesis in an extensively carious lower right first molar with immature roots through the use of stepwise excavation and calcium-enriched mixture (CEM) cement as an indirect pulp capping material. The patient, an 8-year-old boy, presented with pain and carious pulp exposure. The initial treatment involved removing soft dentin and applying CEM cement as an indirect pulp cap. The patient experienced pain relief after 24 h, and subsequent follow-up appointments showed complete healing and maturation of the tooth. The case highlights the potential of indirect pulp treatment with CEM cement and emphasizes the importance of regenerative biomaterials in promoting healing and dentin bridge formation. Further clinical work and research are recommended to explore the efficacy of this treatment approach.

Effects of direct pulp capping with recombinant human erythropoietin and/or mineral trioxide aggregate on inflamed rat dental pulp.

This study aimed to evaluate the dental pulp responses to recombinant human erythropoietin (rhEPO) and/or mineral trioxide aggregate (MTA) in pulp capping of inflamed dental pulp in vivo. In accordance with ARRIVE guidelines, pulp inflammation was induced by exposing the maxillary first molars (n = 64) of Wistar rats (n = 32) to the oral environment for two days. The exposed pulps were randomly assigned four groups based on the pulp capping material: rhEPO, MTA, MTA + rhEPO, or an inert membrane. An additional eight rats formed the healthy control group. After four weeks, the animals were euthanized, and histological, qRT-PCR, and spectrophotometric techniques were employed to analyze the left maxillary segments, right first maxillary molars, and blood samples, respectively. Statistical significance was set at p < 0.05 and < 0.001. Pulp capping with rhEPO, MTA, or MTA + rhEPO resulted in lower inflammation and higher mineralization scores compared to untreated control. MTA + rhEPO group exhibited significantly decreased expression of tumor necrosis factor-alpha, and interleukin 1-beta, while MTA group showed substantially reduced expression of interferon-gamma. Both rhEPO and MTA + rhEPO groups presented elevated dentin matrix protein 1 levels compared to untreated control. Furthermore, pulp capping with rhEPO and/or MTA led to increased transforming growth factor-beta 1 expression and reductions of pro-inflammatory/immunoregulatory cytokine ratios and prooxidative markers. Pulp capping with rhEPO also resulted in increase of systemic antioxidative stress markers. Capping with rhEPO or MTA + rhEPO resulted in a favorable effect that was similar or even superior to that of MTA.

Shear bond strength of calcium silicate-based cements to composite resin using a universal adhesive in different application modes: an in vitro study.

To assess the shear bond strength (SBS) of four calcium silicate-based cements (CSCs) to composite resin using a universal adhesive in self-etch (SE) and etch-and-rinse (ER) modes and to evaluate surface microstructure and chemical composition of CSCs after acid-etching. In total, 30 specimens of each cement, Biodentine (BD), mineral trioxide aggregate (MTA) Angelus (MTA-A), ProRoot MTA (MTA-P) and MTA Repair HP (MTA-HP), were prepared and assigned into 2 groups (n = 15) according to universal adhesive (Clearfil Universal Bond Quick) applied in SE and ER mode. After composite resin (Clearfil Majesty Esthetic) was applied, the SBS was measured. Scanning electron microscope-energy dispersive spectroscopy (SEM-EDS) analysis was used to evaluate the changes in surface structure and elemental composition. MTA-P demonstrated significantly higher SBS than all CSCs, except for MTA-HP in the SE mode. The ER mode exhibited significantly higher SBS compared to the SE mode for MTA-P and MTA-A. Acid-etching caused morphological differences and affected elemental distribution. MTA-P may be a more suitable pulp capping material due to its superior SBS compared to BD and MTA-A. The application of a universal adhesive in ER mode may be suggested to increase the SBS of MTA-P and MTA-A to composite resin.

A comparative study of the biological and histological response of eggshell nanoparticles, hesperidin, and calcium hydroxide as direct pulp capping materials: An in vivo study on rat molars

A comparative study of the biological and histological response of eggshell nanoparticles, hesperidin, and calcium hydroxide as direct pulp capping materials: An in vivo study on rat molars

Farklı adeziv sistemlerin kalsiyum silikat esaslı pulpa kaplama materyallerine makaslama bağlanma dayanımının değerlendirilmesi

Aim: This study aimed to evaluate the shear bond strength (SBS) values of different adhesive systems to calcium silicate and calcium hydroxide-based pulp capping materials.&#x0D; &#x0D; Methods: Cylinder-shaped cavities (2x5 mm) were prepared in the middle of 120 acrylic blocks. Three pulp capping materials (Biodentine, TheraCal LC, Kerr Life) were placed into the cavities. Single Bond 2 (SB2), Clearfil SE Bond (CSB), Clearfil Universal Bond (CUB), Tokuyama Self-cured Universal Bond (TUB) were applied for each pulp capping material (n=10). After composite resin cylinders were prepared, SBS tests were carried out. Data and failure modes were analyzed using two-way ANOVA, Tamhane’s T2 (p≤0.05), and stereomicroscope, respectively.&#x0D; &#x0D; Results: TheraCal LC showed the highest SBS values, and there was a statistically significant difference amongst pulp capping materials for all adhesives (p≤0.05). The lowest results were found in the Life+TUB (0.79±0.14), and the highest was TheraCal LC+CSB (8.55±1.73). In Biodentine, all adhesive systems showed lower results than TheraCal LC groups, whereas there was a statistically significant difference between SB2 and TUB compared to the Life.&#x0D; &#x0D; Conclusion: TheraCal LC, which has the highest bond strength value in different generation adhesive systems, can be preferred as a pulp capping agent for composite restorations.

EFFECT OF ROBUSTA COFFEE BEANS AND ARABICA EXTRACT GEL AS INFLAMATION PULP MATERIAL

Background: Reversible pulpitis is a mild to moderate inflammatory pulp condition often treated with pulp capping treatments. Current study states that calcium hydroxide (CaOH2) has drawbacks for a long-time use. One of the alternative pulp capping materials is Robusta and Arabica coffee bean extract gel which contains flavonoid compounds and chlorogenic acid which have immunomodulatory properties that play role in the pulp inflammatory process by increasing the count of lymphocyte. Objective: The goal of this study is to determine and analyse the effect of Robusta coffee bean and Arabica coffee bean extract gel 95% to the of lymphocyte cells count on the 3rd and 5th day of pulp inflammation compared to placebo gel. Materials and Methods: This research is a true experimental with a post-test only control group design. This study used three treatment groups; Robusta coffee bean extract gel 95%, Arabica coffee bean extract gel 95%, and control group placebo gel. Results: Two Way Anova test results obtained p&lt;0.05, showed significant difference. Data analysis was continued with the Post Hoc Bonferroni test which showed that there was a significant difference between the 95% Robusta coffee bean extract gel group and the 95% Arabica coffee bean extract gel group with p&lt;0.05. Conclusion: The administration of Robusta coffee bean extract gel with a concentration of 95% can increase the of lymphocyte cells count in pulp inflammation on the 3rd and 5th days more effectively than the 95% Arabica coffee bean extract gel. Keywords: Arabica Coffee, Direct Pulp Capping, Inflammation, Lymphocytes, Pulpitis, Robusta Coffee

Solubility of three different pulp capping materials: a comparative study

Solubility of three different pulp capping materials: a comparative study

Efficacy of Combination of Biodentine and Simvastatin as Pulp Capping Materials in Vital Pulpotomy of Primary Molars: Randomized Clinical Trial

Efficacy of Combination of Biodentine and Simvastatin as Pulp Capping Materials in Vital Pulpotomy of Primary Molars: Randomized Clinical Trial

Effectiveness of silver diamine fluoride in indirect pulp capping in primary molars: A systematic review and meta-analysis

IntroductionRecently, clinical trials have assessed the effectiveness of Silver Diamine Fluoride (SDF) as an indirect pulp capping material (IPC) in primary teeth. This systematic review aimed to assess the evidence presented in these trials. Data sourcesA comprehensive search identified relevant studies through five electronic databases (PubMed, Scopus, ClinicalTrials.gov, ScienceDirect, and Cochrane). Search strategies were designed using the PICO model to identify all studies that investigated SDF as an IPC compared to calcium hydroxide (CaOH) or mineral trioxide aggregate (MTA). Quality assessment and Grading of Recommendations Assessment, Development, and Evaluation (GRADE) were used to assess the level of evidence. Study selectionFour clinical trials were found to be suitable for inclusion in the qualitative synthesis and three studies were included in the quantitative analysis. Three studies compared SDF with CaOH and only one study compared SDF, CaOH, and MTA. Only one randomized controlled trial (RCT) had a low risk of bias, and the non-RCT study had a moderate risk of bias. The level of evidence based on the GRADE was low. Three out of four studies showed higher clinical and radiographic outcomes with SDF than with CaOH. One non-RCT study showed that SDF resulted in the least reparative dentin at the 6-months follow-up. The meta-analysis showed a non-significant difference between the SDF and CaOH groups (P = 0.36). ConclusionThere is little evidence showing a higher clinical and radiographic outcome of SDF compared to CaOH as an IPC material in primary molars. Clinical significanceThis systematic review updates pediatric dentists regarding the effectiveness of using SDF as indirect pulp caping in primary teeth.

Epigenetic therapeutics in dental pulp treatment: Hopes, challenges and concerns for the development of next-generation biomaterials.

This opinion-led review paper highlights the need for novel translational research in vital-pulp-treatment (VPT), but also discusses the challenges in translating evidence to clinics. Traditional dentistry is expensive, invasive and relies on an outmoded mechanical understanding of dental disease, rather than employing a biological perspective that harnesses cell activity and the regenerative-capacity. Recent research has focussed on developing minimally-invasive biologically-based 'fillings' that preserve the dental pulp; research that is shifting the paradigm from expensive high-technology dentistry, with high failure rates, to smart restorations targeted at biological processes. Current VPTs promote repair by recruiting odontoblast-like cells in a material-dependent process. Therefore, exciting opportunities exist for development of next-generation biomaterials targeted at regenerative processes in the dentin-pulp complex. This article analyses recent research using pharmacological-inhibitors to therapeutically-target histone-deacetylase (HDAC) enzymes in dental-pulp-cells (DPCs) that stimulate pro-regenerative effects with limited loss of viability. Consequently, HDAC-inhibitors have the potential to enhance biomaterial-driven tissue responses at low concentration by influencing the cellular processes with minimal side-effects, providing an opportunity to develop a topically-placed, inexpensive bio-inductive pulp-capping material. Despite positive results, clinical translation of these innovations requires enterprise to counteract regulatory obstacles, dental-industry priorities and to develop strong academic/industry partnerships. The aim of this opinion-led review paper is to discuss the potential role of therapeutically-targeting epigenetic modifications as part of a topical VPT strategy in the treatment of the damaged dental pulp, while considering the next steps, material considerations, challenges and future for the clinical development of epigenetic therapeutics or other 'smart' restorations in VPT.

Combination Calcium Hydroxide and Epigallocatechin-3-gallate in Dentistry: A Narrative Review

Background: Pulp capping and pulpotomy are treatments for exposed pulp due to injury. Calcium hydroxide is the gold standard material in pulp capping and pulpotomy because it stimulates reparative dentin formation in exposed pulp. Calcium hydroxide has the disadvantage of causing chronic inflammation, cell necrosis, the formation of tunnel defects, and weak antibacterial properties against certain bacteria. Epigallocatechin-3-gallate (EGCG) is the main catechin component of green tea and has potent anti-inflammatory and antibacterial properties against both gram-negative and positive bacteria. The addition of EGCG to calcium hydroxide has the potential to prevent chronic inflammation and improve the antibacterial properties of calcium hydroxide. Purpose: This review aims to explain the potential of the combination of calcium hydroxide and EGCG in dentistry. Review(s): EGCG has potent anti-inflammatory and antibacterial effects against Enterococcus faecalis. The addition of EGCG to calcium hydroxide has the potential to reduce the inflammatory effect and improve the antibacterial properties of calcium hydroxide. Conclusion: This review concludes that the combination of calcium hydroxide and EGCG has the potential to reduce the inflammatory effect and promote the antibacterial effect of calcium hydroxide. Further research is needed to prove the potential of the combination of calcium hydroxide and EGCG in dentistry as a material for pulp capping and pulpotomy.

Differences in the solubility of CaCO3 from blood clam shells and Ca(OH)2 as a candidate pulp capping material

Background: Calcium hydroxide (Ca(OH)2) is the gold standar in pulp capping treatment because the biocompatibility and capability to stimulate hard tissue formation and also antibacterial effect. However, this compound has the disadvantage of being easily soluble in saliva which will increase the risk of leakage in the cavity. Another alternative pulp capping material is calcium carbonate from blood clam shells. Blood clam shells contain 98% CaCO3, CaCO3 has low solubility and is difficult to dissolve in water due to the large ions on Ca2+ and CO32- so that the attractive force between these ions is very strong and finally H2O is not able to break down the CaCO3 compound to be dissolved. Purpose: Explained the differences in the solubility of calcium carbonate from blood clam shells and calcium hydroxide as candidates pulp capping materials. Methods: This research is a laboratory experimental study with a pretest-posttest control group design method. The samples consisted of 12 pieces of Ca(OH)2 and CaCO3 then divided into 2 groups and given treatment. Group 1 CaCO3 immersed in 1 day, group 2 Ca(OH)2 immersed in 1 day, group 3 CaCO3 immersed in 7 days, and group 4 Ca(OH)2 immersed in 7 days. Solubility is calculated according to the solubility formula. Data testing with Anova-Welch. Results: There was a significanly difference in the solubility rate between the CaCO3 dan Ca(OH)2 groups immersed for 1 day and 7 days on the Anova-Welch results (p&lt;0.05). Conclusion: The solubility of CaCO3 in blood clam shells is lower than the solubility in Ca(OH)2.)

Efectivenesse of three pulp capping materials on cellular response of pulp tissue

Background: Pulp capping is a treatment that utilizes medications to preserve pulp vitality. Ca(OH)2, mineral trioxide aggregate (MTA), and biodentine are presently the most common pulp capping medications. As pulp capping materials, Ca(OH)2 and MTA are known to have several weaknesses. Biodentine has been created in an effort to mitigate the drawbacks of Ca(OH)2 and MTA. Thus, the purpose of this study is to compare the efficacy of three pulp capping medications in reducing inflammation and accelerating pulp regeneration.&#x0D; Methods: Total 48 male Wistar rats, that were divided into 4 groups, namely 1st control group, 2nd MTA group, 3rd biodentine group, and 4th Ca(OH)2 group. Maxillary 1st molar teeth of rats were prepared using round bur no. 080 perpendicular to the tooth axis to a depth of 1mm, until a reddish color appeared on the pulp. Furthermore, pulp capping medicament was applied to the deepest points, and temporary fillings were made with Zn2(PO4)3. Decapitation was carried out on days 4 and 7 to count the number of neutrophil cells, macrophages, odontoblast-like cells, and fibroblasts. Data were analyzed using One-way ANOVA (p

Non-Destructive In Vitro Evaluation of an Internal Adaptation of Recent Pulp-Capping Materials in Permanent Teeth Using OCT and Micro-CT.

The objective of this study was to assess and compare the internal adaptation of various pulp-capping materials, namely TheraCal, Biodentine, and mineral trioxide aggregate (MTA), on the dentin of permanent teeth through the utilization of micro-computed tomography (MCT) and optical coherence tomography (OCT). Thirty permanent molars were divided into three groups using a random process: group A (TheraCal), group B (Biodentine), and group C (MTA, which served as the control group). On the buccal surface of each tooth, a class V cavity of a standardized cylindrical shape was prepared. Subsequently, the respective pulp-capping material was applied to the cavity based on the assigned group, followed by restoration with composite resin. Based on the MCT results, it was observed that group A had a considerably larger gap volume in comparison to groups B and C (p < 0.001). There was no significant difference in gap volume between groups B and C. Regarding the OCT findings, group A displayed a substantially higher level of light reflection than groups B and C (p < 0.001). Group C exhibited a significantly lower level of light reflection in comparison to group B (p < 0.001). Biodentine and MTA revealed similar outcomes in terms of how well they adhered to the dentinal surface in permanent teeth. Both materials exhibited superior performance in comparison to TheraCal. The utilization of OCT in clinical practice could be advantageous as it enables dentists to monitor and evaluate restorations during post-treatment follow-up. It is imperative to intensify efforts aimed at making OCT equipment more accessible and applicable, overcoming its current limitations, and allowing for its widespread utilization in clinical practice.

Approaches to vital pulp therapies.

Tooth decay, which leads to pulpal inflammation due to the pulp's response to bacterial components and byproducts is the most common infectious disease. The main goals of clinical management are to eliminate sources of infection, to facilitate healing by regulating inflammation indental tissue, and to replace lost tissues. A variety of novel approaches from tissue engineering based on stem cells, bioactive molecules, and extracellular matrix-like scaffold structures to therapeutic applications, or a combination of all these are present in the literature. Shortcomings of existing conventional materials for pulp capping and the novel approches aiming to preserve pulp vitality highligted the need for developing new targeted dental materials. This review looks at the novel approches for vital pulp treatments after briefly addresing the conventional vital pulp treatment as well as the regenerative and self defense capabilities of the pulp. A narrative review focusing on the current and future approaches for pulp preservation was performed after surveying the relevant papers on vital pulp therapies including pulp capping, pulpotomy, and potential approaches for facilitating dentin-pulp complex regeneration in PubMed, Medline, and Scopus databases.