Pulmonary Tumors In Mice Research Articles

Pulmonary Tumours and Group VII in the House-Mouse

CERTAIN aspects of the experiments reported in Dr. J. A. H. Tatchell's recent communication1 are likely to result in misunderstanding of the genetic nature of the inheritance of susceptibility to pulmonary tumours in mice. Heston2 has established that the inheritance of susceptibility to pulmonary tumours in mice is multifactorial in nature and therefore the further investigation of this problem requires an approach designed to take this into account. The experiment reported by Dr. Tatchell does not appear to do so.

Inheritance of susceptibility to induced pulmonary tumours in mice.

Inheritance of susceptibility to induced pulmonary tumours in mice.

Combined action of cigarette tar and beta radiation on mice.

CancerVolume 14, Issue 2 p. 344-352 ArticleFree Access Combined action of cigarette tar and beta radiation on mice E. V. Cowdry PH.D., E. V. Cowdry PH.D. Wernse Cancer Research Laboratory, Washington University School of Medicine, St. Louis, Mo.Search for more papers by this authorA. Croninger M.A., A. Croninger M.A. Wernse Cancer Research Laboratory, Washington University School of Medicine, St. Louis, Mo.Search for more papers by this authorS. Solaric M.D., S. Solaric M.D. Wernse Cancer Research Laboratory, Washington University School of Medicine, St. Louis, Mo.Search for more papers by this authorV. Suntzeff M.D., V. Suntzeff M.D. Wernse Cancer Research Laboratory, Washington University School of Medicine, St. Louis, Mo.Search for more papers by this author E. V. Cowdry PH.D., E. V. Cowdry PH.D. Wernse Cancer Research Laboratory, Washington University School of Medicine, St. Louis, Mo.Search for more papers by this authorA. Croninger M.A., A. Croninger M.A. Wernse Cancer Research Laboratory, Washington University School of Medicine, St. Louis, Mo.Search for more papers by this authorS. Solaric M.D., S. Solaric M.D. Wernse Cancer Research Laboratory, Washington University School of Medicine, St. Louis, Mo.Search for more papers by this authorV. Suntzeff M.D., V. Suntzeff M.D. Wernse Cancer Research Laboratory, Washington University School of Medicine, St. Louis, Mo.Search for more papers by this author First published: March/April 1961 https://doi.org/10.1002/1097-0142(196103/04)14:2<344::AID-CNCR2820140214>3.0.CO;2-MCitations: 4AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL References 1 Bali, T., and Furth, J.: Morphological and biological characteristics of x-ray induced transplantable ovarian tumors. Cancer Res. 9: 449– 472, 1949. 2 Dunn, T. B.: Morphology of mammary tumors in mice. In F. Homburger, Ed.: The Physiopathology of Cancer, by 32 Authors, 2d ed. New York, N. Y. Paul B. Hoeber, Inc. 1959; pp. 38– 84. 3 Furth, J., and Baldini, M.: Physiopathology of leukemia. In F. Homburger, Ed.: The Physiopathology of Cancer, by 32 Authors, 2d ed. New York, N. Y. Paul B. Hoeber, Inc. 1959; pp. 364– 468. 4 Furth, J., and Boon, M. C.: Enhancement of leukemogenic action of methylcholanthrene by pre-irradiation with x-rays. Science 98: 138– 139, 1943. 5 Horn, H. A.; Congdon, C. C.; Eschenbrenner, A. B.; Andervont, H. B., and Stewart, H. L.: Pulmonary adenomatosis in mice. J. Nat. Cancer Inst. 12: 1297– 1303, 1951–1952. 6 Kaplan, H. S.: Observations on radiation-induced lymphoid tumors of mice. Cancer Res. 7: 141– 147, 1947. 7 Kaplan, H. S.: Influence of thymectomy, splenectomy, and gonadectomy on incidence of radiation-induced lymphoid tumors in strain C57 black mice. J. Nat. Cancer Inst. 11: 83– 90, 1950–1951. 8 Kaplan, H. S.: On etiology and pathogenesis of leukemias; review. Cancer Res. 14: 535– 548, 1954. 9 Kirschbaum, A.; Shapiro, J. R., and Mixer, H. W.: Synergistic action of estrogenic hormone and x-rays in inducing thymic lymphosarcoma of mice. Proc. Soc. Exper. Biol. & Med. 72: 632– 634, 1949. 10 Kirschbaum, A.; Shapiro, J. R., and Mixer, H. W.: Synergistic action of leukemogenic agents. Cancer Res. 13: 262– 268, 1953. 11 Mixer, H. W., and Kirschbaum, A.: Additive effects of x-rays and methylcholanthrene in inducing mouse leukemia. Radiology 50: 476– 480, 1948. 12 Raper, J. R.: Beta rays; biologic effects. In O. Glasser, Ed.-in-Chief: Medical Physics, vol. 2. Chicago, Ill. The Year Book Publishers, Inc. 1950; pp. 66– 71. 13 Raper, J. R.; Henshaw, P. S., and Snider, R. S.: Effects of periodic total-surface beta irradiation. In R. E. Zirkle, Ed.: Effects of External Beta Radiation, National Nuclear Energy Division Series IV, vol. 22 E. New York. N. Y. McGraw-Hill Book Company, Inc. 1951; pp. 212– 226. 14 Stewart, H. L.: Pulmonary tumors in mice. In F. Homburger, Ed.: The Physiopathology of Cancer, by 32 Authors, 2d ed. New York, N. Y. Paul B. Hoeber, Inc. 1959; pp. 18– 37. 15 Suntzeff, V.; Cowdry, E. V., and Croninger, A.: Preliminary report of investigation of possible synergistic effect between beta radiation and cigarette tar. Proc. Am. A. Cancer Res. 3: 68, 1959. 16 Wynder, E. L.; Graham, E. A., and Croninger, A. B.: Experimental production of carcinoma with cigarette tar. Cancer Res. 13: 855– 864, 1953. Citing Literature Volume14, Issue2March/April 1961Pages 344-352 ReferencesRelatedInformation

Induction of pulmonary tumors in mice by subcutaneous injection of 4-nitroquinolone N-oxide.

Induction of pulmonary tumors in mice by subcutaneous injection of 4-nitroquinolone N-oxide.

Influence of Altered Atmospheric Oxygen on Urethan-Induced Pulmonary Tumors in Mice&lt;xref ref-type="fn" rid="FN1"&gt;2&lt;/xref&gt;

Influence of Altered Atmospheric Oxygen on Urethan-Induced Pulmonary Tumors in Mice&lt;xref ref-type="fn" rid="FN1"&gt;2&lt;/xref&gt;

The role and action of environmental agents in the pathogenesis of hung cancer. I. Air pollutants.

The role and action of environmental agents in the pathogenesis of hung cancer. I. Air pollutants.

Growth of Pulmonary Tumors in Mice of Strains A and C3H

Growth of Pulmonary Tumors in Mice of Strains A and C3H

Increase in induced pulmonary tumors in mice associated with exposure to high concentration of oxygen.

SummaryStrain A mice injected at 2 months of age with dibenz [a, h] anthracene and immediately thereafter exposed for 48 hours to approximately 100% oxygen had when killed and examined 4 months later a significantly greater average number of pulmonary tumors than did the controls injected with dibenz [a, h] anthracene and kept in air.

Development of Pulmonary Tumors in Mice Segregated With Respect to The Three Genes : Dominant Spotting, Caracul, and Fused

Development of Pulmonary Tumors in Mice Segregated With Respect to The Three Genes : Dominant Spotting, Caracul, and Fused

A Quantitative Interpretation of the Distribution of Induced Pulmonary Tumors in Mice&lt;xref ref-type="fn" rid="fn1"&gt;2&lt;/xref&gt;

A Quantitative Interpretation of the Distribution of Induced Pulmonary Tumors in Mice Milton J. Polissar, Milton J. Polissar Search for other works by this author on: Oxford Academic PubMed Google Scholar Michael B. Shimkin Michael B. Shimkin Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 15, Issue 2, October 1954, Pages 377–403, https://doi.org/10.1093/jnci/15.2.377 Published: 01 October 1954 Article history Received: 03 May 1954 Published: 01 October 1954

Occurrence of Pulmonary Tumors in Mice of Strains A, BL, and SWR and Their F&lt;sub&gt;1&lt;/sub&gt; Hybrids Following Intravenous Injection of 1,2,5,6-Dibenzanthracene&lt;xref ref-type="fn" rid="fn1"&gt;2&lt;/xref&gt;

Occurrence of Pulmonary Tumors in Mice of Strains A, BL, and SWR and Their F&lt;sub&gt;1&lt;/sub&gt; Hybrids Following Intravenous Injection of 1,2,5,6-Dibenzanthracene&lt;xref ref-type="fn" rid="fn1"&gt;2&lt;/xref&gt;

Induced Pulmonary Tumors in Mice. IV. Analysis of Dose Response Data with Methylcholanthrene

Induced Pulmonary Tumors in Mice. IV. Analysis of Dose Response Data with Methylcholanthrene

Relationship between the Hairless Gene and Susceptibility to Induced Pulmonary Tumors in Mice

Relationship between the Hairless Gene and Susceptibility to Induced Pulmonary Tumors in Mice Get access W. E. Heston, W. E. Heston principal geneticist National Cancer Institute, National Institutes of Health, Public Health Service, Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar Margaret K. Deringer Margaret K. Deringer biologist National Cancer Institute, National Institutes of Health, Public Health Service, Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 10, Issue 1, August 1949, Pages 119–124, https://doi.org/10.1093/jnci/10.1.119 Published: 01 August 1949 Article history Received: 04 April 1949 Published: 01 August 1949

Some Unusual Findings on the Carcinogenic Action of Urethane in Mice

THE induction of pulmonary tumours in mice following ethyl carbamate (urethane) treatment was originally described by Nettleship, Henshaw and Meyer1 and has been confirmed by numerous workers. Similar effects of urethane in the rat have been noted by Jaffe2. The lung tumours described have been adenomata, usually multiple, appearing by three months after oral or injected, single or multiple doses of urethane (solutions of 5 or 10 per cent). In histological appearance the tumours are the same as spontaneous lung tumours arising in strain A mice and are of relatively low-grade malignancy. Successful transplantation has not been reported. The findings reported below were obtained on Rockland ‘Swiss' albino mice in experiments investigating the carcinogenic action of urethane. The preliminary results obtained are so unusual that they are presented in a very incomplete form, so that the effects may be looked for by other investigators and the apparent action considered by those using urethane for clinical therapy. More detailed results will be presented shortly from a repetition of these and other experiments now in progress.

Induction of Pulmonary Tumors in Mice With Ethyl Carbamate (Urethane)

Induction of Pulmonary Tumors in Mice With Ethyl Carbamate (Urethane)

Inheritance of Susceptibility to Spontaneous Pulmonary Tumors in Mice

Inheritance of Susceptibility to Spontaneous Pulmonary Tumors in Mice

Genetic Analysis of Susceptibility to Induced Pulmonary Tumors in Mice

Genetic Analysis of Susceptibility to Induced Pulmonary Tumors in Mice

Induced Pulmonary Tumors in Mice. III. The Role of Chronic Irritation in the Production of Pulmonary Tumors in Strain a Mice

Induced Pulmonary Tumors in Mice. III. The Role of Chronic Irritation in the Production of Pulmonary Tumors in Strain a Mice

Pulmonary Tumors in Mice

Pulmonary Tumors in Mice

Pulmonary Tumors in Mice: V. Further Studies on the Influence of Heredity upon Spontaneous and Induced Lung Tumors

Pulmonary Tumors in Mice: V. Further Studies on the Influence of Heredity upon Spontaneous and Induced Lung Tumors