Changes in the feeding pattern of the population have recently led to a greater occurrence of<br />cardiovascular risk factors that contribute to a high rate of morbidity and mortality worldwide. The<br />presence of beneficial bioactive compounds in fruits and processed sub-products have proven to have<br />a negative association with risk factors, such as blood pressure reduction, plasmatic lipoproteins control<br />and increased resistance of LDL-c to oxidation, in addition to glycemic control and antioxidant effects.<br />The aim of this review is to show that several studies have demonstrated many different chemical<br />compounds in seeds, leaves and fruit peels, including their metabolic and physiologic effects on the risk<br />factors of cardiovascular diseases. We reviewed the relevant literature by searching English-language<br />publications in Pubmed, Google Scholar, Scielo and Lilacs, and references from relevant articles<br />published since 2010, especially in the last five years. Eighty-seven relevant articles were included.