Publication In Peer-reviewed Journals Research Articles

Effect of transcranial direct current stimulation combined with transcutaneous auricular vagus nerve stimulation on poststroke cognitive impairment: a study protocol for a randomised controlled trial

IntroductionPoststroke cognitive impairment is a common complication in stroke survivors, seriously affecting their quality of life. Therefore, it is crucial to improve cognitive function of patients who had a stroke....

Collaborative design of a health research training programme for nurses and midwives in Tshwane district, South Africa: a study protocol

IntroductionNurses are essential for implementing evidence-based practices to improve patient outcomes. Unfortunately, nurses lack knowledge about research and do not always understand research terminology. This study aims to develop an...

Defining predictors of responsiveness to advanced therapies in Crohn’s disease and ulcerative colitis: protocol for the IBD-RESPONSE and nested CD-metaRESPONSE prospective, multicentre, observational cohort study in precision medicine

IntroductionCharacterised by chronic inflammation of the gastrointestinal tract, inflammatory bowel disease (IBD) symptoms including diarrhoea, abdominal pain and fatigue can significantly impact patient’s quality of life. Therapeutic developments in the...

Community-based interventions targeting multiple forms of malnutrition among adolescents in low-income and middle-income countries: protocol for a scoping review

BackgroundAdolescent malnutrition is a significant public health challenge in low-income and middle-income countries (LMICs), with long-term consequences for health and development. Community-based interventions have the potential to address multiple forms...

What Is Hot and New in Basic and Translational Science in Liver Transplantation in 2023? Report of the Basic and Translational Research Committee of the International Liver Transplantation Society.

The 2023 Joint Annual Congress of the International Liver Transplantation Society, European Liver and Intestine Transplant Association, and Liver Intensive Care Group of Europe were held in Rotterdam, the Netherlands, from May 3 to 6, 2023. This year, all speakers were invited to attend the Congress in person for the first time since the COVID-19 pandemic. The congress was attended by 1159 registered delegates from 54 countries representing 5 continents, with the 10 countries comprising the bulk of the delegates. Of the 647 abstracts initially submitted, 542 were eventually presented at the meeting, coming from 38 countries (mainly North America, Europe, and Asia) and 85% of them (462 abstracts) came from only 10 countries. Fifty-three (9.8%) abstracts, originated from 17 countries, were submitted under the Basic/Translational Scientific Research category, a similar percentage as in 2022. Abstracts presented at the meeting were classified as (1) ischemia and reperfusion injury, (2) machine perfusion, (3) bioengineering and liver regeneration, (4) transplant oncology, (5) novel biomarkers in liver transplantation, (6) liver immunology (rejection and tolerance), and (7) artificial intelligence and machine learning. Finally, we evaluated the number of abstracts commented in the Basic and Translational Research Committee-International Liver Transplantation Society annual reports over the past 5 y that resulted in publications in peer-reviewed journals to measure their scientific impact in the field of liver transplantation.

The Interplay between Gut Microbiota and Cognitive Functioning in the Healthy Aging Population: A Systematic Review.

The gut microbiota in healthy older individuals typically show a decrease in beneficial bacteria like Bifidobacterium and Lactobacillus, alongside an increase in pro-inflammatory microbes such as Enterobacteriaceae and Clostridia. These changes contrast with younger and middle-aged individuals and appear to correlate with cognitive status. Although there is extensive research on gut microbiota and cognitive functions in cognitively impaired elderly individuals, its impact on cognitively healthy elderly populations has not been extensively studied. A comprehensive literature search was conducted across PubMed, EBSCO, Web of Science, and Scopus databases to identify studies exploring the relationship between gut microbiota composition and cognitive functioning in healthy older adults. During the literature screening process, each record was initially assessed by its title, abstract, and keywords to exclude articles that did not align with the scope of this review. Three authors independently screened and retrieved the records. The inclusion criteria included: (1) publication in peer-reviewed journals; (2) studies involving neurologically, cognitively, and medically healthy populations; (3) participants identified as older adults, defined for this review as individuals aged 45 years and older due to the limited number of records; (4) analysis of gut microbiota; and (5) assessment of cognitive function. Subsequently, full texts were analyzed to determine eligibility. The exclusion criteria encompassed: (1) incorrect publication type; (2) inappropriate sample population; (3) unsuitable study design; (4) absence of one or more inclusion criteria; and (5) studies based on animal research. A risk of bias assessment was performed for each included study using the Joanna Briggs Institute (JBI) checklist, ensuring all selected studies met established quality standards. A total of 6 eligible research articles from a possible 1752 published until March 2024 were identified and included. We categorized the included studies into two groups based on their focus: the taxonomic composition of gut microbiota and the alpha diversity, which is the variety of organisms within a sample. Additionally, two methods were identified for assessing cognition: neuropsychological tests and physiological measurements, notably electroencephalography (EEG). The studies show varying results regarding the abundance of specific bacterial taxa and their cognitive associations. Notably, the relationship between certain bacteria and cognition may vary when analyzed at different taxonomic levels, such as phylum versus family. Changes in gut microbiota composition in the elderly, even without a cognitive impairment diagnosis, could potentially serve as early biological markers for Alzheimer's disease or other dementias before mild cognitive impairment appears.

DNP-Authored Articles in Peer-Reviewed Journals 2011-2021.

With an increasing number of doctor of nursing practice (DNP) graduates, the volume of peer-reviewed journal publications among DNP-prepared nurses is rising. The primary aim of this study was to quantify, analyze, and categorize DNP-authored peer-reviewed journal publications. A descriptive research design was used to analyze DNP-authored peer-reviewed journal publications in the WorldCat, EBSCO Discovery Service, and PubMed databases from 2011 through 2021. The 3839 journal publications included at least one DNP-prepared nurse author. There were 2495 (65%) publications with a DNP first author, 921 (24%) with a DNP solo author, and 2918 (76%) included publication collaboration. The majority of publications were practice- (40%), nursing- (17%), and education-focused (15%). Science translation in evidence-based practice and quality improvement publications accounted for 24%. This study demonstrates the proliferation of DNP-authored peer-reviewed journal publications, which may indicate an increase in the number of nursing care quality initiatives occurring in the clinical setting.

Epicardial left atrial appendage clipping versus direct oral anticoagulant to reduce stroke risk in non-paroxysmal atrial fibrillation (LAA-CLIP): rationale, design and study protocol for a multicentre randomised controlled trial

IntroductionThe prevalence of atrial fibrillation (AF) is increasing globally, and stroke prevention is the key to reduce the morbidity and mortality related to AF. Currently, direct oral anticoagulants (DOACs) are...

Effects of haemodiafiltration or haemofiltration compared with haemodialysis on prognosis in patients with end-stage renal disease: protocol an updated systematic review and meta-analysis of randomised trials with trial sequential analysis

IntroductionHaemodialysis is the most common treatment option for patients with life-sustaining end-stage kidney disease (ESKD). In recent years, haemodiafiltration or haemofiltration has been widely used in patients with ESKD, and...

Approaches for the treatment of perforated peptic ulcers: a network meta-analysis of randomised controlled trials – study protocol

IntroductionPerforated peptic ulcers are a life-threatening complication associated with high morbidity and mortality. Several treatment approaches are available. The aim of this network meta-analysis (NMA) is to compare surgical and...

REKOVER study protocol: a pRospective patient treatment rEgistry of tramadol and dexKetoprofen trometamol oral fixed-dose combination (SKUDEXA) in mOderate to seVere acutE pain in Real-world setting in Asia

IntroductionSatisfactory management of acute pain remains a major medical challenge despite the availability of multiple therapeutic options including the fixed-dose combination (FDC) drugs. Tramadol and dexketoprofen trometamol (TRAM/DKP) 75/25 mg...

Patterns of dissertation dissemination: publication-based outcomes of doctoral theses in the social sciences

AbstractDissemination of knowledge through the publication of findings is a cornerstone of the academic research system. Doctoral dissertations document the findings made by early-stage researchers during their doctoral studies. However, prior research suggests that dissertations may not be effective in disseminating these findings to the broader community of researchers. We study how knowledge documented in doctoral dissertations is disseminated. Specifically, we investigate which dissertation characteristics and institutional factors are related to the number of journal publications based on these dissertations and the number of citations that these publications receive. Our analysis uses a random sample of doctoral dissertations from German universities in economics, political science, and sociology. We find that “cumulative” dissertations—dissertations consisting of a number of separate articles—are turned into three times more publications which receive three times more citations than monographic dissertations. We also find explorative evidence that dissertations written in English and empirical dissertations have higher publication-based outcomes. We conclude that a policy allowing doctoral candidates to write their dissertations in a cumulative format provides them with an opportunity to share the results of their research through publications in peer-reviewed journals.

Affect of Features of a Microorganism Strain on a Scope of Exclusive Rights

Introduction. A launch of larger number of pharmaceutical preparations based on recombinant products and biotechnologies leads to determine a strategy for protection of exclusive rights for subjects implemented into manufacturing process, including strains of microorganism-producers.Aim. To define a possibility and a protection scope of microorganism strain as intellectual property subjects at a step of research, development and launch of pharmaceutical preparations, including biotechnological products.Materials and methods. The materials of the study were available publications in peer-reviewed journals on thematic queries based on keywords of the selected topic, official websites, regulatory legal acts, regulating the procedure for patenting subjects in the Russian Federation and foreign countries.Results and discussion. A brief review of regulatory acts on registration of a strain as an intellectual property subject is presented. It was defined features of a microorganism strain for patenting and for establishing an infringement of patent rights in the territory of Russian and foreign countries. A possible scope of patent rights for strains is indicated.Conclusion. The problems raised upon protecting strains as intellectual property subjects as well as possibilities of strain registration as exclusive right subjects are defined.

Industrial Internet of Things (IIoT) and Other Industry 4.0 Technologies in Spare Parts Warehousing in the Oil and Gas Industry: A Systematic Literature Review

Background: Spare parts warehousing in the oil and gas industry is essential for offshore production. With the introduction of Industry 4.0 and its subsequent technological tools, new functions are enabled in industrial logistics activities. Efficiency, visibility, optimization, and productivity are often mentioned as benefits of successful Industry 4.0 technology implementation in logistics activities. In this paper, the implementation of Industry 4.0 technologies such as the Industrial Internet of Things (IIoT) in spare parts warehousing in the oil and gas industry is studied. Method: 133 peer-reviewed journal publications indexed in Scopus and Web of Science are analyzed in a systematic literature review. The review is structured as frequency and content analysis. Aim: As there is limited research on this specific topic, the aim is for this paper to be a theoretical foundation that assists the industry with future solutions. Results: The list of benefits of implementation gathered from the literature is comprehensive. However, the list of challenges is particularly pertinent to the oil and gas industry and indicates a strong inclination towards limited and controlled implementation of some technologies. The safety demands of the industry mean there are many limitations to implementation currently. Conclusions: This paper reflects on the results, identifies research gaps, and gives proposals for future research.

What might make nurses stay? A protocol for discrete choice experiments to understand NHS nurses’ preferences at early-career and late-career stages

IntroductionLike many countries, England has a national shortage of registered nurses. Employers strive to retain existing staff, to ease supply pressures. Disproportionate numbers of nurses leave the National Health Services...

Study protocol for FASTRAK: a randomised controlled trial evaluating the cost impact and effectiveness of FAST-MRI for HCC suRveillance in pAtients with high risK of liver cancer

IntroductionThe surveillance of hepatocellular carcinoma (HCC) using semi-annual liver ultrasound (US) is justified in patients with cirrhosis. In this context, US has a low sensitivity (<30%) for the detection of...

Protocol of a scoping review of outcome domains in dermatology

IntroductionCore outcome sets (COSs) are agreed outcomes (domains (subdomains) and instruments) that should be measured as a minimum in clinical trials or practice in certain diseases or clinical fields. Worldwide,...

Manchester Intermittent Diet in Gestational Diabetes Acceptability Study (MIDDAS-GDM): a two-arm randomised feasibility protocol trial of an intermittent low-energy diet (ILED) in women with gestational diabetes and obesity in Greater Manchester

IntroductionThe prevalence of gestational diabetes mellitus (GDM) is rising in the UK and is associated with maternal and neonatal complications. National Institute for Health and Care Excellence guidance advises first-line...

Breastfeeding assessment and management instruments: a scoping review protocol

IntroductionDifferent aspects are involved in the breastfeeding process that may vary according to the target population, postpartum phase and evaluation scenario. The identification of such instruments, their constructs and applicability...

Assessment of the role of gut health in childhood stunting in a multisite, longitudinal study in India, Indonesia and Senegal: a UKRI GCRF Action Against Stunting Hub protocol

IntroductionChildhood stunting has a complex aetiology, with poor gut health being an important contributor. This study will assess inter-relationships between maternal and infant gut health indices and infant linear growth....