Publication In September Research Articles

Walker’s Appeal... is the main manifesto of radical African-American abolitionism

This work is about one of the key episodes of African-American history and the history of American abolitionism associated with the publication in September 1829 in Boston of Walker’s Appeal, in Four Articles; Together with a Preamble, to the Coloured Citizens of the World. The appearance of this “revolutionary appeal” undoubtedly marked a new milestone in the development of the anti-slavery movement and the actual emergence of such a trend as radical African-American abolitionism. The reaction to the release of this document by the authorities of the Southern States can be called unprecedented in its scale and consequences. It found expression in the adoption of a number of repressive laws, which, in turn, marked the beginning of a period of prolonged reaction in the American South, which would end only after the end of the Civil War of 1861–1865. The significance of this event is difficult to overestimate. After almost two centuries, the figure of David Walker and his Appeal still arouse increased interest from Western researchers and not only. However, no serious works on this topic have been published in Russian historiography up to the present moment. This study aims to identify and examine the causes and circumstances of the writing of the Walker’s Appeal…, to analyze the main provisions of this document and the consequences caused by its dissemination. In addition, the author pays special attention to the review of the historiography of this issue. The source base is newspaper publications, letters and bills of the period under review, as well as the text of the Appeal. The methodological basis of the research consists of causal, historical-descriptive, historical-genetic, historical-typological, retrospective, and comparative-historical methods. The materialistic dialectic plays the main role, showing the development of the abolitionist movement in dynamics and the influence of related factors. The author concludes that Walker’s Appeal… became an expression of the most important trend in the development of American abolitionism at the end of the first third of the nineteenth century. The appearance of this document clearly demonstrated the radicalization of the African-American community itself and its willingness to join the struggle for the abolition of slavery and its rights.

O-174 The transition from fertility to maternity care services - a Royal College of Nursing publication

Abstract Study question Is there a need for guidance for nurses and midwives involved in the delivery of care for patients transitioning from fertility service to maternity services. Summary answer There is a potential knowledge gap that exists in the transition of care from fertility to maternity services. What is known already Once a patient becomes pregnant through fertility treatment in the UK, they are usually discharged out into NHS maternity care services via their general practitioner. This means that the maternity service staff are often unaware of the time it has taken to conceive, fertility treatments and procedures, fertility medications and emotional trauma that the patient has been through already and may not be aware of some of the complexities surrounding the fertility treatment journey. Study design, size, duration A project group of 14 key contributors was invited to be part of the publication that included fertility nurses, midwives, early pregnancy specialist nurses and patient representative members. An initial literature review took place and each person contributed from their specialist area. The project to produce the guidance took 9 months of planning, reviewing and meeting to discuss content with a final publication in September 2022. Participants/materials, setting, methods An initial literature review of the project subject did not highlight any existing research or publications in this area. A forum governance bid was submitted to produce a 45 page online resource aimed at fertility nursing staff, early pregnancy care staff and maternity services staff. The key project team contributed from their specialist areas and was reviewed by stakeholder groups. Main results and the role of chance Pregnancy following fertility treatment can be an exciting, challenging and anxious time for expectant parents. This projects aim was to primarily raise awareness of possible pathways of care for women and others (their partners/support networks) as they travel through fertility treatment and pregnancy, and how they can best be supported by the health care professionals they encounter along their journey. A 45 page online resource was produced and disseminated to fertility, early pregnancy and maternity staff via stakeholder groups and a webinar to launch the publication. Limitations, reasons for caution No limitations identified. The publication is available for all staff working in all three areas and provided guidance for all patient pathways including those from the LGBTQIA community. Wider implications of the findings No wider implications. Trial registration number Not applicable

Anxiety, Depression, and Adverse Childhood Experiences: An Update on Risks and Protective Factors Among Children and Youth.

In “The Association of Adverse Childhood Experiences with Anxiety and Depression for Children and Youth, 8 to 17 Years of Age”, we found that adverse childhood experiences (ACEs), which encompass abuse, neglect, and household dysfunction before the age of 18, were associated with significantly higher odds of anxiety and depression. 1 Elmore AL Crouch E. The association of adverse childhood experiences with anxiety and depression for children and youth, 8 to 17 years of age. Acad Pediatr. 2020; 20: 600-608https://doi.org/10.1016/j.acap.2020.02.012 Abstract Full Text Full Text PDF PubMed Scopus (37) Google Scholar Based on 2016–2017 National Survey of Children's Health data, our study provided prevalence estimates for current anxiety (9%) and current depression (4%) among children and youth. 1 Elmore AL Crouch E. The association of adverse childhood experiences with anxiety and depression for children and youth, 8 to 17 years of age. Acad Pediatr. 2020; 20: 600-608https://doi.org/10.1016/j.acap.2020.02.012 Abstract Full Text Full Text PDF PubMed Scopus (37) Google Scholar We found that 8% of children experienced 4 or more ACEs and the two most common types were parental divorce/separation (31%) and economic hardship (25%). 1 Elmore AL Crouch E. The association of adverse childhood experiences with anxiety and depression for children and youth, 8 to 17 years of age. Acad Pediatr. 2020; 20: 600-608https://doi.org/10.1016/j.acap.2020.02.012 Abstract Full Text Full Text PDF PubMed Scopus (37) Google Scholar By examining the outcomes of anxiety and depression separately, we found that the magnitude of association between nearly all ACE exposures and depression were stronger than those with anxiety. Thus, our study highlighted the importance of examining the impact of ACEs on internalizing behaviors, such as anxiety and depression, by specific condition for comprehensive pediatric prevention and treatment efforts. 1 Elmore AL Crouch E. The association of adverse childhood experiences with anxiety and depression for children and youth, 8 to 17 years of age. Acad Pediatr. 2020; 20: 600-608https://doi.org/10.1016/j.acap.2020.02.012 Abstract Full Text Full Text PDF PubMed Scopus (37) Google Scholar Since we submitted our publication in September 2019, researchers have provided updated prevalence estimates and examined the impact of ACEs on co-occurring anxiety and depression. In this progress report, we discuss literature that updates and expands our prior work.

The Dialectical Questions: Erotemata dialectices, by Philip Melanchthon, trans. and with an introduction by Jeanne Fahnestock

The Dialectical Questions: Erotemata dialectices, by Philip Melanchthon, trans. and with an introduction by Jeanne Fahnestock

Index, a history of the : conference adventures of author and indexer

Dennis Duncan’s latest book, Index, a history of the, has received much coverage since publication in September 2021, as has its index by Society of Indexers member Paula Clarke Bain. Dennis and Paula have presented at many of the main indexing conferences over the year, together and solo as author and indexer. In this article, Paula Clarke Bain reflects on their recent presentations at the Society of Indexers (UK), the American Society for Indexing (ASI) and the Indexing Society of Canada/Société canadienne d’indexation (ISC/SCI) conferences, and looks ahead to the international indexing conference in Berlin in October 2022, where they will be back presenting together again.

Applying Appraisal Theory for the Interpretation of Experienced Researchers’ Interviews on Open Access

Interviews are a recognized and valued method for obtaining research data. Usually, these data are drawn from the content of interviews. However, words and prosodic elements that accompany them may reveal complementary, and even contradictory information, that substantially alters the researcher’s first impression. After the publication in September of 2018 of the document COAlition Plan S which announced that research results funded by European institutions would have to be published in Open Access from 1 January 2020 (later postponed to 2021), 10 experienced researchers were interviewed on this topic. It is these interviews that will be the focus of this paper: the interviewees’ discourse and its meaning. To develop this research, the Appraisal Theory (Martin & White, 2005) was selected. Even though it was originally designed to study the English language, the Appraisal Theory framework proved to be very useful for analysing the researchers’ attitudes towards Open Access (OA) through several Spanish and Catalan language strategies. In addition, as interviews were audio recorded, it was decided to complement the linguistic analysis by paying attention to paralinguistic resources. The multimodal analysis of Appraisal in these researchers’ opinions reveals the dilemma they are faced with, either to publish in a limited number of less prestigious journals using Open Access, or to pay very high fees to use Gold Open Access.

Counteracting Irregular Migration in the European Union as a Priority of Poland’s Position on the New Pact on Migration and Asylum

The analysis aims to reconstruct, explain and evaluate the position of the Polish government on the essential elements of the EU migration and asylum policy proposed by the European Commission in the New Pact on Migration and Asylum. Thus, the article discusses the potential priorities and objectives of the EU migration and asylum policy from the point of view of the Polish government, articulated both during the ongoing work on the EC document (2018–2020) and after its publication in September 2020. However, the article is not intended to present the Polish government’s position on the particular, detailed solutions contained in the legislative proposals of the EC due to the New Pact on Migration and Asylum. Although, it allows identifying what the Polish side considers desirable, tolerable and acceptable, and what is utterly unacceptable in terms of the proposed changes to EU migration and asylum policy. Therefore, the main priorities of the Polish government regarding the reformed policy are indicated and explained. The first two concern counteracting irregular immigration by enhancing the protection of external borders and intensifying cooperation with third countries (in particular as concerns readmissions and returns), which means approving the postulates of the EC. At the same time, the third priority opposes the EC’s proposal addressing asylum issues.

A new version of the Journal and a new version of Sobrape

After completing 50 years of history, Sobrape began a new phase, one of great pro-activity, valuing its partners and international insertion. In order to professionalize its Journal, which was first published in 1992, we joined Dental Press, a publishing company with 31 years of history and tradition in the publication of several journals in Brazilian and world dentistry. After overcoming the challenges and achieving the objective of the first joint publication in September 2021, now we release the second issue, with great enthusiasm.

Career Crafting Training Intervention for Physicians: Protocol for a Randomized Controlled Trial.

BackgroundPhysicians work in a highly demanding work setting where ongoing changes affect their work and challenge their employability (ie, their ability and willingness to continue working). In this high-pressure environment, physicians could benefit from proactively managing or crafting their careers; however, they tend not to show this behavior. The new concept of career crafting concerns proactively making choices and adapting behavior regarding both short-term job design (ie, job crafting) as well as longer-term career development (ie, career self-management). However, so far, no intervention studies have aimed at enhancing career crafting behavior among physicians. Given that proactive work and career behavior have been shown to be related to favorable outcomes, we designed an intervention to support career crafting behavior and employability of physicians.ObjectiveThe objectives of this study were to describe (1) the development and (2) the design of the evaluation of a randomized controlled career crafting intervention to increase job crafting, career self-management, and employability.MethodsA randomized controlled intervention study was designed for 141 physicians in two Dutch hospitals. The study was designed and will be evaluated based on parts of the intervention mapping protocol. First, needs of physicians were assessed through 40 interviews held with physicians and managers. This pointed to a need to support physicians in becoming more proactive regarding their careers as well as in building awareness of proactive behaviors in order to craft their current work situation. Based on this, a training program was developed in line with their needs. A number of theoretical methods and practical applications were selected as the building blocks of the training. Next, participants were randomly assigned to either the waitlist-control group (ie, received no training) or the intervention group. The intervention group participated in a 4-hour training session and worked on four self-set goals. Then, a coaching conversation took place over the phone. Digital questionnaires distributed before and 8 weeks after the intervention assessed changes in job crafting, career self-management, employability, and changes in the following additional variables: job satisfaction, career satisfaction, work-home interference, work ability, and performance. In addition, a process evaluation was conducted to examine factors that may have promoted or hindered the effectiveness of the intervention.ResultsData collection was completed in March 2020. Evaluation of outcomes and the research process started in April 2020. Study results were submitted for publication in September 2020.ConclusionsThis study protocol gives insight into the systematic development and design of a career crafting training intervention that is aimed to enhance job crafting, career self-management, and employability. This study will provide valuable information to physicians, managers, policy makers, and other researchers that aim to enhance career crafting.International Registered Report Identifier (IRRID)RR1-10.2196/18432

The ARTP Accredited Spirometry Register: Improving the quality of diagnostic spirometry in adults, and addressing the myths and misconceptions

The proposal to create a National Register of clinicians who perform spirometry has been greeted with some trepidation. Christine Loveridge describes how the new system will work The publication in September 2016 of Improving the quality of diagnostic spirometry in adults: The National Register of certified professionals and operators ( NHSE 2016 ) has been the subject of both discussion and perhaps controversy as some see this as ‘red tape’ and hoops to jump through. This article aims to address these concerns and dispel some of the myths and misconceptions that exist around spirometry training, assessment and accreditation. It will direct those practising spirometry to the most appropriate route to accreditation. The national register document above (seen as a competence framework) will be followed in 2017 with a commissioning document which aims to overarch both the ‘how to’ guide to quality assured diagnostic spirometry ( PCC 2013 ) and the competence framework described above.

JuriGenT, un banco de datos jurídico neerlandés/español diferente

JuriGenT is a bilingual database of legal Dutch/Spanish, which is being readied for publication in September 2017. As far as translation principles are concerned, JuriGenT relies on the Skopos translation theory of Nord (1997), which implies a «documentary» translation («translation as a purposeful activity»), and on the «receiver-oriented approach» promoted by Sar ? evi ? (2000). Both theories insist on the importance of defining the role of the translator, i.e. to «represent» the source text in the source context, but in another language, as the translation has to be interpreted by the legal expert in the target context. With respect to terminological principles, the approach relies on the communicative theory of Cabre (1999) and the sociocognitive approach of Temmerman (2000). Both authors insist on the need to define the user of the database: in our case the translator and not the lawyer. These theories have led to important decisions regarding the selection of the included terminology and the conceptualization of the terminological record. Finally, JuriGenT devotes attention to user-friendly consultation, allowing easy navigation to broader terms, narrower terms and related terms in both languages.

Report on suicides of doctors under GMC investigation planned for publication in September

A report on doctors who have taken their own lives while under investigation by the General Medical Council is being prepared for publication in September. Last year the GMC announced that it was carrying out a review, led by Sarndrah Horsfall, formerly interim chief executive of the National Patient Safety Agency, into cases where doctors had killed themselves while going through fitness …

Research on Peer Review and Biomedical Publication

This issue of JAMA includes 3 reports1- 3 first presented at the Seventh International Congress on Peer Review and Biomedical Publication in September 2013.4 At the first congress, held in 1989, the most common topic of the presented abstracts was editorial peer review.5 Since then, the research presented and discussed has substantially broadened to include all aspects of biomedical publication—from research proposals to sharing data after publication.4

Well-being and the Wealth of Nations: How are They to Be Defined?

Questions relating to well-being have recently returned to the limelight, notably with the publication in September 2009 of the Stiglitz-Sen-Fitoussi commission report on the measurement of economic performance and social progress. Has this commission changed the terms of the debate on what a society's wealth and well-being are? Has it proposed new paradigms? In accepting the limitations of GDP as a key indicator of well-being, has it developed a new theoretical foundation and new evaluation criteria suited to a very different situation and to very different priorities from those that prevailed at the time when GDP first became established as a measure of national economic performance? These are the main questions raised and reviewed by this paper.

The Impact of the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) on Prescribing Practices

The Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) was a series of effectiveness trials. The results of these trials began publication in September 2005. Among other findings, these studies were interpreted to suggest that (1) second-generation antipsychotics might have fewer advantages over first-generation antipsychotics than had been generally thought; (2) among the agents assessed, olanzapine had the best efficacy outcome; and (3) after treatment failure with a second-generation antipsychotic, the most efficacious second-line medication is clozapine. To examine the actual impact on practice of these publications, we looked at change in physician prescribing behavior based on these 3 conclusions before and after publication of CATIE. Rates of antipsychotic medication prescriptions to 51,459 patients with an ICD-9 code of 295 for schizophrenia were extracted from a Missouri Medicaid claims database. χ² Tests were used to compare the rates of prescribing antipsychotic medications before and after each of 3 key CATIE publications (time 1 was September 2005, time 2 was December 2006, and time 3 was April 2006). At all time points, we demonstrated a decrease in prescriptions by all prescribers for olanzapine (P < .0001). One year after time 1, we found an increase in prescriptions by all prescribers for aripiprazole (P < .0001). No statistically significant increases in clozapine prescribing were observed. Also, a small but statistically significant increase was seen in prescriptions of perphenazine (P < .02 at time 3). However, this increase occurred only for prescriptions written by psychiatrists and not other prescribers. We found some evidence in our sample that the publication of the results from CATIE had a small but statistically significant effect on prescribing habits of psychiatrists but not other physicians in our sample population. However, larger changes occurred in prescribing behavior that were largely unrelated to the CATIE trial. We propose a hypothesis to explain the direction of observed changes.

Response to Woods and McGlashan Letter

Back to table of contents Previous article Next article Communications and UpdatesFull AccessResponse to Woods and McGlashan LetterMark Weiser, M.D.Mark WeiserRamat-Gan, IsraelSearch for more papers by this author, M.D.Published Online:1 Dec 2011https://doi.org/10.1176/appi.ajp.2011.11081276rAboutSectionsPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack Citations ShareShare onFacebookTwitterLinked InEmail To the Editor: I thank Drs. Woods and McGlashan for reading and commenting on the editorial. Their letter examines the hypothetical case of a young man with attenuated psychotic symptoms who has “an emotional crisis when his girlfriend leaves him.” Their understanding is that the symptoms “cause the patient no distress” and hence would not meet the proposed DSM-5 criteria for attenuated psychosis syndrome.In the editorial, our hypothetical patient “might be upset, have difficulty sleeping at night, have difficulties concentrating, have decreased functioning at school or at work, and have more attenuated psychotic symptoms. If this person goes to a psychiatrist presenting with this clinical picture, he might very well meet criteria for the prodromal phase.”This is clearly a description of a distressed person who seeks the help of a psychiatrist. Since criterion D of the proposed DSM-5 criteria for attenuated psychotic syndrome requires that the attenuated positive symptoms themselves must be “sufficiently distressing and disabling to the patient and/or parent/guardian to lead them to seek help,” our patient would meet the criteria.I join Drs. Woods and McGlashan in their hope that the DSM-5 field trials will help determine whether these criteria can be applied with reliability in the clinical setting.Ramat-Gan, IsraelThe author's disclosures accompany the original editorial.Accepted for publication in September 2011. FiguresReferencesCited byDetailsCited ByNone Volume 168Issue 12 December 2011Pages 1338-1338 Metrics PDF download History Accepted 1 September 2011 Published online 1 December 2011 Published in print 1 December 2011

Neurocognitive Response to Deep Brain Stimulation for Obsessive-Compulsive Disorder: A Case Report

Back to table of contents Previous article Next article Communications and UpdatesFull AccessNeurocognitive Response to Deep Brain Stimulation for Obsessive-Compulsive Disorder: A Case ReportJon E. Grant, J.D., M.D., Brian L. Odlaug, B.A., and Samuel R. Chamberlain, M.D., Ph.D.Jon E. GrantMinneapolisSearch for more papers by this author, J.D., M.D., Brian L. OdlaugMinneapolisSearch for more papers by this author, B.A., and Samuel R. ChamberlainCambridge, United KingdomSearch for more papers by this author, M.D., Ph.D.Published Online:1 Dec 2011https://doi.org/10.1176/appi.ajp.2011.11071108AboutSectionsPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack Citations ShareShare onFacebookTwitterLinked InEmail To the Editor: When obsessive-compulsive disorder (OCD) symptoms are severe and refractory to both cognitive-behavioral therapy (CBT) and medication, deep brain stimulation (DBS) may be of value (1). Although OCD research has examined the effects of DBS on cognition (2), few studies have used translational computerized paradigms capable of fractionating dissociable aspects of cognition and their neural substrates. Neurocognitive assessments have the potential to help elucidate the underlying mechanisms of action of DBS in OCD and the optimal brain target.Case Report“Mr. T” is a 30-year-old man with a 5-year history of OCD with primary contamination obsessions and washing compulsions. He had stopped socializing, had dropped out of school, and was unemployed because of his OCD. Past adequate trials of all serotonin reuptake inhibitors, both as monotherapy and with multiple augmentation strategies, and 20 weeks of CBT using exposure response prevention provided only limited benefits.After ethical review board approval, Mr. T underwent bilateral implantation of electrodes targeting the nucleus accumbens. At the time of surgery, his Yale-Brown Obsessive Compulsive Scale score was 32 while taking the following medications: clomipramine, 250 mg/day; ziprasidone, 120 mg/day; and clonazepam, 1 mg t.i.d. His medication dosages were unchanged before and after the cognitive testing.We performed cognitive assessments at baseline (prestimulation) and again 8 months after DBS began. Tasks from the Cambridge Neuropsychological Test Automated Battery included the stop-signal test (assessing ability to suppress prepotent motor responses), the intradimensional/extradimensional set shift task (examining rule learning and behavioral flexibility), and the Cambridge Gamble Task (assessing decision making). The results of these assessments are summarized in Table 1.TABLE 1. Cambridge Neuropsychological Test Automated Battery (CANTAB) Test Performance After Deep Brain Stimulation (DBS) Compared With Normative DataaMeanzIndividual TestsBefore DBSAfter DBSBefore DBSAfter DBSStop-signal test reaction time (msec)211.58204.70–1.0–0.8Stop-signal test median go reaction time (msec)449.00379.000.10.5Intradimensional/extradimensional set shift task, pre-extradimensional errors6.007.000.2–0.1Intradimensional/extradimensional set shift task, extradimensional errors1.002.000.80.6Cambridge Gamble Task, overall proportion bet0.600.570.60.4Cambridge Gamble Task, quality of decision making1.001.000.50.5a Normative data are taken from the Cambridge Cognition CANTAB database except for the stop-signal test, where data were unavailable and therefore were taken instead from Chamberlain et al. (3).TABLE 1. Cambridge Neuropsychological Test Automated Battery (CANTAB) Test Performance After Deep Brain Stimulation (DBS) Compared With Normative DataaEnlarge tableBefore the DBS, Mr. T generally exhibited cognitive performance akin to healthy comparison subjects except for evidence of stop-signal reaction time impairment (z=1.0). His stop-signal reaction time performance changed little after DBS (posttreatment z=0.8); however, the DBS resulted in significant improvement in Mr. T's OCD symptoms, and his Yale-Brown Obsessive Compulsive Scale score decreased to 10. Mr. T returned to college and now has a social life and works part-time.DiscussionThis case indicates that DBS, targeting the nucleus accumbens, was associated with significant therapeutic benefits in treatment-refractory OCD in the absence of effects on response inhibition, set shifting, or decision making. The lack of effect of accumbens DBS on the stop-signal deficit accords with translational research indicating that accumbens damage (unlike cortical damage) has no effect on response inhibition on an equivalent animal task (4). While impaired response inhibition appears to be a trait marker for OCD, and was evident in Mr. T at baseline, DBS to the accumbens does not appear to ameliorate this problem. This case illustrates the value of DBS in patients with refractory OCD and the importance of including cognitive tests in such studies to identify meaningful predictors for successful DBS in OCD on an individual level.MinneapolisCambridge, United KingdomDr. Grant has received research grants from Forest Pharmaceuticals, the National Center for Responsible Gaming, National Institute on Drug Abuse, NIMH, and Psyadon Pharmaceuticals. Mr. Odlaug reports no financial relationships with commercial interests. Dr. Chamberlain has consulted for Cambridge Cognition, P1Vital, and Shire Pharmaceuticals.Accepted for publication in September 2011.

The extended gestation and birth of the European Commission's Recommendation on the regulation of fibre networks

PurposeThe purpose of this paper is to set out the history and content of the European Commission's Recommendation on the regulation of next generation access networks, published in September 2010. The aim is to assess the Recommendation in terms of its likely impact on harmonisation and certainty of regulation within the European Union and on investment and competition.Design/methodology/approachThe approach adopted is to review the European Commission's Recommendation from the standpoint of regulatory economics.FindingsThe publication in September 2010 of the Recommendation on the regulation of next generation access networks completed a process which had begun two years and two drafts previously. The paper sets out the background to the decision to prepare a Recommendation for national regulators supervising the installation of fibre based networks, where the fibre might go either to the premises (FTTP) or to the street cabinet (FTTC). It also describes the development of the Recommendation from the first draft in September 2008 to the final draft in September 2010. It concludes that the delay in issuing the Recommendation created an interval in which national regulators pursued their own diverse policies, to the detriment of harmonisation. In terms of investment and competition, the successive drafts appear to have diminished pressure on competitors to build their own infrastructures, with consequential effects on the likely form of competition. Finally, a degree of regulatory uncertainty has been created in member states where the regulator has pursued in its market reviews of fibre access products remedies which are at odds with the Recommendation.Originality/valueThis is an early appraisal of a European Commission Recommendation which is likely to have a significant impact on European communications policy and regulation.

Reply to Fleisch et al. Letter.

Back to table of contents Previous article Next article Communications and UpdatesFull AccessReply to Fleisch et al. LetterGeorge I. Papakostas, M.D.George I. PapakostasBoston, Mass.Search for more papers by this author, M.D.Published Online:1 Dec 2010https://doi.org/10.1176/appi.ajp.2010.10091252rAboutSectionsPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack Citations ShareShare onFacebookTwitterLinked InEmail To the Editor: We are very grateful to Drs. Fleisch, Travis, and Ryan for pointing out this discrepancy, which eluded our team during the review of the article. Thus, while the Results section and Figure 2 are accurate, it appears that at some point during the development of the abstract and discussion, an error was introduced, resulting in an underestimation of the efficacy of adjunctive SAMe by 10 percentage points in terms of response and remission. We would like to clarify that the accurate response and remission rates for SAMe, according to the 17-item Hamilton Depression Rating Scale, (1) are 46.1% and 35.8%, respectively (as reported in the Results section), resulting in a number needed to treat of approximately three and four for response and remission. The same adjustment should also be made in the Discussion section. We apologize to the readers of the Journal for any confusion this discrepancy may have caused and are grateful for the opportunity to clarify our results.Boston, Mass.The authors' disclosures accompany the original article.This letter was accepted for publication in September 2010.Reference1. Hamilton M : A rating scale for depression. J Neurol Neurosurg Psychiatry 1960; 23: 56–62Crossref, Medline, Google Scholar FiguresReferencesCited byDetailsCited ByS-adenosyl methionine (SAMe) for depression in adults10 October 2016 | Cochrane Database of Systematic Reviews, Vol. 2016, No. 10 Volume 167Issue 12 December 2010Pages 1533-1533 Metrics PDF download History Accepted 1 September 2010 Published online 1 December 2010 Published in print 1 December 2010

Melancholia as a Distinct Mood Disorder? Recommendations for DSM-5

Back to table of contents Previous article Next article Communications and UpdatesFull AccessMelancholia as a Distinct Mood Disorder? Recommendations for DSM-5James H. Kocsis, M.D.James H. KocsisNew York, N.Y.Search for more papers by this author, M.D.Published Online:1 Dec 2010https://doi.org/10.1176/appi.ajp.2010.10070983AboutSectionsPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack Citations ShareShare onFacebookTwitterLinked InEmail To the Editor: In an editorial in the July 2010 issue of the Journal, Gordon Parker, M.D. (1), and a distinguished group of 16 coauthors, including one of the Deputy Editors of this journal, made an argument for melancholia being classified as a distinct mood disorder. The arguments that 1) melancholia features a cluster of symptoms with greater consistency than the broad heterogeneity of the disorders and conditions included in major depression and bipolar disorder and 2) the melancholia diagnosis has superior predictability for prognosis and treatment were not well supported by the evidence. For example, the statement that melancholic patients rarely respond to placebos, psychotherapies, or social interventions could equally well apply to severe major depression and psychotic major depression, both of which are major depression subtypes, as is melancholia, allowed as “specifiers” in the DSM-IV classification of major depression. Relevant literature reveals that hypercortisolemia is not specific to the melancholia diagnosis (2, 3). More importantly, in many studies the melancholia diagnosis lacks predictive value for treatment selection, including response to antidepressant medications or differential predictive value for response across classes of antidepressants (4, 5). Because each of the specifiers designated in DSM-IV shares characteristics with the larger domain of major depression and yet each has its own distinctive qualities (for melancholia it is a characteristic cluster of symptoms), it makes sense to retain the current system in DSM-5.New York, N.Y.Dr. Kocsis has received research grant support from the Agency for Healthcare Research and Quality, the National Institute of Mental Health, the National Institute on Drug Abuse, AstraZeneca, Burroughs Wellcome Trust, CNS Response, Forest, Pritzker Consortium, and Roche; he has served on the speaker's bureaus of AstraZeneca, Merck, Pfizer, and Wyeth; and he has served on the advisory boards of Neurosearch, Pfizer, and Wyeth.This letter was accepted for publication in September 2010.