To evaluate demographic trends of open globe injuries (OGIs) using a large dataset representative of United States population. Retrospective cross-sectional observational study using theNational Inpatient Sample (NIS) database from 2002 to 2013. Only patients witha primary admitting diagnosis of OGI wereincluded. Data included age (in years), gender, race, type of OGI, death rate and length and cost of stay. During the 12-year period, 27,467 adults (age > 20) with acute OGIswere admittedtotheUS hospitals.Theincidence ofOGIs in the adult US populationwas10.6 cases per 1,000,000 persons. The mean age was 50.4 years (SD 21.52); the average ages of men and women were 44.34 (SD 17.63) and 65.69 (SD 22.77), respectively. Men accounted for 71% of all cases, with84% of patients under 60. A decrease inthenumber ofOGIs was seenwith advancing age in men, whereas the opposite was true for women. Men, elderly over 80 andBlacks were at the highest risk of sustaining an OGI. The most and least common types of injuries were penetrating injuries (73%) and IOFBs (11%),respectively. Over half of young adults in the 21-40 cohort and 43% of men were uninsured (p < 0.001). Theaverage length ofhospital stay increased with ageandwassignificantly much higher in women than men (3.4 vs2.5 days). Racial, gender and age disparities are prevalent in patients with OGIs. Although themajority of cases were seen in Whites and young men age 21-40 years, the incidence of OGIs per 1,000,000 persons per year was thehighest in Blacks and Hispanics, elderly over 80, and men. One-third of all cases were uninsured. These disparities should be the basis of future public health safety measures.