Research Institute Research Articles

Nutritional Evaluation of Short-horned Grasshopper (Oxya hyla hyla Serville) as a Substitute for Soybean Meal in Compound Diets of Rohu (Labeo rohita Hamilton)

The growth effects of partial substitution of soybean meal for grasshopper meal (Oxya hyla hyla) in compound diets of Rohu fish (Labeo rohita) were evaluated for 75 days at the aquaculture research center in IAAS, Paklihawa Campus with 16 meshed cages of 1 m3 size, stocked with 12 fingerlings. Completely Randomized Design was used with 4 treatments and 4 replications. Treatments included the incremental substitution of Soybean meal (SM) for Grasshopper meal (GM) as 0% GM, 10% GM, 20% GM and 30% GM. Feeding rates were adjusted every month based on observed body weight. Fish parameters were observed at 16, 27, 45, 60 and 75 days after stocking, whereas, the physical water parameters were observed daily. During the study period, the recorded mean water temperature, pH, dissolved oxygen and survivorship were 19°C, 8.2, 6.4 mg/L and 64.6% respectively. Average growth rate, relative growth rate, specific growth rate, daily weight gain and protein efficiency ratio showed no significant difference (p>0.05) among the treatments. The Feed Conversion Ratio of 20% GM and 30% GM were statistically similar and superior to 0% GM and 10% GM as well. To sum up, we did not have enough evidence to prove the superiority of grasshopper meal incorporated diet on rohu, perhaps because of a lower feed efficiency.

A Map of Research on Spinoza in Brazilian Universities

This paper presents a profile of the research on Spinoza’s philosophy in Brazil, providing information concerning the beginning of the academic work, its place of origin and influence, the leading training centers, and the aspects of Spinoza’s philosophy that are most studied. First, it presents a brief history of Spinoza’s presence in Brazil and the beginning of academic studies on the author. Next, data is shown on the current state of training of philosophy researchers on Spinoza in Brazil. The data was obtained from the CNPq Lattes Platform, which brings together information on all Brazilian researchers affiliated with universities and research institutes. Spinoza’s philosophy was absent from intellectual circles in Brazil during the colonial period and started to be mentioned in Brazil only in the nineteenth century. Only with the strengthening of universities in the twentieth century did Spinoza become the object of investigation by many researchers.

Misconducts in research and methods to uphold research integrity.

Research misconduct refers to deliberate or accidental manipulation or misrepresentation of research data, findings, or processes. It can take many forms, such as fabricating data, plagiarism, or failing to disclose conflicts of interest. Data falsification is a serious problem in the field of medical research, as it can lead to the promotion of false or misleading information. Researchers might engage in p-hacking - the practice of using someone else's research results or ideas without giving them proper attribution. Conflict of interest (COI) occurs when an individual's personal, financial, or professional interests could potentially influence their judgment or actions in relation to their research. Nondisclosure of COI can be considered research misconduct and can damage the reputation of the authors and institutions. Hypothesis after results are known can lead to the promotion of false or misleading information. Cherry-picking data is the practice of focusing attention on certain data points or results that support a particular hypothesis, while ignoring or downplaying results that do not. Researchers should be transparent about their methods and report their findings honestly and accurately. Research institutions should have clear and stringent policies in place to address scientific misconduct. This knowledge must become widespread, so that researchers and readers understand what approaches to statistical analysis and reporting amount to scientific misconduct. It is imperative that readers and researchers alike are aware of the methods of statistical analysis and reporting that constitute scientific misconduct.

Evaluation of Shoulder Risk Factors in the Repetitive Task of Slaughterhouse

Repetitive movements and the speed of upper limbs increase the risk of musculoskeletal disorders. This study aimed to analyse the risk of shoulder injuries in repetitive tasks by evaluating the humerus angle, angular velocity, and angular acceleration during simulated chicken wing cutting. The study was conducted in a laboratory simulating a real environment. Thirty-six healthy right-handed volunteers were assessed using an electromagnetic tracking device, TrakSTAR, integrated with MotionMonitor™ (Innovative Sports Training, Inc. Chicago, IL) and software to collect 3-D kinematic data developed in the research centre. The equipment measured the angles performed by the upper limbs during the entire movement. The humerus angles were automatically transformed into angular velocity (°·s−1) and angular acceleration (°·s−2). Maximum angular velocities were 27.39°·s−1 (men, right humerus) and 22.39°·s−1 (women, left humerus), both below the safe limit. Maximum accelerations were 25.32°·s−2 (men, left side) and 28.94°·s−2 (women, left side); safety values for these accelerations are not established. Monotony is a risk factor, especially for the dominant side. Future studies should evaluate risk factors simultaneously in repetitive tasks. Repetitiveness exceeds the safe limit according to the OCRA method.

GLUTENIN DIVERSITY OF FLOUR WHEAT (Triticum aestivum L.) FOR COOKIE QUALITY IN MEXICO

Glutenins are high- and low-molecular-weight proteins (HMW-G and LMW-G). They play a determining role in genetic improvement to define industrial quality in flour wheat, so understanding their variability is necessary for directing selection toward a specific quality. The objective of this research was to determine the diversity of HMW-G and LMW-G alleles of genotypes from the flour wheat breeding program of the National Institute of Forestry, Agricultural, and Livestock Research (INIFAP) useful for cookie quality. Twenty-five genotypes were used, including six Mexican cookie varieties, as well as 21 genotypes introduced from an international collection of accessions from the International Maize and Wheat Improvement Center (CIMMYT). HMW-G and LMW-G were identified based on their separation on polyacrylamide gels in the presence of sodium dodecyl sulfate. For HMW-G, the 2* variant in Glu-A1 was the most frequent variant for the trial and introduction nursery, with more than 80 %. At the Glu-B1 locus, the 7+9 and 7 variants were the most frequent, with 60 and 38.1 % in trial and nursery, respectively. For Glu-D1, the 2+12 variant was the most frequent in the trial with 64 %, and 5+10 with 85.7 % in nursery. The latter allele favors baking quality. For the Glu-A1 and Glu-D1 loci, it is necessary to introduce genotypes with null alleles or with the 2+121 variant in Glu-D1 associated with cookie quality. For the highest-frequency variants of LMW-G, c in Glu-A3, h in Glu-B3, and b in Glu-D3 are associated with baking quality. With the aforementioned, it is concluded that there is a low frequency and little variation in useful alleles of HMW-G and LMW-G for cookie quality in the introduced accessions analyzed, implying that new genetic sources that favor it should be explored.

UK research priority setting for childhood neurological conditions.

To identify research priorities regarding the effectiveness of interventions for children and young people (CYP) with childhood neurological conditions (CNCs). These include common conditions such as epilepsies and cerebral palsy, as well as many rare conditions. The National Institute for Health and Care Research (NIHR) and the James Lind Alliance (JLA) champion and facilitate priority setting partnerships (PSPs) between patients, caregivers, and clinicians (stakeholders) to identify the most important unanswered questions for research (uncertainties). A NIHR-JLA and British Paediatric Neurology Association collaboration used the JLA PSP methodology. This consisted of two surveys to stakeholders: survey 1 (to identify uncertainties) and survey 2 (a prioritization survey). The final top 10 priorities were agreed by consensus in a stakeholder workshop. One hundred and thirty-two charities and partner organizations were invited to participate. In survey 1, 701 participants (70% non-clinicians, including CYP and parent and caregivers) submitted 1800 uncertainties from which 44 uncertainties were identified for prioritization in survey 2; from these, 1451 participants (83% non-clinicians) selected their top 10 priorities. An unweighted amalgamated score across participant roles was used to select 26. In the final workshop, 14 health care professionals, 11 parent and caregivers, and two CYP ranked the 26 questions to finalize the top 10 priorities. Ten top priority questions were identified regarding interventions to treat CYP with CNCs and their associated comorbidities, for example, sleep, emotional well-being, and distressing symptoms. The results of this study will inform research into the effectiveness of interventions for children with neurological conditions.

Validation of the Maslach Burnout Inventory-General Survey 9-item short version: psychometric properties and measurement invariance across age, gender, and continent

BackgroundThe Maslach Burnout Inventory-General Survey (MBI-GS) stands as the preeminent tool for assessing burnout across various professions. Although the MBI-GS9 emerged as a derivative of the MBI-GS and has seen extensive use over several years, a comprehensive examination of its psychometric properties has yet to be undertaken.MethodsThis study followed the Standards for Educational and Psychological Testing guidelines to validate the MBI-GS9. Employing a combined approach of classical test theory and item response theory, particularly Rasch analysis, within an integrated framework, the study analyzed data from 16,132 participants gathered between 2005 and 2015 by the Centre for Organizational Research at Acadia University.ResultsThe findings revealed that the MBI-GS9 exhibited satisfactory reliability and validity akin to its predecessor, the MBI-GS. Across its three dimensions, Cronbach’s α and omega coefficients ranged from 0.84 to 0.91. Notably, the MBI-GS9 displayed no floor/ceiling effects and demonstrated good item fit, ordered threshold, acceptable person and item separation and reliability, clear item difficulty hierarchy, and a well-distributed item threshold. However, the results suggested a recommended minimum sample size of 350 to mitigate potential information loss when employing the MBI-GS9. Beyond this threshold, the observed mean difference between the MBI-GS and MBI-GS9 held minimal practical significance. Furthermore, measurement equivalence tests indicated that the MBI-GS9 maintained an equivalent three-factor structure and factor loadings across various gender, age, and continent groups, albeit with inequivalent latent values across continents.ConclusionIn sum, the MBI-GS9 emerges as a reliable and valid alternative to the MBI-GS, particularly when utilized within large, diverse samples across different age and gender demographics. However, to address potential information loss, a substantial sample size is recommended when employing the MBI-GS9. In addition, for cross-cultural comparisons, it is imperative to initially assess equivalence across different language versions at both the item and scale levels.

Primerjalna ocena hranilne in nehranilne kakovosti je odkrila, da ima sladki krompir z belim založnim parenhimom boljše lastnosti kot tisti z oranžnim

Recent introduction of beta-carotene rich orange-fleshed sweet potatoes (OFSP) has resulted to consumers’ low demands for traditional white-fleshed sweet potatoes (TWFSP), without due consideration of their nutritional qualities. This study appraised the nutritional compositions of OFSP and TWFSP. They were analyzed for mineral content, antinutrients, and phytochemicals at National Root Crops Research Institute, Umudike. The field experiment was conducted using randomized complete block design with three replicates. TWFSP showed higher concentrations of minerals, anti-nutrients and phytochemicals than OFSP. In TWFSP, potassium ranged from 1879.20 ± 0.01 mg kg-1 (‘B3V3’) to 1960.30 ± 0.01 mg kg-1 (‘B2V2’) while in OFSP it varied from 1162.60 ± 0.02 mg kg-1 (‘B26T26’) to 1800.20 ± 0.01 mg kg-1 (‘B10T10’). The antinutrients and phytochemicals results showed that flavonoids in TWFSP ranged from 0.30 ± 0.01 mg TAE kg-1 (‘B1V1’) to 970.50 ± 0.02 mg TAE kg-1 (B3V3) while it varied from 0.20 ± 0.01 mg TAE kg-1 (‘B4T4’) to 670.30 ± 0.01 mg TAE kg-1 (‘B8T8’) in OFSP. Heritability estimates were high for all antinutrients and minerals while genetic advance was high only for potassium (42.206) and phosphorus (10.288) traits. Variation between phenotypic coefficient of variation and genotypic coefficient of variation was negligible, with the former higher for most minerals and antinutrients. TWFSP were found richer than OFSP, and suggests improvement by selection.

Morphological characterization of shallot (Allium cepa L. var. aggregatum) segregating populations obtained from natural-outcrossing in Ethiopial-outcrossing in Ethiopia

Shallot is a vegetable and condiment crop widely used in Ethiopia and globally. However, absence of improved and adaptable varieties has been the major cause of low productivity. Narrow genetic base of local shallot germplasm owing to vegetative reproduction of the crop, among others, has been the root cause of low productivity. Nevertheless, some plants within the germplasm were observed bolting and producing viable seeds, presenting an opportunity for genetic diversification. Consequently, a germplasm enhancement program was initiated using these naturally outcrossing genotypes where about eighty-one genotypes were generated. The present study was thus undertaken with the objective of characterizing, classifying, and selecting the eighty-one genotypes for future breeding activities. The genotypes were planted in 9x9 simple lattice design with two replications at Debre Zeit Agricultural Research Center (Ethiopia) during the dry (irrigated) season of 2021. The genotypes were evaluated for fifteen growth, yield, and quality traits. Significant variations were observed among the genotypes in terms of bulb yield, bulb height and diameter, total soluble solids, bolting percentage, and bulb skin color. Bulb yield of the genotypes ranged from 31.33 t/ha in DZSHT-79-1A to 9.63 t//ha in DZSHT-45-1A-1. DZSHT-51-2 (207.93 g) was the highest yielder per plant whereas DZSHT-065-6/90 (74.51 g) was the lowest yielder. DZSHT-14-2-1/90 had the thickest bulb (44.69 mm) significantly thicker than twenty two genotypes which had bulb diameter ranging from 28.92 mm to 20.29 mm. DZSHT-81-1/90 was a genotype with the longest bulb height (52.33 mm) while DZSHT-147-1C was a genotype with the shortest bulb (33.12 mm). DZSHT-307-1/90 had the highest TSS (16.78°Brix) significantly differing from DZSHT-002/07 which had the lowest TSS (11.17 °Brix). Dry matter of the genotypes ranged from 12.00% to 22.79%. DZSHT-004/07, DZSHT-111-2-1, DZSHT-41-2B and DZSHT-72-2 had DM% greater than 20% which coupled with greater than 14 °Brix could make them suitable for dehydrated shallots. Among the 81 genotypes characterized 4 (4.9%), 7 (8.6%), 13 (16.1%), 28 (34.6%) and 29 (35.8%) were yellow, golden, light red, red and dark red in colour, respectively. Fifteen of the genotypes had at least 50% bolting plants whereas twenty nine of the genotypes had less than 25% bolting. The results revealed that seven principal components explained approximately 76% of the observed variation. Cluster analysis grouped the genotypes into seven clusters, with the majority falling into three clusters. The study successfully identified genotypes with diverse and important traits and availed both the genotypes and the information for future breeding programs. These genotypes could be used for the development of improved hybrid and open pollinated shallot varieties with higher yield, quality and pest resistance/tolerance attributes.

Assessment of Genetic Variability, Correlation, and Path Coefficient for Yield and Its Contributing Traits in Pigeon Pea [Cajanus cajan (L.) Millspaugh

The experimental material consisted of 155 pigeon pea genotypes sown in a Randomized Block Design (RBD) with three replications during the Kharif, 2023-2024 crop season at the N. E. B. Crop Research Centre of G. B. Pant University of Agriculture and Technology, Pantnagar, Uttarakhand. The genetic variance components, correlation, and path coefficient for seed yield and its components were estimated using these 155 pigeon pea genotypes. The highest phenotypic coefficient of variation (PCV) values (> 20%) were recorded for traits such as the number of pods per plant (26.45%), number of secondary branches per plant (22.72%), and seed yield per plant (20.27%). In contrast, the lowest PCV estimates (< 10%) were found for days to maturity (7.39%) and days to 50% flowering (6.73%). High estimates of the genotypic coefficient of variation (GCV) (> 20%) were recorded only for the number of pods per plant (23.6%). The lowest GCV estimates (< 10%) were observed for hundred seed weight (9.63%), number of seeds per pod (9.55%), plant height (9.49%), pod length (7.18%), days to maturity (6.85%), and days to 50% flowering (6.5%). The hundred seed weight showed a high positive direct effect on seed yield per plant (Genotypic = 0.58, Phenotypic = 0.47) along with a positive and significant correlation (Genotypic correlation coefficient, (rg = 0.599); Phenotypic correlation coefficient, (rp = 0.485)). Based on this investigation, it is evident that exploring genetic variability, correlations, and path analyses provides a more effective approach for selecting superior cultivars for yield and related traits.

Retracted] MicroRNA‑30e inhibits adhesion, migration, invasion and cell cycle progression of prostate cancer cells via inhibition of the activation of the MAPK signaling pathway by downregulating CHRM3.

Following the publication of the above article, a concerned reader drew to the Editor's attention that certain of the Transwell invasion assay data shown in Fig. 7B on p. 451 were strikingly similar to data that had appeared in Fig. 3D in a previously published paper written by different authors at a different research institute, which had been received at the journal Cancer Letters at around the same time, and which has subsequently been retracted [Gu J, Wang Y, Wang X, Zhou D, Shao C, Zhou M and He Z: Downregulation of lncRNA GAS5 confers tamoxifen resistance by activating miR‑222 in breast cancer. Cancer Lett 434: 1‑10, 2018]. In addition, there were potentially anomalous features associated with the western blot and cell cycle data in this paper. In view of the fact that certain of the data in the above article were also submitted to a different journal within the space of a few days, the Editor of International Journal of Oncology has decided that this paper should be retracted from the publication. The authors were asked for an explanation to account for these concerns, but the Editorial Office did not receive a reply. The Editor apologizes to the readership for any inconvenience caused. [International Journal of Oncology 54: 443‑454, 2019; DOI: 10.3892/ijo.2018.4647].

Knowledge Mapping for the University: Analysis of Approaches and an Example of Its Use

The purpose of the article is to analyze the current research, development and application of knowledge maps for visualizing heterogeneous, disparate, and often hidden knowledge in universities, and discuss the features of the development of maps in higher education institutions.Materials and methods. The market for intellectual services is actively developing in Russia and worldwide, and the methods of express assessment of human capital are extremely relevant. The intellectual capital of universities is one of the most important assets in the dynamic market of educational and consulting services. Research institutes and universities are modern centers of knowledge and technology, where lecturers and researchers accumulate, transfer and produce knowledge, multiplying and replenishing explicit and implicit intellectual assets. Knowledge management helps educational and research organizations to solve the problems of managing intellectual capital, gain a competitive advantage, improve management efficiency, and reduce risks caused by the concentration of knowledge among a small number of experts. The article is devoted to the problem of analyzing new opportunities for promoting and monetizing the intellectual capital of universities through visualization and knowledge mapping. Knowledge maps of university lecturers are a relevant tool to improve the quality of research and marketing communications, as well as positioning in the market of consulting and intellectual services. Knowledge maps of educational institutions and research teams are of particular research interest, since there is no characteristic business desire to protect knowledge from transfer and reproduction in this field.The result of the study is a typology of knowledge maps, which helps to identify patterns, structures and elements necessary for the development of knowledge bases in universities. The authors based on the results of a pilot study give examples of specific maps. Based on an analysis of existing approaches to the typology of knowledge maps and Bloom’s taxonomy, a hierarchical model reflecting different levels of understanding when interpreting and using knowledge maps was developed. The main research methodology relies on fairly well developed and widely used in the world practice knowledge engineering methods – knowledge extraction, structuring and formalisation. A separate analysis of potential consumers (or stakeholders) of knowledge maps was carried out based on stakeholder theory.Conclusions. The article discusses the methodological aspects of the development and features of the practical application of knowledge maps in higher educational institutions. Knowledge analysis makes it possible to develop the organizational “memory” of a university, collecting strategic knowledge and identifying critical knowledge, and generally enriches the knowledge structure. Knowledge maps as a category of special visual tools used to analyze the knowledge and competencies of university lecturers can improve the process of managing employee competencies, management decision making, and thereby reducing cognitive load. Such maps increase the image and marketing performance of a university in the educational services market, and make the professional landscape of knowledge more transparent.

Application of seaweed liquid extract improves the growth, yield, and chemical constituents of lemongrass

The rapid increase in the adoption of seaweed-based bioproducts in crop production systems can be attributed to their unique bioactive components and significant beneficial effects. In the growing interest of sustainable agricultural practices, the present study aims to reduce the dependency on chemical fertilizers while enhancing crop productivity and quality through seaweed extract. A field experiment was carried out during 2018-2019 and 2019-2020 at CSIR-CIMAP, Allalasandra, Research Center, Bengaluru to study the influence of seaweed liquid extracts as a foliar application on growth, yield, and chemical composition of lemongrass. Results revealed that the growth, herb and essential oil yield of lemongrass was improved significantly by the application of Kappaphycus alvarezii (K sap) at 20% concentration, recording herb and oil yield of 35.86 t ha−1 year−1 and 466.70 kg ha−1 year−1, respectively when conjugated with a recommended dose of fertilizer (RDF), compared to RDF alone, 30.40% and 35.70% in herb and oil yields, respectively, were recorded in this treatment. Notably, the treatment 50% RDF + K sap applied at 7.5% concentration was statistically at par with RDF with respect to the herb as well as oil yield connoting considerable scope of reducing chemical fertilizer requirement for the lemongrass. The functional relationship between herb and oil yield of lemongrass with different concentrations of seaweed sap applied at different crop stages was found to be strongly correlated (r2=0.99 and r2=0.98, respectively). Higher amounts of citronellal (0.70%) Borneol (1.10%), α-Terpineol (1.90%), and Citronellyl acetate (0.4%) were recorded in 20% K sap spray with RDF. The study revealed that the application of marine alga Kappaphycus alvarezii foliar spray above the 10 - 20% concentration significantly increased the herb, essential oil yield, and chemical constituents of lemongrass.

Enhancing Corn Yield and Soil Quality in Irrigated Semiarid Region with Coal Char and Biochar Amendments

Sustainable use of croplands is facing a challenge to maintain organic carbon (C) in soil. Pyrolyzed coal or coal char (CC) is a porous C material produced from the pyrolysis of coal containing high organic C, large surface area, and low bulk density like biochar (BC). This study evaluates corn (Zea mays L.) grain yield and selected soil properties in soil amended with CC and BC at two rates (22 and 44 Mg ha−1) with farmyard manure (FM) (66 Mg ha−1) and without FM addition. This field experiment was performed in sandy loam soil at the University of Wyoming’s Sustainable Agricultural Research and Extension Center (SAREC), Lingle, WY, USA. Two years of field study results indicated CC and BC applied at 22 Mg ha−1 with FM resulted in significantly greater average corn grain yields (13.04–13.57 Mg ha−1) compared to the no char’s treatment (11.42 Mg ha−1). Soil organic matter (SOM) content was significantly greater in the higher application rates of CC and BC than in treatments without chars. Overall, soil nitrate nitrogen (NO3-N), phosphorous (P), and potassium (K) were found significantly greater in CC and BC co-applied with FM treatments. Soil water-holding capacity (WHC) significantly improved in sandy loam soil (up to 27.6% more than the no-char treatment) at a greater concentration of char materials. This study suggests that char materials applied at a moderate rate (22 Mg ha−1) with FM can improve soil properties and crop yield.

Improving Children’s Services Engagement of Fathers in Child Protection: Logic Model for an Organisational Development and Staff Training Intervention

AbstractThere is a long-standing and ongoing problem of practice with at-risk families in child welfare work focusing primarily on mothers and failing to properly engage fathers. The article describes a child welfare innovation from the UK designed to tackle this issue—the ISAFE (Improving Safeguarding through Audited Father-Engagement) intervention, developed by The Fatherhood Institute and The Children’s Social Care Research and Development Centre (CASCADE) at Cardiff University and based on two previous separate interventions which had positive initial evaluations. ISAFE combines in-service social work practitioner training with other elements of organisational development to improve the engagement of fathers. Activities targeting organisational culture are case file audits, identification and training of team champions, and a webinar for service leaders. The practitioner training involves both awareness raising about the importance of engaging men and skills development via an introduction to motivational interviewing. ISAFE’s theory of change is summarised in the form of a logic model. Limitations of the intervention and its evaluation are discussed.

Risk assessment of clinical trial protocols: a tool for hospital pharmacists to reduce human error in experimental drug management

Background and objectivesHospital pharmacists collaborate in clinical trials by managing the reception, conservation, distribution, return and destruction of the investigational medical products (IMP). However, errors can happen during the simultaneous...

Production of Steroid Hormones in Galena Opava

The drug product Antigest of the company Spofa was launched as soon as in 1965 and Czechoslovakia thus became forth country in the world where oral anticonception was introduced. The gestagen component of Antigest was methenmanidon acetate (superlutin), an original substance developed in the Research Institute of Natural Drugs. Superlutin and some other steroid drugs were produced in the Galena Opava plant. In the article, all the syntheses utilized in the manufacture of steroid drugs in Galena are described and the reasons why the manufacture of steroid drugs was terminated at the beginning of eighties are explained.

Assessment of the impact of physical and chemical factors of the production environment on the morphological state of target organs in an animal experiment

The study of the morphological state of target organs of outbred (nonlinear) laboratory mice ICR (CD-1), which were under prolonged dynamic influence of physical and chemical factors of the production environment under model conditions, is of wide research interest, as it allows to assess the impact of these factors at the tissue and cellular level and to identify the presence of pathological changes in relation to the group control that was not exposed to the studied factors of the production environment during the 90-day experiment, which has clinical and practical significance. When assessing the 90-day dynamics (from 0 days – 6 months (background) to 30–60–90 days – 7–8–9 months) of the impact of environmental factors on the morphological state of tissues and organs of outbred (nonlinear) laboratory mice ICR (CD-1), generally accepted and unified methods were used. Animals (weighing 45–50 gr., sexually mature age – 6 months) were divided into 3 experimental groups (vibration exposure, noise exposure, chemical exposure) of 30 individuals each (15 females and 15 males) and 1 control group (15 females and 15 males), kept in standard comfortable conditions, and not exposed to the factors of the production environment. The experiment was conducted in accordance with the rules adopted by the European Convention for the Protection of Animals Used for Experimental Scientific Purposes (Strasbourg, 1986), after approval by the Ethical commission of the Novosibirsk Research Institute of Hygiene of Rospotrebnadzor. Statistical processing of the research materials was carried out using standard Statistica 10.0 application programs. The morphological analysis of the target organs of experimental animals revealed the presence of a complex of pathological changes in the 90-day dynamics of the impact of factors of the production environment, compared with the morphological state of the organs in the control group. The results obtained have clinical and practical significance, as they allow us to justify preventive measures aimed at preventing the negative impact of long-term production factors on the labor contingent. Further study of the morphological state of target organs of ICR laboratory mice exposed to prolonged dynamic exposure to physical and chemical factors of the production environment under model conditions will contribute to the establishment of mechanisms for the development of occupational diseases and the development of scientifically based medical and hygienic measures aimed at preserving the health of the labor contingent in the management of labor longevity.

Hydraulic investigation of flows at high-head overflow spillway with multiple aerators: a physical and numerical study of Mohmand Dam, Pakistan

ABSTRACT A spillway is the essential part of the dam body, which releases surplus flows. At higher floods, the spillway operates at high heads, which results in high flow velocities along the chute and may cause negative pressures and cavitation. Therefore, to minimize such issues, aerators are provided along the spillway's chutes. This study aims to analyze the performance of the high-head overflow spillway of Mohmand Dam, Pakistan, having a steep chute of 32° with multiple aerators. Based on Froude's law of similitude, the physical model study was carried out at Irrigation Research Institute, Nandipur, on a scale of 1:60, while FLOW-3D numerical models were used to compare different hydraulic parameters, i.e., flow depth, velocity and pressure. The numerical models were validated with the results of a physical model, which were found in an acceptable range (i.e., 4.93%), and the hydraulic performance of two aerators was evaluated at different discharges. The models indicated negative pressures inside the aerator cavity, which allowed the suction of air to the lower nappe. The maximum air entrainment at the first aerator was about 8.5%. The results also showed that air entrainment to the lower nappe decreased when discharge was increased, whereas the maximum air detrainment reached 11.3% downstream of the second aerator.

Controlled Rummage Approaches for Bummock: Tennyson Research Centre

Controlled Rummage Approaches for Bummock: Tennyson Research Centre