Introduction. The transformation of our country's healthcare system is impossible without quality medical reform. One of the reform's starting directions is improving the provision of cardiac care to the population. Aim. Medical and social substantiation of directions for developing a conceptual model of a regional cardiology centre based on the principles of public-private partnership (on the example of the Kyiv region). Materials and methods. Data from state and industry statistical reports of healthcare institutions of the Ministry of Health of Ukraine and data from the State Statistics Service of Ukraine, as well as materials from a sociological survey of cardiologists and patients and a survey of 31 experts (highly qualified health care organizers) conducted according to specially developed programs) were the materials in this study. The research used complex methods: systematic approach and analysis, synthesis, generalization, interpretation, medical-statistical and sociological method, expert assessment and conceptual modelling method. Results. Stable high levels of circulatory system disease prevalence among the adult population of the Kyiv region and differences depending on different age groups, increase in the mortality rate due to cardiovascular diseases (CVD) in the studied time intervals and the mortality rate of cardiac patients were established. At the same time, there was a decrease in the level of hospitalization of patients along with a decrease in the average number of beds for the treatment of cardiology patients; there were no significant changes in the staffing indicators of health centres of the Kyiv region, which provide cardiac medical care to patients with CVD in 2018-2022. However, there was an increase in the number of cardiovascular surgeon positions for the adult population of the Kyiv region in 2020 by 12.9%, and then a decrease of 7.01% in 2021. The insufficient resource provision of healthcare facilities in which cardiac medical care is provided as evidenced by a significant decrease in the coverage of echocardiography in the study, despite the reform of the network of healthcare facilities in the region. The results of the survey of patients and cardiology specialists revealed significant levels of dissatisfaction with the possibilities of providing and receiving quality cardiology care. Conclusions. A range of problems in the field of providing high-quality cardiac care to the population was determined on the example of the Kyiv region, and a strategy with phased and complex steps to solve the most acute problematic issues was proposed with the proposed project of the Strategic Plan for the development of the regional system of cardiac care for the population of the region for the period 2024-2029.