To evaluate clinical outcomes (restoration survival, technical and biological complications), and patient-reported outcome measures (PROMs) of full mouth rehabilitation with minimally invasive glass-ceramic restorations after up to 12 years of clinical service. Twenty individuals (12 females, 8 males) received full-mouth rehabilitation with minimally invasive tooth-supported glass-ceramic restorations during the years 2009 - 2017 and agreed to participate in a follow-up visit. Full dental and periodontal examinations were completed, and the restorations were evaluated according to United States Public Health Service (USPHS) criteria. Kaplan-Meier was used for analysis of the survival time. The patients received 439 minimally invasive restorations made from lithium disilicate reinforced glass-ceramic (79.7%), feldspathic porcelain (17.5%) and leucite reinforced glass-ceramic (2.7%). Restoration design included occlusal and buccal surface partial coverage restorations (35.3%), full-contour restorations (31.2%), veneers (27.8%), onlays (4.6%) and inlays (1.1%). The mean follow-up time from restoration insertion was 4.5 years (1.5-12.4 years). Five patients lost altogether 13 restorations during the follow-up time. The estimated cumulative Kaplan-Meier 5-year survival rates were 96.6% on the restoration level and 86.4% on the patient level. Major technical complications amounted to 3% (n=13) of the restorations, including larger chippings (n=5) and loss of retention (n=7). Biological complications were observed at a rate of 4.3%. Patients were very satisfied with esthetics (VAS 9.5) and function (VAS 9.3) of the restorations. Minimally invasive full-mouth rehabilitation with glass-ceramic restorations resulted in high survival rates, few complications and a high level of patient satisfaction over a mid-term time-period. There is an increasing trend toward minimally invasive restorations, as previous studies indicate that these designs preserve healthy tooth structure, leading to fewer biological complications. The present study demonstrates that minimally invasive restorations can be reliably used in full-mouth rehabilitations.
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