Abstract: Urbanization and economic growth are key players in molding the societal fabric of the ASEAN-5 nations, thus directly affecting life expectancy. Hence, this study utilizes the Fully Modified Ordinary Least Square (FMOLS) approach to investigate the impact of health expenditure, economic growth, urbanization, and CO2 emissions on life expectancy in the ASEAN-5 countries from 1995 to 2020. The findings indicate that increased health expenditure and economic growth positively contribute to enhanced life expectancy in the region, highlighting the importance of healthcare investments and sustained economic development. However, the observed negative impact of urbanization underscores potential health challenges associated with rapid urban development, necessitating strategic urban planning. Policymakers are encouraged to prioritize healthcare budgets, focusing on infrastructure and accessibility, while fostering economic initiatives for indirect health benefits. Mitigating potential health risks linked to urbanization requires investments in healthcare facilities, sanitation, and public health awareness programs. This study offers nuanced insights for policymakers in formulating effective strategies to balance economic development with public health priorities in the ASEAN-5 countries. Keyword: urbanization, economic growth, life expectancy, FMOLS