PU Films Research Articles

Polycaprolactone triol-based polyurethane film conjugated ibuprofen to sustained release: Synthesis, physicochemical, cytotoxic, and release studies

Polyurethanes are among the most ubiquitous materials in the biomedical and pharmaceutical areas. Thus, in this study, polycaprolactone-triol-based polyurethane conjugated ibuprofen (coded as PU-ibu) was synthesized by a two-step condensation method and characterized according to composition, morphological, thermal, and mechanical. In addition to wettability, hemocompatibility, cytotoxicity, and in vitro release. In addition to wettability, hemocompatibility, cytotoxicity, and in vitro release. The synthesized PU film had a smoother surface and superior mechanical properties compared to PU-ibu film.Moreover, PU was capable of swelling in PBS while PU-ibu film exhibited a surprising “de-swelling” behavior. Additionally, PU-ibu film not only had adequate wettability, excellent hemocompatibility, and sustained delivery capability but also greatly enhanced the proliferation of fibroblast cells. Therefore, the PU-ibu film provides a potential novel system for sustained drug delivery.

Multifunctional fireproof electromagnetic shielding polyurethane films with thermal management performance

A multifunctional polyurethane film (PU) with superior electromagnetic shielding performance, joule heating performance, thermal conductivity and flame retardancy has been carefully designed. The ammonium polyphosphate (APP) wrapped with conductive MXene (MAPP) is prepared by microencapsulation technology and added in PU solution for enhancing the electric conductivity of PU/graphite fiber (GF) film. The three-dimensional (3D) conductive network composed of GF and MAPP promotes electron transmission efficiency and electromagnetic (EM) wave dissipation through multiple absorbtion and reflection. Compared with the PU/GF film, the electric conductivity and thermal conductivity of PU/GF/MAPP film enhanced by 57.7% and 59.3%, respectively. What’s more, the PU composite film shows excellent mechanical properties, joule heating performance and high fire safety performance. Therefore, the prepared multifunctional PU film demonstrates excellent performance, and has broad application prospects in EMI shielding and thermal management of advanced microelectronic systems.

A self-healing polyurethane-based composite coating with high strength and anti-corrosion properties for metal protection

The self-healing ability of the organic coating is of pivotal importance to restore its protection functionality in case of a coating defect to ensure durable performance under demanding corrosive conditions. In this work, a novel NIR-triggered self-healing anti-corrosion coating is fabricated by cross-linking the PU prepolymer with furan modified CeO 2 via Diels-Alder (DA) bonds, which could effectively protect mild steel from corrosion upon damage. The synthesized nanoparticles and PU films were detailly characterized using a range of tools. The developed coating (PU-DA-d@CeNPs5) had excellent mechanical property (38.89 ± 0.52 MPa), notable adhesion performance (12 MPa), and also exhibited an impedance modulus at 0.01 Hz of 1.29 × 10 9 Ω cm 2 . The impedance modulus at 0.01 Hz can still exceed 10 7 Ω cm 2 after 100 days of continuous immersion. In addition, the photothermal conversion ability of dopamine enables the coating to self-heal rapidly within 20 s under near-infrared light. The mechanical and corrosion protection of the coating before and after self-healing were virtually unaffected. This work will provide an effective strategy for the preparation of anti-corrosion polyurethane coating with excellent mechanical performance and high self-healing efficiency. • Mechanically robust composite coating can be used as an excellent metal protection layer. • CeO 2 -PU composite coating shows ideal self-healing performance depended on DA dynamic bonds under NIR. • The corrosion protection of PU-DA-d@CeNPs5 after self-healing is almost the same as original (above 10 9 Ω cm 2 ).

Hydrophilic and hydrophobic films based on polyurethane cationomers containing TiO2 nanofiller

Polyurethane cationomers thin films containing (0–2 wt%) surface functionalized TiO2 as ecological water dispersions were obtained, and the structure of the cationomers have been confirmed using FTIR and NMR methods. Incorporation of the surface modified TiO2 nanoparticles caused considerable changes in the thermal, mechanical, and surface properties of the PU films. Importantly, films made with MDI isocyanate surface-modified TiO2 were hydrophobic and their free surface energy (FSE) was below 35 mJ/m2, while films containing unmodified TiO2 were hydrophilic with FSE above 48 mJ/m2. SEM observations exhibited uniform dispersion of nanoparticles in PU matrix. The activation energy of the glass transition process was calculated based on multifrequency TOPEM DSC data and the higher activation energy was found for composites with higher content of PU/TiO2 or PU/f-TiO2 due to the stronger hydrogen bonding between soft segment microdomains and hard segments after incorporation of PU/TiO2 or PU/f-TiO2. Good thermal and mechanical properties, which correspond to those of PU elastomers, are promising features for the application of the obtained cationomers as modern coating materials.

Flexible and resilient photothermal polyurethane film from polydopamine-coated phase change microcapsules

A major barrier to widespread use of solar energy remains: the need for storage to correct the mismatch between supply and demand. Herein, this paper prepared a flexible and resilient polyurethane film ( m -M n /PU) that could convert and store solar energy by compositing photothermal phase change microcapsules (microPCMs) coated with polydopamine (PDA) and waterborne polyurethane. The modified microPCMs (>225 J/g) were obtained via the surface deposition with PDA, and the m -M n /PU films displayed desirable photothermal storage efficiency from 49.1% to 66.8%. It was found that incorporation of PDA improved the elongation at break of 50-M n /PU films (>110 J/g) from 163% to 442% due to the favorable interaction of PDA-coated microPCMs with PU. The films also demonstrated the excellent thermal durability, photothermal cyclability and flexibility. The simple PDA deposition strategy could be adopted in making varieties of photothermal composites suitable for thermal energy management and solar energy collector system. • The microPCMs loading 1.2 wt% PDA had the photothermal property. • Photothermal PDA-coated microPCMs@PU films had the excellent flexibility. • The composite films had melting enthalpy over 110 J/g and thermal durability. • The composite films also had excellent photothermal cyclability.

Envelope radiation characteristics of stratospheric airship

To investigate the envelope radiation characteristic of stratospheric airship, three kinds of airship models with different dimensions (fineness ratio of 3, 4, 5) are selected. After establishing the thermal equilibrium equations of the selected models, the influence of the envelope radiation characteristic on the envelope and airship gas is first addressed to determine the optimal fineness ratio by considering the flight dynamics characteristics. Furthermore, the effects of envelope emissivity, envelope absorptivity, solar cells radiation characteristics, and typical envelope materials on the envelope radiation characteristics of airship are discussed in depth. The results show that: (1) With the assumption of same absorptivity and emissivity, the larger the fineness ratio of the airship, the smaller the diurnal temperature difference of the main helium gasbag, and the better the thermal characteristics of airship as well. When the envelope radiation characteristics vary, the temperature difference of main helium gasbag with a fineness ratio of 4 in one day is always less than 1 K, compared with the fineness ratio of 5. However, the temperature difference of main helium gasbag with a fineness ratio of 3 exceeds that with the fineness ratio of 5, and reaches its maximum of 6 K. Therefore, the fineness ratio of 4 is regarded as optimal by considering the floating constraints of low drag and high buoyancy. (2) In the case of higher long-wave emissivity and lower short-wave absorptivity of the envelope material and solar cells, the diurnal helium temperature difference is the smallest, and the thermal performance of the aerostat is better. (3) Among the five typical envelope materials, i.e., white Tedlar film, white PU film, silver-plated Teflon film, aluminized PET film, and white PVF film, the aluminized PET film is more conducive to controlling the helium temperature difference and reducing the volume change of gasbags. The aforementioned results can provide a theoretical basis for improving the thermal performance of stratospheric airships.

A Novel Design of Tri-Layer Membrane with Controlled Delivery of Paclitaxel and Anti-Biofilm Effect for Biliary Stent Applications.

Here, we developed a novel biliary stent coating material that is composed of tri-layer membrane with dual function of sustained release of paclitaxel (PTX) anticancer drug and antibacterial effect. The advantages of using electrospinning technique were considered for the even distribution of PTX and controlled release profile from the nanofiber mat. Furthermore, film cast method was utilized to fabricate AgNPs-immobilized PU film to direct the release towards the tumor site and suppress the biofilm formation. The in vitro antibacterial test conducted against Gram-positive (Staphylococcus aureus) and Gram-negative (Escherichia coli) bacteria species showed excellent antibacterial effect. The in vitro drug release study confirmed the sustained release of PTX from the tri-layer membrane and the release profile fitted first order with correlation coefficient of R2 = 0.98. Furthermore, the release mechanism was studied using Korsmeyer–Peppas model, revealing that the release mechanism follows Fickian diffusion. Based on the results, this novel tri-layer membrane shows curative potential in clinical development.

Development, In Vitro and In Vivo Evaluation of Racecadotril Orodispersible Films for Pediatric Use.

The present study endeavored to develop orodispersible films (ODFs) containing 30 mg racecadotril for pediatric use, which focuses on improving the compliance of pediatric patients and reducing risk of choking. The challenge of this study is to prepare high drug loading ODFs with successful mechanical and physicochemical properties. Compatibilities between drug and different polymers (hydroxypropyl methylcellulose, HPMC; polyvinyl alcohol, PVA; low-substituted hydroxypropyl cellulose, L-HPC; pullulan, PU) were investigated to select stable and safe film-forming polymers. Afterwards, the study explored the maximum amount of racecadotril incorporated into PVA films and PU films. Subsequently, disintegrant (Lycoat RS720, 4-10%, w/w) and plasticizers (glycerol, 2-6%, w/w) were investigated to reduce disintegration time of PVA films and enhance the flexibility of PU films, respectively. Formulation characteristics (appearance, tensile strength, percent elongation, disintegration time, drug content, weight, thickness, pH value, moisture content, moisture uptake, and Q5min) of prepared ODFs were examined to obtain the optimal compositions of racecadotril ODFs. Differential scanning calorimetry (DSC) study, powder X-ray diffraction (XRD) study, Fourier transform infrared (FTIR) study, comparative in vitro dissolution study, and pharmacokinetic study in Beagle dogs of optimized racecadotril ODFs were then conducted. Eventually, ODFs containing 50% racecadotril, 38% PVA, 7% Lycoat RS720, 2% sucralose, 2% apricot, and 1% titanium dioxide could achieve desirable mechanical properties, disintegrating within a few seconds and releasing more than 85% drug within 5min in four dissolution media. An in vivo study showed optimized racecadotril ODF and Hidrasec were bioequivalent in Beagle dogs. In summary, ODFs containing 30 mg racecadotril were successfully prepared by solvent casting method, and it was suitable for the administration to the pediatric patients.

Structure-Properties Relationship in Waterborne Poly(Urethane-Urea)s Synthesized with Dimethylolpropionic Acid (DMPA) Internal Emulsifier Added before, during and after Prepolymer Formation.

Dimethylolpropionic acid (DMPA) internal emulsifier has been added before, during and after prepolymer formation in the synthesis of waterborne poly(urethane-urea)s (PUDs) and their structure–properties relationships have been assessed. PUDs were characterized by pH, viscosity and particle size measurements, and the structure of the poly(urethane-urea) (PU) films was assessed by infra-red spectroscopy, differential scanning calorimetry, X-ray diffraction, thermal gravimetric analysis, plate–plate rheology and dynamic mechanical thermal analysis. The adhesion properties of the PUDs were measured by cross-hatch adhesion and T-peel test. The lowest pH value and the highest mean particle size were found in the PUD made by adding DMPA after prepolymer formation, all PUDs showed relatively ample mono-modal particle size distributions. The highest viscosity and noticeable shear thinning were obtained in the PUD made by adding DMPA during prepolymer formation. Depending on the stage of addition of DMPA, the length of the prepolymer varied and the PU films showed different degree of micro-phase separation. Because the shortest prepolymer was formed in the PU made with DMPA added before prepolymer, this PU film showed the lowest storage moduli and early melting indicating higher degree of micro-phase separation. The highest storage modulus, later melting, higher temperature and lower modulus at the cross between the storage and loss moduli corresponded to the PU made by adding DMPA after prepolymer formation, because the longer prepolymer produced during synthesis. The lowest thermal stability corresponded to the PU made by adding DMPA during prepolymer formation and the structures of all PU films were dominated by the soft domains, the main structural differences derived from the hard domains. Whereas DMPA-isophorone diisocyanate (IPDI) urethane and urea hard domains were created in the PU film made by adding DMPA during prepolymer formation, the other PU films showed DMPA-IPDI, polyester-IPDI and two different DMPA-IPDI-polyester hard domains. Finally, the adhesion properties of the PUDs and PU coatings were excellent and they were not influenced by the structural differences caused by adding DMPA in different stages of the synthesis.

Addition of small amounts of graphene oxide in the polyol during the synthesis of waterborne polyurethane urea adhesives for improving their adhesion properties

Mixtures of polyadipate of 1,4-butanediol polyol and different small amounts (0.01–0.10 wt%) of graphene oxide (GO) were added during the synthesis of waterborne polyurethane urea dispersions (PUDs) carried out with the acetone method. The addition of 0.02–0.04 wt% GO increased the T-peel strength of plasticized poly (vinyl chloride)/PUD/plasticized poly (vinyl chloride) joints whereas the addition of 0.05–0.10 wt% GO increased the single lap-shear strength of stainless steel/PUD/stainless steel joints. The improved adhesion of the PUDs containing GO was ascribed to the creation of covalent interactions between the surface groups on the GO surface and the NCO groups of the isocyanate during prepolymer formation, creating new urethane groups; during the phase inversion, the covalently bonded GO sheets were embedded between the polyurethane urea chains inside the PUD particles, this changed the degree of phase separation between the hard and the soft segments. When more than 0.04 wt% GO was added, some GO particles cannot be covalently bonded to the prepolymer during the PUD synthesis but they agglomerated and physically “trapped” between the polyurethane urea chains. As a consequence, the adhesion properties of the PU + GO films were different in the PU films containing 0.01–0.04 wt% GO and the ones containing 0.05–0.10 wt% GO.

Betel leaf-derived carbon nano-sphere/renewable resourced polyurethane coatings for high-performance applications

Present study focuses on the development of sustainable green-sourced carbon nano-sphere (CNSp) from Betel Leaf by thermal decomposition method for high-performance Polyurethane coating. The obtained carbon black was then functionalized with acid solution. FTIR analysis confirms the presence of carboxyl group. The graphitic domain present in the nano-sphere were found using XRD and Raman spectroscopy. TEM analysis clearly shows the mono-dispersed sized nano-spheres of about ~ 40 nm. The nano-sphere was further incorporated into castor oil based Polyurethane coatings. The nanoscale incorporation of the CNSp (0.2 and 0.5%) into the PU shows good increment in the resultant mechanical and thermo-mechanical properties of the polyurethane/carbon nano-sphere hybrid in comparison to the virgin PU film. The DMTA result shows an increase in the storage modulus from 3730 to 4454 MPa. Moreover, an accretion in the tensile strength was observed from 5.55 to 9.77 MPa Overall increments of 76.03% and good surface roughness observed by SEM analysis.

Shape memory thin films of polyurethane: Synthesis, characterization, and recovery behavior

AbstractPolyurethane thin films with inherent two phase segregated characters are exceptional candidates for the development of shape memory materials. However, controlling the phase behavior of such complex structures for decoding their recovery behavior still experiences its early stage of development. In this work, polyurethane thin films were synthesized based on two polyols, ester‐based polyols (ESP), and ether‐based polyols (ETP) together with diphenyl diisocyanate (MDI). The effects of ingredient ratio of PETP (ether‐based prepolymer)/PESP (ester‐based prepolymer) on the chemical structure and final properties of polyurethanes were studied by the Fourier‐transformed infrared spectroscopy (FTIR), the differential scanning calorimetry (DSC), the scanning electron microscopy (SEM), the dynamic mechanical thermal analysis (DMTA), a tensiometer, and the atomic force microscopy (AFM). The shape memory behaviors were explored by the thermomechanical cycles applied by a DMTA device in the controlled force mode. The PU films showed various properties compared with the bulk PU since they formed spherulitic textures with different structures. All the PU films except PU‐0 showed high shape recovery ca. 90% in the first cycle with a large glassy storage modulus in the range of 2,800–4,040MPa, and a recovery ratio enhanced by increasing the number of cycle to a maximum of 95%.

Layer‐by‐layer self‐assembly of collagen and chitosan biomolecules on polyurethane films

AbstractPolyurethane (PU) films used in wound dressing applications often have appropriate properties. Still, surface modification is necessary to increase the biocompatibility. In this research, the surface of the PU films was modified with collagen and chitosan biomolecules through layer by layer (LbL) self‐assembly process. The PU films were synthesized from castor oil and hexamethylene diisocyanate. Then, they were treated with low‐pressure nitrogen plasma to graft with poly(acrylic acid). Before performing the LbL process, the surfaces of the PU films were modified using three different reagents, including (A) NaOH solution, (B) EDC/NHS solution, or (C) hexamethylene diamine. Then, the collagen and chitosan deposited in three and five layers on the surface. The images of FESEM, confocal microscopy, and AFM showed that the best performance of the LbL deposition process was after the surface modification with hexamethylenediamine (HMDA). The MTT assay showed that the presence of these biomolecules had boosted the proliferation of fibroblast cells. Increasing the number of the deposited layer from three to five, decreased the cell viability and antibacterial activity of the films. The obtained results propose the modification with HMDA and the deposition of three layers of collagen and chitosan on the PU films to improve its biocompatibility.

Shape memory thin films of Polyurethane: Does graphene content affect the recovery behavior of Polyurethane nanocomposites?

AbstractThin nanocomposite films of polyurethane have received remarkable attention due to their shape memory properties. As most of the reports focus on the beneficial aspects of the presence of nanofillers such as graphene nanoplatelets (GNPs) introduced into shape memory polymers, some research results reveal the opposite trend. The polyether/polyester‐based polyurethane was synthesized through a condensation polymerization and the nanocomposite films containing 0.1, 0.25, 0.5, and 1 wt.% of GNPs were prepared by the solvent casting method. The Fourier transformed infrared (FTIR) spectroscopy was carried out to investigate the chemical structure of nanocomposite films. The properties of nanocomposite films were verified by the differential scanning calorimetry (DSC), X‐ray diffraction (XRD), atomic force microscopy (AFM), scanning electron microscopy (SEM), tensile test, and the dynamic mechanical analysis (DMA). The shape memory properties were studied through various thermomechanical cycles applied by the DMA apparatus. All the nanocomposite films showed larger glassy storage moduli compared with those of the neat PU films. The nanocomposite film containing 0.25 wt.% GNPs showed the highest shape recovery ratio (92.4%) since the net‐point effect of GNPs dominates its slipping effect. While for the other nanocomposite films the slippage effect overcomes the net‐point effect.

Synthesis of antibacterial polyurethane film and its properties

Abstract Polyurethane (PU) is a polymer widely used in the biomedical field with excellent mechanical properties and good biocompatibility. However, it usually exhibits poor antibacterial properties for practical applications. Efforts are needed to improve the antibacterial activities of PU films for broader application prospect and added application values. In the present work, two PU films, TDI-P(E-co-T) and TDI-N-100-P(E-co-T), were prepared. Silver nanoparticles (AgNPs) were composited into the TDI-N-100-P(E-co-T) film for better mechanical properties and antibacterial activities, and resultant PU/AgNPs composite film was systematically characterized and studied. The as-prepared PU/AgNPs composite film exhibits much better antibacterial properties than the traditional PU membrane, exhibiting broader application prospect.

An Inkjet-Printed Flexible Non-Enzymatic Lactate Sensor for Clinical Blood Plasma Test

In this letter, we demonstrate a fully inkjet-printed electrochemical lactate sensor. The sensor is inkjet-printed on a flexible substrate, Kapton film, where silver nanoparticles (Ag NPs) are printed as conductive electrodes. The working and reference electrodes of the sensor are Ag NPs/NiO NPs/Polyurethane (PU) and Ag/AgCl(s)/PU layers respectively. The inkjet-printed PU film can not only prevent the annihilation of the Ag NPs resulting from the dissolution of Ag and the formation of AgCl in the phosphate-buffered saline (PBS) but also stabilize the lactic acid measurements by maintaining a potential variant within 2% at different lactate concentrations. The as-printed sensor exhibits a linear sensitivity of 8.86nA/mM/mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> (R=99.6%) in the range from 0.6 to 2.2 mM. Clinical blood plasma testing results show that the trends of lactic acid change in patients measured by the sensor are the same as the ones measured using the existing detection method, colorimetric assays, in a tertiary university-affiliated hospital.

Plasma modification of heparinised CNT/PU nanocomposite and measuring of mechanical, calcification and platelet adhesion properties for application in heart valve

ABSTRACT In this study, the calcification and platelet adhesion resistance property of plasma-treated polyurethane/heparinised carbon nano tube (PU/HCNT) nanocomposite thin films as a candidate polymer for polymeric heart valve was investigated. The PU and HCNTs nanocomposite films (PU/HCNT) were prepared using the solvent casting technique. CNTs were heparinised to surpass the dispersal and calcification resistance of CNTs in the PU matrix. Dispersal of CNTs in the matrix of produced films was analysed with (TEM), and HCNTs were observed well distributed in the polymer matrix. Greater storage modulus and better calcification resistance were detected for the nanocomposite. DMTA used for determining nanocomposite properties, which showed that the modulus increased as modified CNTs added to the matrix. The composite films were exposed to oxygen plasma treatment. The modified surface was characterised using ATR-FTIR, SEM, EDXA, and water drop contact angle measurements. The results indicated that the treated PU/HCNT surface was more hydrophilic. Increased surface roughness for modified PU/HCNT surface observed in AFM images. In-vitro calcification test verified reduced calcification for the modified PU/HCNT surface. No cytotoxicity was observed for the modified polymeric films using L929 fibroblast cells. The platelet adhesion test showed that the modified films are more blood compatible than unmodified.

Preparation of UV-Curable Low Surface Energy Polyurethane Acrylate/Fluorinated Siloxane Resin Hybrid Coating with Enhanced Surface and Abrasion Resistance Properties.

Low surface energy coatings have gained considerable attention due to their superior surface hydrophobic properties. However, their abrasion resistance and sustainability of surface hydrophobicity are still not very satisfactory and need to be improved. In this work, a series of utraviolet (UV)-curable fluorosiloxane copolymers were synthesized and used as reactive additives to prepare polyurethane acrylate coatings with low surface energy. The effect of the addition of the fluorinated graft copolymers on the mechanical durability and surface hydrophobicity of the UV-cured hybrid films during the friction-annealing treatment cycles was investigated. The results show that introducing fluorosiloxane additives can greatly enhance surface hydrophobicity of the hybrid film. With addition of 2 wt.% fluorosiloxane copolymers, the water contact angle (WCA) value of the hybrid film was almost tripled compared to that of the pristine PU film, increasing from 58° to 144°. The hybrid film also showed enhanced abrasion resistance and could withstand up to about 60 times of friction under a pressure of 20 kPa. The microstructure formed in the annealed film was found to contribute much to achieve better surface hydrophobicity. The polyurethane acrylate/fluorinated siloxane resin hybrid film prepared in this study exhibits excellent potential for applications in the low surface energy field.

Preparation of gallic acid modified waterborne polyurethane made from bio-based polyol

WPU was prepared by a simple and bio-based method using poly(1,3-propylene glycol-adipic acid) (PPA) and isophorone diisocyanate (IPDI) as raw materials. Intriguingly, PPA can be synthesized using 1,3-propanediol which was extracted from plant stalk. Then a non-toxic, environmental-friendly gallic acid modified bio-based waterborne polyurethane (GWPU) was successfully prepared utilizing the prepolymer method with gallic acid (GA) was as a modifier. The structures, morphologies and thermostability of GWPU were confirmed by FTIR, TEM, TG, DSC and AFM. Furthermore. Its mechanical properties and water resistance were evaluated as well. The results demonstrated that self-prepared PPA has no influence on the properties of polyurethane. However, when the content of GA was increased from 0% to 3.3%, the tensile strength of GWPU film increased by 155.3% compared with that of unmodified PU film, the elongation at break decreased by 86%, and the decomposition temperature of the film increased by 23.8 °C, the surface roughness decreased by 41.0%. In addition, through the crosslinking of GA, the water resistance of GWPU is improved.

Tunable Fabrication of Conductive Ti3C2Tx MXenes via Inflating a Polyurethane Balloon for Acute Force Sensing.

Conductive microwrinkles present a superior performance in ultrasensitive sensing, smart controlling, as well as energy conservation because of their unique structures. These wrinkles are usually prepared by the deposition of a thin conductive stiff layer on a soft substrate under a certain strain. However, traditional conductive materials may encounter some deficiencies, such as fragility or poor dispersity, in any solvent. To promote the applicability of conductive microwrinkles, here, we adopt a new two-dimensional nanomaterial Ti3C2Tx MXene as the conductive stiff layer to construct the microwrinkles. By combining the spraying and inflating techniques, the hierarchical complex and delicate Ti3C2Tx-polyurethane (Ti3C2Tx-PU) microwrinkles have become facilely available. The characteristic wavelength and amplitude of the microwrinkles could be easily adjusted by altering the inflating height of the PU film or the spraying volume of the Ti3C2Tx solution. Because the as-prepared Ti3C2Tx wrinkles could sensitively generate deformation inducing a resistance change under a force, these structures are also assembled to detect the applied force. The Ti3C2Tx force sensors showed quick response to a tiny force and stable reliability over hundreds of cycles, which hold a promising potential to monitor or employ the microforce.