The aim of this study is to analyse a use of psychopharmacs in combat veterans suffering from PTSD in two Croatian regions, Dalmatia and Slavonia. A great number of new psychopharmacs have changed the pharmacological approach to the treatment of many psychiatric disorders. Each of the new psychopharmacs is spreading its indication area. The study will be conducted as a cross-sectional study on the out-treated patients with diagnosed PTSD, treated at the Psychiatric Clinic in Split and Psychiatric Clinic in Osijek for at least six years. The study will include 400 patients with diagnosed chronic Posttraumatic stress disorder. Analysing the therapy authors noticed usage of broad spectrum of psychopharmacs (antidepressants, anxiolitics, antipsychotics, mood stabilisators). According to a clinical manifestation in patients with chronic PTSD different combinations of psychopharmacs were used in different doses. A trend of usage of new generations of antidepressants and a new generation of antipsychotics is evident.