Percutaneous treatment of native coronary and saphenous vein graft aorto-ostial (A-O) stenosis has been associated with lower procedural success rates of 70% to 97%, more frequent in-hospital complications of 5% to 12%, and a greater likelihood of late restenosis of 28% to 52% when compared with the treatment of nonostial lesions. 1 Eigler N.L. Weinstock B. Douglas Jr, J.S. Goldenberg T. Hartzler G. Holmes D. Leon M. Margolis J. Nobuyoshi M. O’Neill W. Excimer laser coronary angioplasty of aorto-ostial stenoses. Results of the excimer laser coronary angioplasty (ELCA) registry in the first 200 patients. Circulation. 1993; 88: 2049-2057 Crossref PubMed Scopus (56) Google Scholar , 2 Sabri M.N. Cowley M.J. DiSciascio G. DeBottis D. Kelly K. Goudreau E. Vetrovec G.W. Immediate results of interventional devices for coronary ostial narrowing with angina pectoris. Am J Cardiol. 1994; 73: 122-125 Abstract Full Text PDF PubMed Scopus (21) Google Scholar , 3 Stephan W.J. Bates E.R. Garratt K.N. Hinohara T. Muller D.W. Directional atherectomy of coronary and saphenous vein graft ostial stenoses. Am J Cardiol. 1995; 75: 1015-1018 Abstract Full Text PDF PubMed Scopus (12) Google Scholar , 4 Hoffmann R. Mintz G.S. Mehran R. Pichard A.D. Kent K.M. Satler L.F. Popma J.J. Wu H. Leon M.B. Intravascular ultrasound predictors of angiographic restenosis in lesions treated with Palmaz-Schatz stents. J Am Coll Cardiol. 1998; 31: 43-49 Abstract Full Text Full Text PDF PubMed Scopus (272) Google Scholar , 5 Heidland U.E. Heintzen M.P. Michel C.J. Strauer B.E. Risk factors for the development of restenosis following stent implantation of venous bypass grafts. Heart. 2001; 85: 312-317 Crossref PubMed Scopus (21) Google Scholar , 6 Rocha-Singh K. Morris N. Wong S.C. Schatz R.A. Teirstein P.S. Coronary stenting for treatment of ostial stenoses of native coronary arteries or aortocoronary saphenous venous grafts. Am J Cardiol. 1995; 75: 26-29 Abstract Full Text PDF PubMed Scopus (77) Google Scholar , 7 Jain S.P. Liu M.W. Dean L.S. Babu R. Goods C.M. Yadav J.S. Al-Shaibi K.F. Mathur A. Iyer S.S. Parks J.M. Baxley W.A. Roubin G.S. Comparison of balloon angioplasty versus debulking devices versus stenting in right coronary ostial lesions. Am J Cardiol. 1997; 79: 1334-1338 Abstract Full Text PDF PubMed Scopus (40) Google Scholar Stents, despite their proved benefit in other indications, do not substantially reduce the incidence of restenosis in A-O lesions. 5 Heidland U.E. Heintzen M.P. Michel C.J. Strauer B.E. Risk factors for the development of restenosis following stent implantation of venous bypass grafts. Heart. 2001; 85: 312-317 Crossref PubMed Scopus (21) Google Scholar , 6 Rocha-Singh K. Morris N. Wong S.C. Schatz R.A. Teirstein P.S. Coronary stenting for treatment of ostial stenoses of native coronary arteries or aortocoronary saphenous venous grafts. Am J Cardiol. 1995; 75: 26-29 Abstract Full Text PDF PubMed Scopus (77) Google Scholar , 8 Zampieri P. Colombo A. Almagor Y. Maiello L. Finci L. Results of coronary stenting of ostial lesions. Am J Cardiol. 1994; 73: 901-903 Abstract Full Text PDF PubMed Scopus (99) Google Scholar Balloon expandable stents covered by a polytetrafluoroethylene (PTFE) membrane have been used for the treatment of de novo lesions in saphenous vein grafts with favorable results. 9 Baldus S. Koster R. Elsner M. Walter D.H. Arnold R. Auch-Schwelk W. Berger J. Rau M. Meinertz T. Zeiher A.M. Hamm C.W. Treatment of aortocoronary vein graft lesions with membrane-covered stents a multicenter surveillance trial. Circulation. 2000; 102: 2024-2027 Crossref PubMed Scopus (74) Google Scholar , 10 Briguori C. De Gregorio J. Nishida T. Adamian M. Albiero R. Tucci G. Di Mario C. Colombo A. Polytetrafluoroethylene-covered stent for the treatment of narrowings in aorticocoronary saphenous vein grafts. Am J Cardiol. 2000; 86: 343-346 Abstract Full Text Full Text PDF PubMed Scopus (38) Google Scholar , 11 Baldus S. Koster R. Reimers J. Kahler J. Meinertz T. Hamm C.W. Membrane-covered stents a new treatment strategy for saphenous vein graft lesions. Catheter Cardiovasc Interv. 2001; 53: 1-4 Crossref PubMed Scopus (20) Google Scholar The membrane coverage yields a rationale to use the device in A-O lesions, to prevent proliferation through the stent struts from the aortic wall, and possibly decrease the restenosis rate. We report the angiographic and immediate and late long-term clinical results of the first published cohort of patients that received PTFE-covered stents for the treatment of A-O lesions.