You have accessJournal of UrologyProstate Cancer: Localized VIII1 Apr 2015MP78-20 OPEN RADICAL PROSTATECTOMY IN TRANSPLANT PATIENTS. Burkhard Beyer, Thomas Steuber, Philipp Schriefer, Uwe Michl, Hans Heinzer, Thorsten Schlomm, Hartwig Huland, Markus Graefen, and Derya Tilki Burkhard BeyerBurkhard Beyer More articles by this author , Thomas SteuberThomas Steuber More articles by this author , Philipp SchrieferPhilipp Schriefer More articles by this author , Uwe MichlUwe Michl More articles by this author , Hans HeinzerHans Heinzer More articles by this author , Thorsten SchlommThorsten Schlomm More articles by this author , Hartwig HulandHartwig Huland More articles by this author , Markus GraefenMarkus Graefen More articles by this author , and Derya TilkiDerya Tilki More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2015.02.2919AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Oncologic surgery in immunosuppressed patients with solid organ transplantation (Tx) is challenging. These patients are thought to have higher postoperative morbidity and an increased rate of tumour progression. Aim of the study was a retrospective analysis of perioperative outcome and tumour-specific morbidity and mortality in Tx patients following radical prostatectomy (RP). METHODS Between 1996 and 2014 RP was performed on 30 patients diagnosed with PCa following Tx (kidney Tx: n=20, heart Tx: n=5, liver Tx: n=5) at our institution. The median follow-up was 45 months. Postoperative complications were assessed with the Clavien-Dindo Classification. RESULTS Median age at PCa diagnosis was 64 years (51-73). Median PSA at diagnosis was 5.3 ng/ml (1.0-250.0). Median intraoperative blood loss was 600 ml (100 ml – 1600 ml) at a median operating time of 180 min (120 – 285 min). Surgery in kidney tx patients was technically feasible. Major complications occured in 3 patients (urethral injury, lymphocele, hematoma). Histological evaluation revealed n=18 ≤pT2 tumours (60.0%), n=7 pT3a tumours (23.3%) and n=5 ≥pT3b tumours (16.7%). Continence rate at 12 months was 70.0% (n=21) defined as no pad use and 90.0% (n=27) for ≤ 2 pads / 24h. This rate is lower than in other series due to comorbidities of Tx patients. After a median follow-up of 45 months BCR-free survival was 70.0%. In recurrent patients there was no evidence of metastasis or cancer-specific death. Overall survival was 86.6%. CONCLUSIONS The complication rate in patients with solid organ transplantation after radical prostatectomy was low. Histopathological evaluation revealed disease characteristics of current RP series. Immunosuppressive therapy therefore does not seem to lead to an increased rate of tumour progression. © 2015 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 193Issue 4SApril 2015Page: e1010 Advertisement Copyright & Permissions© 2015 by American Urological Association Education and Research, Inc.MetricsAuthor Information Burkhard Beyer More articles by this author Thomas Steuber More articles by this author Philipp Schriefer More articles by this author Uwe Michl More articles by this author Hans Heinzer More articles by this author Thorsten Schlomm More articles by this author Hartwig Huland More articles by this author Markus Graefen More articles by this author Derya Tilki More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...