Background. The process of psychotherapy of alcohol-addicted persons becomes effective through understanding the relationship between self-activation motives, the state of self-regulation and their social functioning. Purpose: To study the relationship between the assessment of self-activation, volitional self-regulation and the types of interpersonal relationships in alcohol-dependent persons in order to determine therapeutic «targets» for a targeted impact on dependent constructs in the process of psychotherapy. Material and methods. The study was conducted on the basis of the medical and labor dispensary (LTP) No.5 of the Ministry of Internal Affairs of the Republic of Belarus. A total of 250 men aged 24 to 60 years were examined. Group I included persons with alcohol dependence syndrome, who while in the LTP setting, underwent psychotherapy for persons with alcohol dependence syndrome (150). Group II consisted of persons with alcohol dependence syndrome, who while in the LTP setting, participated in the standard program of medical and social readaptation (100). The following psychodiagnostic methods were used: test questionnaire «Research of volitional self-regulation»; BIS/BAS questionnaire; the technique «Diagnostics of interpersonal relations». Results. The results of assessing the type of interpersonal relationships, volitional self-regulation and sensitivity to positive and negative stimuli did not reveal statistically significant differences between the groups (p>0.05). We identified weak positive relationships in people of group I between «Perseverance» on the BAS scale and the type of relationship «Selfish», «Aggressive», «Suspicious», «Dependent» (p<0.01); between «Pleasure seeking» on the BAS scale and «Authoritarian» (p<0.01), between «Pleasure seeking» on the BAS scale and «Aggressive», «Suspicious», «Dependent» (p<0.01); between BIS and «Suspicious», «Subordinate», «Dependent», «Friendly», «Altruistic» (p<0.05). Weak negative relationships were identified in people of groups I and II between the BIS scale and the scale of volitional self-regulation «Persistence», «General level of volitional self-regulation» (p<0.05). We also identified weak negative relationships in people of group I between the «Self-control» scale and BAS «Persistence», BAS «Pleasure seeking», BAS «Reactivity» (p<0.01); between BAS «Persistence» and BAS «Search for pleasure» and the scale «General level of volitional self-regulation» (p<0.01). Conclusion. The obtained data of relationships made it possible to take into account the dual nature of the selfactivation system and include an intermittent sequence in the process of psychotherapy: the importance of emotional support experience (BAS), leveling and reshaping of negative experience (BIS), reassessment of the subjective significance of one's own personality with the activation of awareness and constructive choice of effective sobriety tools (BAS), the development of a system to counter dependent stimuli and challenges (BIS), the integration of the value of sober thinking into the life system (BAS).