Summaryo1.Neuroleptic drugs have specific pharmacologic effects (pharmacologic profile) when administered in adequate dosage.2.These effects are specific for their central nervous system activity, but are gross, global and nonspecific as to therapeutic outcome.3.Patients differ greatly as to therapeutic result, despite the presence of the typical pharmacologic effects.4.The therapeutic result depends on the manner in which the patient integrates the pharmacological profile of the drug concerned into his total situation.5.Our technic for selection and use of the neuroleptic drugs in a psychoanalytically oriented psychotherapeutic context has been described, both for in-patients and out-patients in general hospital settings, and for the rare cases in which some medication is needed in private office psychoanalytic psychotherapy.6.The modalities of action of the drugs in the treatment of schizophrenia, borderline, and neurotic patients have been described in terms of the actual setting. Neuroleptic drugs have specific pharmacologic effects (pharmacologic profile) when administered in adequate dosage. These effects are specific for their central nervous system activity, but are gross, global and nonspecific as to therapeutic outcome. Patients differ greatly as to therapeutic result, despite the presence of the typical pharmacologic effects. The therapeutic result depends on the manner in which the patient integrates the pharmacological profile of the drug concerned into his total situation. Our technic for selection and use of the neuroleptic drugs in a psychoanalytically oriented psychotherapeutic context has been described, both for in-patients and out-patients in general hospital settings, and for the rare cases in which some medication is needed in private office psychoanalytic psychotherapy. The modalities of action of the drugs in the treatment of schizophrenia, borderline, and neurotic patients have been described in terms of the actual setting.