The labor situation is considered essential for social follow-up; however, the contradiction between its importance and the psychic changes it can cause to workers should be considered. To check the presence of burnout syndrome in Primary Health Care workers in a municipality in the interior of the state of São Paulo and to check the association with the sociodemographic and labor data of these workers. Exploratory cross-sectional and quantitative study with 74 workers and developed from July to October 2020. Data were collected using an instrument for sociodemographic and labor characterization and for measurement of the syndrome, the Oldenburg Burnout Inventory already validated in Brazil. Descriptive statistics, frequency, percentage, measures of central tendency and dispersion were used; Fisher's exact test was applied to check the association between the studied variables and the burnout syndrome, considering the significance level of p < 0.05. The obtained data were discussed using the existing literature. Among the participants, 20.3% had no changes, 18.9% showed distance, 16.2% had exhaustion, and 44.6% had burnout syndrome. There was statistical significance for the variable unit of work (p < 0.014). The importance of studying labor mental health in Primary Health Care is because of the constant exposure of workers to psychosocial risk situations in social settings and their instabilities. Knowledge of the conditions allows for intervention actions in the environments and makes it possible to face the problems.
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