Psychophysical Tasks Research Articles

Neuroscience needs behavior: inferring psychophysical strategy trial by trial

Tools quantifying dynamic behavior are important to understand brain function. In this issue of Neuron, Roy etal. (2021) extended the available repertoire with PsyTrack, which tracks, trial by trial, how subjects performing psychophysical tasks adjust the way they weigh stimuli and task covariates or change their biases.

Magnocellular and Parvocellular Mediated Luminance Contrast Discrimination in Severe Alcohol Use Disorder

Severe alcohol use disorder (SAUD) is associated with widespread cognitive impairments, including low-level visual processing deficits that persist after prolonged abstinence. However, the extent and characteristics of these visual deficits remain largely undetermined, impeding the identification of their underlying mechanisms and influence on higher-order processing. In particular, little work has been conducted to assess the integrity of the magnocellular (MC) and parvocellular (PC) visual pathways, namely the 2 main visual streams that convey information from the retina up to striate, extrastriate, and dorsal/ventral cerebral regions. We investigated achromatic luminance contrast processing mediated by inferred MC and PC pathways in 33 patients with SAUD and 32 matched healthy controls using 2 psychophysical pedestal contrast discrimination tasks that promote responses of inferred MC or PC pathways. We relied on a staircase procedure to assess participants' ability to detect small changes in luminance within an array of 4 gray squares that were either continuously presented (steady pedestal, MC-biased) or briefly flashed (pulsed pedestal, PC-biased). We replicated the expected pattern of MC and PC contrast responses in healthy controls. We found preserved dissociation of MC and PC contrast signatures in SAUD but higher MC-mediated mean contrast discrimination thresholds combined with a steeper PC-mediated contrast discrimination slope compared with healthy controls. These findings indicate altered MC-mediated contrast sensitivity and PC-mediated contrast gain, confirming the presence of early sensory disturbances in individuals with SAUD. Such low-level deficits, while usually overlooked, might influence higher-order abilities (e.g., memory, executive functions) in SAUD by disturbing the "coarse-to-fine" tuning of the visual system, which relies on the distinct functional properties of MC and PC pathways and ensures proper and efficient monitoring of the environment.

Inferior Auditory Time Perception in Children With Motor Difficulties.

Accurate time perception is crucial for hearing (speech, music) and action (walking, catching). Motor brain regions are recruited during auditory time perception. Therefore, the hypothesis was tested that children (age 6-7) at risk for developmental coordination disorder (rDCD), a neurodevelopmental disorder involving motor difficulties, would show nonmotor auditory time perception deficits. Psychophysical tasks confirmed that children with rDCD have poorer duration and rhythm perception than typically developing children (N=47, d=0.95-1.01). Electroencephalography showed delayed mismatch negativity or P3a event-related potential latency in response to duration or rhythm deviants, reflecting inefficient brain processing (N=54, d=0.71-0.95). These findings are among the first to characterize perceptual timing deficits in DCD, suggesting important theoretical and clinical implications.

Multifocal acceptance score to evaluate vision: MAS-2EV

We present a new metric (Multifocal Acceptance Score, MAS-2EV) to evaluate vision with presbyopic corrections. The MAS-2EV is based on a set of images representing natural visual scenes at day and night conditions projected in far and near displays, and a near stereo target. Subjects view and score the images through different binocular corrections (monofocal corrections at far; bifocal corrections; monovision and modified monovision) administered with soft contact lenses (in cyclopleged young subjects) or with a binocular simultaneous vision simulator (in presbyopic and cyclopleged young subjects). MAS-2EV scores are visually represented in the form of polygons, and quantified using different metrics: overall visual quality, visual degradation at far, visual benefit at near, near stereo benefit, visual imbalance near-far, overall visual imbalance and a combined overall performance metric. We have found that the MAS-2EV has sufficient repeatability and sensitivity to allow differentiation across corrections with only two repetitions, and the duration of the psychophysical task (3 min for subject/condition/correction) makes it useable in the clinic. We found that in most subjects binocular bifocal corrections produce the lowest visual imbalance, and the highest near stereo benefit. 46.67% of the subjects ranked binocular bifocal corrections first, and 46.67% of the subjects ranked monovision first. MAS-2EV, particularly in combination with visual simulators, can be applied to select prospective presbyopic corrections in patients prior to contact lens fitting or intraocular lens implantation.

Сognitive Style Differences in Detection and Discrimination of Sensory Signals

The purpose of the study was to test individual differences in sensory sensitivity while performing signal detection and signal discrimination tasks. A total of 98 subjects performed two cognitive style tests on flexibility and rigidity of cognitive control, and focusing and scanning control, as well as two psychophysical tasks on visual signal detection (“yes/no” method) and loudness discrimination (“same/different”), each including two difficulty levels. Task type and difficulty level were considered as stimulation factors, and cognitive styles were considered as individual differences factors. The effects of both cognitive styles along with the effect of their interaction were revealed. ‘Flexible’ subjects and ‘scanners’ showed higher sensitivity in signal detection compared to ‘rigid’ subjects and ‘focusers’, respectively. Whereas no between-group differences were found in the accuracy of signal discrimination. Thus, we revealed individual differences in sensitivity, driven by cognitive style characteristics on the one hand, and task type on the other.

Awareness and confidence in perceptual decision-making

Perceptual decision-making employs a range of higher order metacognitive processes. Two of the most important of these are perceptual awareness; or the clarity with which one reports seeing a perceptual stimulus, and response confidence; or the certainty one has about the correctness of one's own perceptual categorizations. We used a novel false feedback paradigm to investigate the relationships between these two processes. We asked people to perform a standard psychophysical detection task. We used feedback to selectively intervene either on our participants’ trust in their own perceptual awareness of the stimulus, or on their confidence in their own responses. We measured the effects of these interventions on response accuracy; on reports of perceptual awareness; and on response confidence. We found that by undermining people's trust in their awareness of the sensory stimulus, we could reliably reduce their accuracy on the task. We suggest that the reason this occurred is that people came to rely less on evidence from their senses when making perceptual decisions. We conclude by suggesting that there is a not a one-to-one mapping between content in conscious experience and how that content is used in perceptual decision making, and that one's perception of the reliability of content also plays a role. Statement of SignificanceThis paper explores how different kinds of metacognitive state are related to one another and to perceptual decision making. Our focus is on the states of metacognitive confidence and perceptual awareness. We examine how an intervention on the reliability of these states influences performance in a perceptual detection task. We also examine how the intervention influences reports of the states themselves. The intervention we use is false feedback. For one group of participants, we tell them their perceptual judgement is wrong whenever they report they are uncertain in their choice (confidence intervention). For another group, we tell them their judgement is wrong whenever they report that their experience of the stimulus is unclear (awareness intervention). We find that both interventions reduce the accuracy of people's judgements, but that the awareness intervention is more effective. Also, we find that only the awareness intervention reduces reports of both metacognitive confidence in the response, and awareness of the stimuli. The confidence intervention does not influence either metacognitive state. These results suggest that we should understand confidence and awareness as separate higher level cognitive states, and that we should understand awareness as having a stronger causal role than confidence in perception and performance.

The Contribution of Frequency Discrimination Ability to Auditory Temporal Patterning Tests in Children.

Purpose The Pitch Patterns Test (PPT) and the Duration Patterns Test (DPT) are clinical auditory processing tests that evaluate temporal patterning skills based on pitch (PPT) or duration (DPT) aspects of sound. Although temporal patterning tests are categorized under the temporal processing domain, successful performance on the PPT also relies on accurate pitch discrimination. However, the relationship between pitch discrimination ability and temporal patterning skills has not been thoroughly evaluated. This study examined the contribution of pitch discrimination ability to performance on temporal patterning in children through the use of a pitch discrimination task and the PPT. The DPT was also given as a control measure to assess temporal patterning with no pitch component. Method Thirty-two typically developing elementary school-age children (6;11-11;3 [years;months]) with normal hearing were given a series of three counterbalanced tasks: an adaptive psychophysical pitch discrimination task (difference limen for frequency [DLF]), the PPT, and the DPT. Results Correlational analysis revealed moderate correlations between DLF and PPT scores. After accounting for age, results of a linear regression analysis suggested that pitch discrimination accounts for a significant amount of variance in performance on the PPT. No significant correlation was found between DLF and DPT scores, supporting the hypothesis that the pitch task had no significant temporal patterning component contributing to the overall score. Discussion These findings indicate that pitch discrimination contributes significantly to performance on the PPT, but not the DPT, in a typically developing pediatric population. This is an important clinical consideration in both assessment and utilization of targeted therapy techniques for different clinical populations.

Pre-stimulus alpha predicts inattentional blindness.

Pre- and post-stimulus oscillatory activity between 8 and 12 hertz, referred to as the alpha-band, correlates with conscious visual awareness of stimuli across a variety of psychophysical tasks. Within an EEG-adapted inattentional blindness task, the current study sought to examine whether this relationship holds for conscious awareness of stimuli under conditions of inattentional blindness. Noticing rates of the task-irrelevant unexpected stimulus were correlated with a significant decrease in alpha power over bilateral parietal-occipital areas during the pre-stimulus interval, and a significant decrease in alpha power over parietal-occipital regions in the right hemisphere during the post-stimulus interval. Findings are taken to imply alpha-band neural activity represents a valid correlate of consciousness that is not confounded by task relevancy or the need for report.

Unimpaired perception of relative depth from perspective cues in strabismus.

Strabismus is a relatively common ophthalmological condition where the coordination of eye muscles to binocularly fixate a single point in space is impaired. This leads to deficits in vision and particularly in three-dimensional (3D) space perception. The exact nature of the deficits in 3D perception is poorly understood as much of understanding has relied on anecdotal reports or conjecture. Here, we investigated, for the first time, the perception of relative depth comparing strabismic and typically developed binocular observers. Specifically, we assessed the susceptibility to the depth cue of perspective convergence as well as the capacity to use this cue to make accurate judgements of relative depth. Susceptibility was measured by examining a 3D bias in making two-dimensional (2D) interval equidistance judgements and accuracy was measured by examining 3D interval equidistance judgements. We tested both monocular and binocular viewing of images of perspective scenes under two different psychophysical methods: two-alternative forced-choice (2AFC) and the method of adjustment. The biasing effect of perspective information on the 2D judgements (3D cue susceptibility) was highly significant and comparable for both subject groups in both the psychophysical tasks (all ps < 0.001) with no statistically significant difference found between the two groups. Both groups showed an underestimation in the 3D task with no significant difference between the group's judgements in the 2AFC task, but a small statistically significant difference (ratio difference of approx. 10%, p = 0.016) in the method of adjustment task. A small but significant effect of viewing condition (monocular versus binocular) was revealed only in the non-strabismic group (ratio difference of approx. 6%, p = 0.002). Our results show that both the automatic susceptibility to, and accuracy in the use of, the perspective convergence cue in strabismus is largely comparable to that found in typically developed binocular vision, and have implications on the nature of the encoding of depth in the human visual system.

Underwater hearing and communication in the endangered Hawaiian monk seal Neomonachus schauinslandi

Hawaiian monk seals are among the most endangered marine mammals and the most basal of the phocid seals. The auditory biology of monk seals is compelling from behavioral, evolutionary, and conservation perspectives, but we presently lack substantive bioacoustic information for this species, with no formal descriptions of underwater vocalizations and limited data concerning hearing. These seals have been isolated for more than 10 million yr and have auditory structures differing from those of related species. Additionally, unlike other aquatically mating phocids, monk seals breed asynchronously and are not known to produce social calls in water. To address existing knowledge gaps, we trained a mature male Hawaiian monk seal to perform a psychophysical task while submerged. Detection thresholds were measured for narrowband sounds across the frequency range of hearing. We also conducted a year-round characterization of the seal’s spontaneous underwater vocalizations. This individual demonstrated best hearing between 0.2 and 33 kHz, with a lower high-frequency roll-off than that of related species. Hearing at all frequencies was less sensitive than in other true seals. Despite the absence of conspecifics, the seal regularly produced 6 different underwater calls with energy below 1 kHz. Calling patterns reflected a period of annual reproductive activity lasting about 6 mo, coincident with elevated testosterone levels. This study presents the first examination of underwater vocalizations in Hawaiian monk seals, provides insight into the auditory abilities of this species and the evolution of underwater hearing among phocids, and enables improved assessments of noise effects on these vulnerable seals.

How the known reference weakens the visual oblique effect: a Bayesian account of cognitive improvement by cue influence

This paper investigates the influence of a known cue on the oblique effect in orientation identification and explains how subjects integrate cue information to identify target orientations. We design the psychophysical task in which subjects estimate target orientations in the presence of a known oriented reference line. For comparison the control experiments without the reference are conducted. Under Bayesian inference framework, a cue integration model is proposed to explain the perceptual improvement in the presence of the reference. The maximum likelihood estimates of the parameters of our model are obtained. In the presence of the reference, the variability and biases of identification are significantly reduced and the oblique effect of orientation identification is obviously weakened. Moreover, the identification of orientation in the vicinity of the reference line is consistently biased away from the reference line (i.e., reference repulsion). Comparing the predictions of the model with the experimental results, the Bayesian Least Squares estimator under the Variable-Precision encoding (BLS_VP) provides a better description of the experimental outcomes and captures the trade-off relationship of bias and precision of identification. Our results provide a useful step toward a better understanding of human visual perception in context of the known cues.

Wrist proprioceptive acuity is linked to fine motor function in children undergoing piano training.

Playing the piano involves rapid and precise upper limb movements, which require seamless integration of the proprioceptive and motor systems. In this study, we comprehensively assessed active and passive proprioception and different domains of motor function in young pianists, aiming to understand how their proprioceptive and motor functions are improved. Fifty-seven participants, including seventeen 11- to 12-yr-old (young) pianists, 20 children, and 20 adults, were included. The children in the pianist group had received piano training for 6 yr, whereas the children and adults in the control groups had no previous experience with instrumental training. All participants performed a psychophysical discrimination threshold hunting task and an ipsilateral joint position reproduction task, both of which measured the position sense acuity of the wrist. Their motor function was evaluated by the Movement Assessment Battery for Children, 2nd edition. The results revealed that the young pianists showed a significantly lower position sense discrimination threshold (31%) and fewer joint position reproduction errors (49%) than the nontrained children. Second, a higher level of manual dexterity, but not of ball skills or balance, was found in the young pianist group. Third, a higher proprioceptive acuity (i.e., decreased position sense discrimination threshold) significantly correlated with higher manual dexterity. This study documents that a high wrist position sense is a common characteristic among young pianists. The increased upper limb position sense acuity is correlated with better manual dexterity, suggesting that piano practice may benefit untrained fine motor skills in children.NEW & NOTEWORTHY We document that improved proprioceptive acuity is a common feature in young pianists. This proprioceptive improvement is associated with both proprioceptive processing and proprioceptive-motor integration. Higher wrist proprioceptive acuity in young pianists is linked to enhanced manual dexterity, which suggests that intensive piano training may improve untrained fine motor skills.

Disrupted Eye Gaze Perception as a Biobehavioral Marker of Social Dysfunction: An RDoC Investigation.

Social dysfunction is an intractable problem in a wide spectrum of psychiatric illnesses, undermining patients' capacities for employment, independent living, and maintaining meaningful relationships. Identifying common markers of social impairment across disorders and understanding their mechanisms are prerequisites to developing targeted neurobiological treatments that can be applied productively across diagnoses and illness stages to improve functional outcome. This project focuses on eye gaze perception, the ability to accurately and efficiently discriminate others' gaze direction, as a potential biomarker of social functioning that cuts across psychiatric diagnoses. This premise builds on both the monkey and human literatures showing gaze perception as a basic building block supporting higher-level social communication and social development, and reports of abnormal gaze perception in multiple psychiatric conditions accompanied by prominent social dysfunction (e.g., psychosis-spectrum disorders, autism-spectrum disorders, social phobia). A large sample (n = 225) of adolescent and young adult (age 14-30) psychiatric patients (regardless of diagnosis) with various degrees of impaired social functioning, and demographically-matched healthy controls (n = 75) will be recruited for this study. Participant's psychiatric phenotypes, cognition, social cognition, and community functioning will be dimensionally characterized. Eye gaze perception will be assessed using a psychophysical task, and two metrics (precision, self-referential bias) that respectively tap into gaze perception disturbances at the visual perceptual and interpretation levels, independent of general deficits, will be derived using hierarchical Bayesian modeling. A subset of the participants (150 psychiatric patients, 75 controls) will additionally undergo multimodal fMRI to determine the functional and structural brain network features of altered gaze perception. The specific aims of this project are three-fold: (1) Determine the generality of gaze perception disturbances in psychiatric patients with prominent social dysfunction; (2) Map behavioral indices of gaze perception disturbances to dimensions of psychiatric phenotypes and core functional domains; and (3) Identify the neural correlates of altered gaze perception in psychiatric patients with social dysfunction. Successfully completing these specific aims will identify the specific basic deficits, clinical profile, and underlying neural circuits associated with social dysfunction that can be used to guide targeted, personalized treatments, thus advancing NIMH's Strategic Objective 1 (describe neural circuits associated with mental illnesses and map the connectomes for mental illnesses) and Objective 3 (develop new treatments based on discoveries in neuroscience and behavioral science).

Fatiguing Neuromuscular Electrical Stimulation Decreases the Sense of Effort During Subsequent Voluntary Contractions in Men

As voluntary muscle fatigue increases, the perception of the effort required to produce a particular level of force also increases. This occurs because we produce greater neural outputs from the brain to compensate for the fatigue-induced loss of force. Muscle fatigue can also be generated following bouts of neuromuscular electrical stimulation (NMES), a technique widely used for rehabilitation and training purposes. Yet the effects of NMES-induced fatigue on the perception of effort have never been tested. In this study, we thus evaluated how electrically evoked fatigue would affect the sense of effort. For this purpose, we used two psychophysical tasks intended to assess effort perception: (i) a bilateral matching task in which subjects were asked to contract the elbow flexors of their reference and indicator arms with similar amounts of effort and (ii) a unilateral matching task in which they produced controlled levels of isometric force with their indicator arm and rated their perceived effort using the Borg CR10 scale. These tasks were performed before and after the biceps brachii of the indicator arm was submitted to a fatiguing NMES program that generated maximal force losses of 10–15%. Contrary to voluntary muscle fatigue, the sense of effort decreased post-NMES in both tasks despite increased neural outputs to the elbow flexors of the fatigued indicator arm. This shows that the relationship between motor command magnitude and effort perception was completely modified by NMES. It is proposed that NMES alters the sensory structures responsible for effort signal integration.

Binaural spatial adaptation as a mechanism for asymmetric trading of interaural time and level differences.

A classic paradigm used to quantify the perceptual weighting of binaural spatial cues requires a listener to adjust the value of one cue, while the complementary cue is held constant. Adjustments are made until the auditory percept appears centered in the head, and the values of both cues are recorded as a trading relation (TR), most commonly in μs interaural time difference per dB interaural level difference. Interestingly, existing literature has shown that TRs differ according to the cue being adjusted. The current study investigated whether cue-specific adaptation, which might arise due to the continuous, alternating presentation of signals during adjustment tasks, could account for this poorly understood phenomenon. Three experiments measured TRs via adjustment and via lateralization of single targets in virtual reality (VR). Targets were 500 Hz pure tones preceded by silence or by adapting trains that held one of the cues constant. VR removed visual anchors and provided an intuitive response technique during lateralization. The pattern of results suggests that adaptation can account for cue-dependent TRs. In addition, VR seems to be a viable tool for psychophysical tasks.

A computational paradigm for real-time MEG neurofeedback for dynamic allocation of spatial attention

BackgroundNeurofeedback aids volitional control of one’s own brain activity using non-invasive recordings of brain activity. The applications of neurofeedback include improvement of cognitive performance and treatment of various psychiatric and neurological disorders. During real-time magnetoencephalography (rt-MEG), sensor-level or source-localized brain activity is measured and transformed into a visual feedback cue to the subject. Recent real-time fMRI (rt-fMRI) neurofeedback studies have used pattern recognition techniques to decode and train a brain state to link brain activities and cognitive behaviors. Here, we utilize the real-time decoding technique similar to ones employed in rt-fMRI to analyze time-varying rt-MEG signals.ResultsWe developed a novel rt-MEG method, state-based neurofeedback (sb-NFB), to decode a time-varying brain state, a state signal, from which timings are extracted for neurofeedback training. The approach is entirely data-driven: it uses sensor-level oscillatory activity to find relevant features that best separate the targeted brain states. In a psychophysical task of spatial attention switching, we trained five young, healthy subjects using the sb-NFB method to decrease the time necessary for switch spatial attention from one visual hemifield to the other (referred to as switch time). Training resulted in a decrease in switch time with training. We saw that the activity targeted by the training involved proportional changes in alpha and beta-band oscillations, in sensors at the occipital and parietal regions. We also found that the state signal that encodes whether subjects attend to the left or right visual field effectively switches consistently with the task.ConclusionWe demonstrated the use of the sb-NFB method when the subject learns to increase the speed of shifting covert spatial attention from one visual field to the other. The sb-NFB method can target timing features that would otherwise also include extraneous features such as visual detection and motor response in a simple reaction time task.

The worse eye revisited: Evaluating the impact of asymmetric peripheral vision loss on everyday function

In instances of asymmetric peripheral vision loss (e.g., glaucoma), binocular performance on simple psychophysical tasks (e.g., static threshold perimetry) is well-predicted by the better seeing eye alone. This suggests that peripheral vision is largely ‘better-eye limited’. In the present study, we examine whether this also holds true for real-world tasks, or whether even a degraded fellow eye contributes important information for tasks of daily living. Twelve normally-sighted adults performed an everyday visually-guided action (finding a mobile phone) in a virtual-reality domestic environment, while levels of peripheral vision loss were independently manipulated in each eye (gaze-contingent blur). The results showed that even when vision in the better eye was held constant, participants were significantly slower to locate the target, and made significantly more head- and eye-movements, as peripheral vision loss in the worse eye increased. A purely unilateral peripheral impairment increased response times by up to 25%, although the effect of bilateral vision loss was much greater (>200%). These findings indicate that even a degraded visual field still contributes important information for performing everyday visually-guided actions. This may have clinical implications for how patients with visual field loss are managed or prioritized, and for our understanding of how binocular information in the periphery is integrated.

Deconstructing eye contact perception: Measuring perceptual precision and self-referential tendency using an online psychophysical eye contact detection task.

Eye contact perception—the ability to accurately and efficiently discriminate others’ gaze directions—is critical to understanding others and functioning in a complex social world. Previous research shows that it is affected in multiple neuropsychiatric disorders accompanied by social dysfunction, and understanding the cognitive processes giving rise to eye contact perception would help advance mechanistic investigations of psychopathology. This study aims to validate an online, psychophysical eye contact detection task through which two constituent cognitive components of eye contact perception (perceptual precision and self-referential tendency) can be derived. Data collected from a large online sample showed excellent test-retest reliability for self-referential tendency and moderate reliability for perceptual precision. Convergence validity was supported by correlations with social cognitive measures tapping into different aspects of understanding others. Hierarchical regression analyses revealed that perceptual precision and self-referential tendency explained unique variance in social cognition, suggesting that they measure unique aspects of related constructs. Overall, this study provided support for the reliability and validity of the eye contact perception metrics derived using the online Eye Contact Detection Task. The value of the task for future psychopathology research was discussed.

Individual Differences in Multisensory Interactions:The Influence of Temporal Phase Coherence and Auditory Salience on Visual Contrast Sensitivity.

While previous research has investigated key factors contributing to multisensory integration in isolation, relatively little is known regarding how these factors interact, especially when considering the enhancement of visual contrast sensitivity by a task-irrelevant sound. Here we explored how auditory stimulus properties, namely salience and temporal phase coherence in relation to the visual target, jointly affect the extent to which a sound can enhance visual contrast sensitivity. Visual contrast sensitivity was measured by a psychophysical task, where human adult participants reported the location of a visual Gabor pattern presented at various contrast levels. We expected the most enhanced contrast sensitivity, the lowest contrast threshold, when the visual stimulus was accompanied by a task-irrelevant sound, weak in auditory salience, modulated in-phase with the visual stimulus (strong temporal phase coherence). Our expectations were confirmed, but only if we accounted for individual differences in optimal auditory salience level to induce maximal multisensory enhancement effects. Our findings highlight the importance of interactions between temporal phase coherence and stimulus effectiveness in determining the strength of multisensory enhancement of visual contrast as well as highlighting the importance of accounting for individual differences.

A simple three layer excitatory-inhibitory neuronal network for temporal decision-making

Humans and animals do not only keep track of time intervals but they can also make decisions about durations. Temporal bisection is a psychophysical task that is widely used to assess the latter ability via categorization of durations as short or long. Many existing models of performance in temporal bisection primarily account for choice proportions and tend to overlook the associated response times. We propose a time-cell neural network that implements both interval timing and temporal categorization. The proposed model can keep track of time intervals based on lurching wave activity, it can learn the reference durations along with their association with different categorization responses, and finally, it can carry out the comparison of arbitrary intermediate durations to the reference durations. We compared the model's predictions about choice behavior and response times to the empirical data previously gathered from rats. We showed that this time-cell neural network can predict the canonical behavioral signatures of temporal bisection performance. Specifically, (a) the proposed model can account for the sigmoidal relationship between the probability of the long choices and the test durations, (b) the superposition of choice functions on a relative time scale, (c) the localization of the point of subjective equality at the geometric mean of the reference durations, and (d) the differential modulation of short and long categorization response times as a function of the test durations.