Psychopathological Manifestations Research Articles

Coping Strategies and Psychopathological Responses Among Medical and Non-medical Professionals - a Cross-Sectional Online Survey.

Background: The SARS-CoV-2 pandemic was announced on March 11th, 2020, due to a surge of newly confirmed cases that significantly impacted populations worldwide, both directly and indirectly. Based on past epidemics research, the mental health implications of introduced restrictions should be expected and adequately addressed irrespective of the practiced profession.Objective: The study aimed to explore psychopathological responses, including post-traumatic stress disorder (PTSD), concerning coping strategy clusters during the COVID-19 pandemic among medical and non-medical workers.Methods: A cross-sectional web survey of the general population of internet users was performed from March 16th to April 26th, 2020, in Poland during the first peak of COVID-19 cases. A sample of 1,831 professionally active respondents, 64.0% of which pursuing a medical career, filled out General Health Questionnaire-28 (GHQ-28), The Impact of Event Scale-Revised (IES-R), and MiniCOPE, along with the socio-demographic questionnaire exploring personal as well as the work-related possibility of direct exposure to contagion and availability of proper protection, contact with the infected without accurate protective measures as well as the adequacy of workers when compared settings.Results: Individuals labeled with specific clusters had significantly different psychopathological manifestations. Irrespective of performed job maladaptive cluster was associated with significantly higher GHQ-28 and IES-R scores on total subscales and all subscales compared to those representing the non-specific and adaptive cluster. Similar findings were observed concerning the frequency of the GHQ-28 positive score. Moreover, the non-specific cluster was associated with significantly higher GHQ-28 total scores among medical professionals. However, GHQ-28 positive scores were significantly more frequent in medical workers using adaptive clusters when compared to non-specific. Such relations were not observed in the non-medical group.IES-R total and subscales' scores did not significantly vary within medical and non-medical groups when adaptive and non-specific clusters were compared. Pursuing a non-medical career was found to be a determinant of lower scores, while female sex was observed to be determinant of higher scores in both GHQ-28 and IES-R scales.Conclusions: Positive screening for psychopathological and PTSD symptoms was expected regardless of the analyzed groups' coping strategies. Given the dramatically developing situation of the COVID-19 pandemic, support initiatives grounded in research evidence may be essential for maintaining the mental well-being and resilience of both the medical and non-medical workforce.

Changes in Psychopathology and Mental Health Resilience.

Accelerated culture transition and contemporary post-truth mass cognitive distortions contribute to cognitive insecurity and substitution of facts with opinions. In this paper the impact of these changes on normal psyche and on psychopathological manifestations and mental health care is described. The consequences include drop of mental resilience, pathomorphosis of some clinical pictures, blurring of diagnostic boundaries, mimicry of psychopathology, and overdiagnosis. Their repercussions on mental health care and professional integrity are discussed, and particularly the need for shift of mental health care focus from protection to resilience is disputed.

The effect of anxiety, psychopathological symptoms and personality traits on response to treatment in male patients with anogenital warts: a prospective study.

In the era of precision medicine, identification of possible predictive factors of clinical response to treatment is fundamental. This need is particularly strong for anogenital warts (AGW), because there are several treatment modalities with different clearance and recurrence rates. However, data regarding the effect of mental health parameters on response to treatment in patients with AGW are lacking. The purpose of the present study was to evaluate the association between patients' mental health parameters and AGW treatment outcomes. This was a single-centre, prospective study that included newly diagnosed male patients with AGW. At their initial visit, all patients completed the State-Trait Anxiety Inventory (STAI), the Symptom Checklist-90-Revised (SCL-90-R) and the Eysenck Personality Questionnaire (EPQ) questionnaires, which evaluate anxiety, psychopathological manifestations and personality traits, respectively. All patients received cryotherapy until clearance of lesions and were followed up for 18months for detection of recurrences. The study included 167 male patients. The mean number of days for AGW clearance was 89±65. During the 18-month follow-up, 28% of participants showed a recurrence, after a mean number of 150±132days. No statistically significant association was detected between questionnaires scores and (a) time needed for AGW clearance, (b) time until 1st recurrence and (c) number of recurrences. If confirmed, our findings indicate that we may not need to modify our AGW treatment plan according to a patient's mental health profile.

Co-occurrence Pattern of Posttraumatic Stress Disorder and Depression in People Living With HIV: A Latent Profile Analysis.

Background: The comorbidity of posttraumatic stress disorder (PTSD) and depression is common among people living with the HIV (PLWH). Given the high prevalence and serious clinical consequences of the comorbidity of these two disorders, we conducted a latent profile analysis to examine the co-occurrence pattern of PTSD and depression in PLWH.Methods: The data for this cross-sectional study of PLWH were collected from 602 patients with HIV in China. A secondary analysis using latent profile analysis was conducted to examine HIV-related PTSD and depression symptoms.Results: A four-class solution fits the data best, with the four classes characterized as asymptomatic (42.9%), mild symptoms (33.9%), low to moderate symptoms (19.8%), and high to moderate symptoms (3.4%). The severity of PTSD and depression symptoms was comparable in this solution, and no group was dominated by PTSD or depression.Conclusion: The absence of a distinct subcluster of PLWH with only PTSD or depression symptoms supports that PTSD and depression in PLWH are psychopathological manifestations after traumatic exposures. Health care staff should pay more attention to the existence of comorbid symptoms of individuals, develop integrated interventions for the symptoms cluster, and evaluate their effectiveness in clinical practice.

Associations Between Dimensional Psychopathology and Brain Volume in Children

Childhood is an important time for the manifestation of psychopathology. Psychopathology is characterized by considerable comorbidity which is mirrored in the underlying neural correlates of psychopathology. Both common and dissociable variations in brain volume have been found across multiple mental disorders in adult and youth samples. However, the majority of these studies used samples with broad age ranges which may obscure developmental differences. The current study examines associations between regional gray matter volumes (GMV) and psychopathology in a large sample of children with a narrowly defined age range.

Insights into the Pathophysiology of Psychiatric Symptoms in Central Nervous System Disorders: Implications for Early and Differential Diagnosis

Different psychopathological manifestations, such as affective, psychotic, obsessive-compulsive symptoms, and impulse control disturbances, may occur in most central nervous system (CNS) disorders including neurodegenerative and neuroinflammatory diseases. Psychiatric symptoms often represent the clinical onset of such disorders, thus potentially leading to misdiagnosis, delay in treatment, and a worse outcome. In this review, psychiatric symptoms observed along the course of several neurological diseases, namely Alzheimer’s disease, fronto-temporal dementia, Parkinson’s disease, Huntington’s disease, and multiple sclerosis, are discussed, as well as the involved brain circuits and molecular/synaptic alterations. Special attention has been paid to the emerging role of fluid biomarkers in early detection of these neurodegenerative diseases. The frequent occurrence of psychiatric symptoms in neurological diseases, even as the first clinical manifestations, should prompt neurologists and psychiatrists to share a common clinico-biological background and a coordinated diagnostic approach.

A Preliminary Test of the Efficacy of Brief Self-Administered Behavioral Interventions for Rumination.

Rumination is theorized to be a cognitive avoidance process that is implicated in several manifestations of psychopathology. Few interventions directly target rumination as a core process maintaining emotional disorder symptoms. This pilot study compared the feasibility and preliminary efficacy of self-directed behavioral approaches for reducing rumination. Participants (N = 60) with elevations in rumination were randomized to 3 weeks of self-directed interventions: (a) scheduled rumination time; (b) a strategy combining mindfulness, shaping, and disengagement strategies; or (c) self-monitoring control. Both active treatment conditions outperformed self-monitoring control on post-treatment depression scores. Scheduled rumination time significantly outperformed the other two conditions on measures of rumination and worry. No between-group differences emerged on the secondary outcome (i.e., anxiety symptoms). Brief, self-directed, behavioral interventions targeting rumination are feasible and demonstrate preliminary efficacy. Scheduled rumination time shows moderate to large effects. The use of a small, non-treatment seeking sample was the primary limitation.

Falling into a burning ring of fire: A case of psychosis unmasking hidden neurosyphilis

IntroductionThe first description of syphilis was made in Europe around the year 1493, and although perceived as a disease relegated to its historical importance, recent studies demonstrate that the prevalence of these infections is on the rise. Spanning decades after initial infection, 30% of affected individuals without treatment may develop tertiary syphilis, which includes neurosyphilis. Its notoriously “chameleon-like” presentation implies the necessity to not overlook neurosyphilis as a differential diagnosis in psychiatric settings.ObjectivesCase report study and discussion.MethodsThe authors present a case of affective and psychotic symptoms (including auditory and visual hallucinations and persecutory delusions) of rapid onset in a 61-year old woman without prior psychiatric history. A clinical investigation was conducted, which subsequently revealed a positive Venereal Disease Research Laboratories (VDRL) test. A lumbar puncture was performed and cerebrospinal fluid analysis confirmed neurosyphilis.ResultsSteady improvements in initial psychopathological manifestations were noted after completing recommended treatment for neurosyphilis. After discharge, the patient was medicated with an antidepressant and antipsychotic, demonstrating a complete return to baseline mentation and functionality on follow-up.ConclusionsThis case demonstrates the vital importance of considering syphilis in our differentials, especially due to the wide range of manifesting psychiatric symptoms. Although considered a disease of the past, this case reminds us that syphilis remains present in our society and its timely diagnosis and treatment can ameliorate the debilitating psychopathological manifestations of the disease. Due to the potential difficulties in identifying this great imitator, routine screening tests are still recommended in the psychiatric setting.

Impact of non-farmacological methods on improvement cognitive function in epilepsy

IntroductionThe quality of life of patients with epilepsy, their social activity and functioning depends not only on the presence of epileptic seizures, but also on the level of cognitive decline.ObjectivesThe object of our study is impact of non-pharmacological methods on cognitive functions, decreasing of which deteriorates social activity in patients with epilepsy.MethodsWe have studied the features of clinical and psychopathological manifestations in patients suffering from epilepsy. The study covered 27 patients who were in inpatient care. The following psychodiagnostic techniques were used: the Toronto Cognitive Assessment TorCA, the MOCA and the MiniMult tests, Patient Social Functioning Questionnaire. Currently, a group of patients with cognitive decline cause by epilepsy is undergoing remote cognitive training on one of an online platforms, under our observation. Correction occurs throughout regular daily performance, assessment of cognitive functions is carried out on three indicators: attention, memory and thinkingResultsThe following results of the study were observed: initially decreased memory in 88,8 % patients and the level of cognitive decline were directly proportional to the duration of the illness, this category of patients has reduced activity and limited social contacts.The result of the use of cognitive training is an increase in all three indicators.ConclusionsThe results of the study indicate the need for further study of the features of cognitive disorders in epilepsy and the use of methods of psychotherapeutic correction.

Affective and cognitive impairments in patients with epilepsy

IntroductionThe most common psychiatric conditions in epilepsy are depression, anxiety, behavioral, psychotic disorders and cognitive disorders as well as those which can be caused by convulsive seizures.ObjectivesThe aims of the research were to define cognitive and affective impairments in patients with epilepsy and their quality of life. Since the presents of cognitive impairments and affective disorders have a considerable impact on the functioning of patients, their socialization and the level of their disability.MethodsWe studied the features of clinical and psychopathological manifestations in patients suffering from epilepsy. The study covered 100 patients (47 men and 53 women) who were in inpatient care. The following psychodiagnostic techniques were used: the test of 10 words of Luria, the MOCA test, the Münsterberg test, Mini-Mult test, the quality of life scale, the Hamilton scale of depression and anxiety.ResultsThe following data of the study were observed: 88 % patients had decreased memory, 38% had symptoms of depression, 28% had mild situational or neurotic depression, 8% had moderate depression, 2% had severe depression, 20% had a state of severe anxiety, 16% had symptoms of anxiety. The average rate of quality of life among all examined people was 67.5 out of 100.ConclusionsThe results of the conducted research indicate the need for further study of the features of the comorbid pathology in epilepsy and development and implementation pharmacological and nonpharmacological methods for treatments of epilepsy.

The difficult problem of the crime of impetus: A proposal for an integrated analysis of complex cases

IntroductionThe evaluation of the crime of impetus poses problems in seeking clinical elements that configure the total or partial defect of mind. Even in the presence of acute psychotic syndromes it is difficult to identify a psychopathological picture that almost overlaps with the times and methods of the crime itself.ObjectivesFrom a longitudinal perspective, this contribution intends to propose a method of integrating data derived from psychopathological, criminological and forensic psychiatric analyzes, in order to identify the link between them and the criminal act that qualifies or excludes the mental defect.MethodsIn the analysis of a criminal event generated during an acute psychotic episode, it’s described the logic and methodology of integrating criminological, psychopathological and psychiatric forensic data for which it was possible to identify the pathological nature of the event.ResultsThe psychopathological analysis allowed the identification of psychotic manifestations before and after the crime. The criminological analysis included the decision to commit the crime, within a framework of alteration of the reality examination and recognized the delusional purpose in the same methods of carrying out the crime. So, the forensic psychiatric analysis clarified the continuity of the psychopathological manifestations in the time frame in which the crime was planned, organized and committed and to codify such manifestations as an acute psychotic episode.ConclusionsAlthough it’s not sufficient to circumscribe the criminal act between two pathologically relevant moments, this contribution shows how integrating different methods of analysis makes it possible to identify the quality of the behavior intended as a crime.

Cognitive impairments in patients with treatment resistant epilepsy: Complex rehabilitation in university clinic

IntroductionСognitive deficit significantly affects the quality of life of patients. Aims of research was detection of cognitive impairments of varying degrees in epilepsy, and as well as studying the results of complex treatment in conditions of University clinic, physical and psychological rehabilitation, cognitive training and VNS included.ObjectivesWe studied the features of clinical and psychopathological manifestations of cognitive impairments in patients suffering from epilepsy.MethodsThe study was attended by 100 patients (35 men and 65 women) who were inpatient care. The following psychodiagnostic techniques were used: the Toronto Cognitive Assessment TorCA, the test of 10 words of Luria, the MOCA test, the Münsterberg test, the quality of life scale, the Hamilton scale of depression and anxiety.ResultsMCI was observed in 88 % patients, dementia in 12 % (50 % - mild dementia, in 24 % - moderate dementia and in 16% - severe dementia). We used non-pharmacological rehabilitation methods for correction of cognitive impairment in epileptic patients with MCI and mild dementia during 3 mounth.. Improving of cognitive function was observed in 48 % patients, stable level of cognitive function - in 36 %, progressing of cognitive imparment - in 16 % patiens with epilepsy.ConclusionsThe results of the conducted research indicate the need for further study of the features of cognitive disorders in pharmacologically treatment resistant epilepsy and implementation of training aimed at improving cognitive function and preventing the progression of cognitive impairment in complex treatment of those patients.

The prevalence of psychopathological symptoms in population during the COVID-19 pandemic

IntroductionThe COVID-19 pandemic has caused significant lifestyle changes for the world’s population. The infection poses a threat to mental health due to direct invasion of the central nervous system of SARS-CoV-2, as well as as a source of mental stress associated, in particular, with the deformation of the structure of interpersonal communications under quarantine conditions.ObjectivesThe study was conducted to comparatively study the phenomenology and severity of psychopathological manifestations in quarantined and non-quarantined people during the COVID-19 pandemic.MethodsFrom April 18 to June 15, 2020, an online questionnaire “Symptom List 90” (SCL-90) was conducted among 837 adults in Russia, Kazakhstan, Belarus and other countries. 426 respondents were in strict home quarantine; 302 observed social distancing, but could go to work; 109 were not socially isolated.ResultsThere was a significant difference in the overall severity index (GSI) between strictly quarantine and non-quarantine groups with GSI values of 0.51 (0.24; 0.99) and 0.33 (0.16; 0.75), respectively (p = 0.001). Indicators of anxiety, depression, somatization, obsessive-compulsive symptoms, phobic anxiety, hostility and psychoticism were also significantly higher in quarantined individuals than in non-quarantined individuals (p <0.05).ConclusionsThe results of the analysis indicate that in a pandemic, the most susceptible to psychopathological disorders are those living in the most severe quarantine, while the contingent whose lifestyle changes little under these conditions shows the best indicators of mental health. These data indicate the need to optimize the system of psychiatric preventive and curative care for the population in a pandemic.Conflict of interestNo significant relationships.

Problematic internet use: The effect of comorbid psychopathology on treatment outcomes

Problematic Internet use (PIU) behaviours involve one's maladaptive Internet use and have been often described as secondary manifestations of pre-existing psychopathology. Furthermore, different profiles of PIU sufferers have been proposed. However, little is known of the impact these may be having on treatment responses. Thus, this study aims to investigate the psychopathological profiles of those who seek treatment for PIU within a specialised public outpatient unit and whether these influence treatment outcomes. This research utilised 203 treatment seekers of the Specialized Department of Problematic Internet Use (SD-PIU) of the Psychiatric Hospital of Attica, in Greece (mean age = 26.02; SD = 7.9). To assess psychopathology, the Symptom Checklist-90 Revised (SCL-90-R) was used. Treatment responses were reported either as completed, continued, or drop out. A Latent Class/Profiling-Analysis (LCA) was performed, guided by variations across the SCL-90-R psychopathologies. It indicated two naturally occurring profiles of comorbid psychological symptoms; 66% were classified as the “High Comorbidity” (HC) and 34% as the “Low Comorbidity” (LC) profile. Regarding treatment outcomes, LC patients presented with significantly lower dropout rates and higher levels of completion. The present study poses imperative clinical implications regarding the necessity of specialized treatment planning based on the different PIU treatment seekers psychopathological comorbidities.

The challenge of treating Roma outpatients in the Eastern Macedonia and Thrace region of Greece.

The Roma people are one of the most unknown and interesting nations in Europe. Although they are severely marginalised within European societies, they have greatly influenced European culture. Despite this fact, there is a deep prejudice against them. In the region of East Macedonia and Thrace, a significant proportion of the population are Roma. Their marginalisation leads to many problems and also affects their mental health. Their psychopathological manifestations differ from the majority population. They express more somatic complaints and higher overall stress in a histrionic background. The main obstacles regarding their mental health issues and treatment appear to be the following: gender inequality, illiteracy and lack of cultural sensitivity in healthcare system. Although all of these obstacles must be removed, some are easier to remove than others. Cultural sensitivity could be applied by using more culturally sensitive diagnostic tools, improving overall training for mental health professionals and treating Roma wherever they seek help, because they often have a nomadic style of living. Telemedicine can be quite useful in serving this goal. Improving their educational status and addressing gender inequalities issues, on the other hand, are more difficult and long-term goals.

Association of gray matter volumes with general and specific dimensions of psychopathology in children.

Childhood is an important time for the manifestation of psychopathology. Psychopathology is characterized by considerable comorbidity which is mirrored in the underlying neural correlates of psychopathology. Both common and dissociable variations in brain volume have been found across multiple mental disorders in adult and youth samples. However, the majority of these studies used samples with broad age ranges which may obscure developmental differences. The current study examines associations between regional gray matter volumes (GMV) and psychopathology in a large sample of children with a narrowly defined age range. We used data from 9607 children 9-10 years of age collected as part of the Adolescent Brain Cognitive DevelopmentSM Study (ABCD Study®). A bifactor model identified a general psychopathology factor that reflects common variance across disorders and specific factors representing internalizing symptoms, ADHD symptoms, and conduct problems. Brain volume was acquired using 3T MRI. After correction for multiple testing, structural equation modeling revealed nearly global inverse associations between regional GMVs and general psychopathology and conduct problems, with associations also found for ADHD symptoms (pfdr-values ≤ 0.048). Age, sex, and race were included as covariates. Sensitivity analyses including total GMV or intracranial volume (ICV) as covariates support this global association, as a large majority of region-specific results became nonsignificant. Sensitivity analyses including income, parental education, and medication use as additional covariates demonstrate largely convergent results. These findings suggest that globally smaller GMVs are a nonspecific risk factor for general psychopathology, and possibly for conduct problems and ADHD as well.

The prevalence and mental comorbidity of internet-dependent behavior in adolescents of Central Siberia

To study the prevalence of Internet addiction (IA) in adolescents in Central Siberia and the association of IA with mental health problems. The study included 2950 adolescents (44.7% boys and 54.3% girls), aged 11-18 years (mean age 14.5±1.3). Younger adolescents (11-14 years old) accounted for 52.4%, senior ones (15-18 years old) did 47.6%. The Chen scale (CIAS) with a cutoff level of 65 points was used to evaluate IA. The overall CIAS value of 27-42 points was regarded to be adaptive Internet use (AIU); 43-64 points being non-adaptive Internet use (NIU); 65 points and above were considered to be IA. Mental health was assessed using SDQ, which includes five scales: 1) prosocial behavior; 2) emotional symptoms; 3) behavior problems; 4) hyperactivity; 5) peer problems. The prevalence of AIU is 50.3% (55.9% among boys and 45.6% among girls, p<0.01), NIU was found in 42.9% (38.9/46.3%, p<0.001), IA occurred in 6.8% (5.1/8.2%, p<0.001). The prevalence of IA among adolescents, aged 11-14 years old, was 5.9%, between the ages of 15-18 it was 7.8% (p=0.04). In the AIU group, emotional symptom** were observed in 5.1% of adolescents, behavior problems in 6.1%, hyperactivity in 3.6%; in the NIU group - in 14.9%, 11.7% and 9.4% of adolescents; in the IA group, there were 34%, 24% and 26% of adolescents, respectively. In terms of odds ratio (OR), the greatest effect size was observed for hyperactivity (OR=5.23, p<0.001) and emotional disorders (OR=4.85, p<0001). The prevalence of IA is 6.8%. IA is more common in girls and increases with age. IA is associated with mental health problems, the greatest effect size is observed for hyperactivity and emotional disorders. The incidence of psychopathological manifestations increases depending on the degree of impairment in network behavior.

Affective Dependence: From Pathological Affectivity to Personality Disorders: Definitions, Clinical Contexts, Neurobiological Profiles and Clinical Treatments

Starting from the general concept of affectivity, the present work focuses on the clinical, neurobiological, and dysfunctional aspects of the morbid condition, when dysfunction gradually becomes first an affective addiction and then a symptom of a psychopathological personality picture, thus suggesting a multidimensional treatment. From affective dependence to personality disorders, about the dynamics of human bonding, to the implications determined by the attachment theory, trying to demonstrate that the clinical category of affective dependence cannot be considered simply a form of behavioral dependence, as erroneously done in the last decade, but as a symptom of a psychopathological manifestation of personality, in a framework of diagnostic transversality.

COMPLEX MEDICAL-PSYCHOLOGICAL AND SOCIAL SUPPORT OF PARTICIPANTS OF COMBAT

Introduction. This work provides the results of author’s own research which are based on the analysis of characteristics of the post-stress personality disorders (PSD) taking into account the comorbid addictive behaviour among military personnel.During the study, it was found with PSD, the most pronounced addictions are cannabinoid, alcoholic and psychostimulants dependencies. Taking into account the tendency to increase number of people with psychopathological disorders and addictive behaviour manifestations in the modern Ukraine, the problem of prevention, treatment and support of people who were in the ATO area is acute now.Goal. Determination of markers of medical, psychological and social support.Research methods: theoretical, socio-demographic, clinical and psychopathological, psychodiagnostic, follow-up, clinical and anamnestic, statistical.Results. In order to develop a model of pharmacotherapy for this group of persons, during the 2014-2018 years, 219 people were examined at the age from 21 to 56 years, of which 18 persons were not included in the study according to the inclusion/exclusion criteria. Of surveyed people (201 persons), 59 people were diagnosed with PSD, including 32 people with comorbid adductions.We carried out a screening diagnostic assessment of the needs of servicemen, during which we identified the main requests for the need for corrective measures, their attitude and desire to take part in an experimental program to restore normal social life and restore normal life. According to the results of the study, it was found that the spectrum of needs covers all three spheres of a person’s life: biological, psychological and social. It was possible to identify the main targets of psychotherapy and draw up a plan of the main activities. The general goal of psychocorrectional measures for each of the studied groups was the restoration of normal processes of life of the individual and the restoration of normal social interaction.Conclusions. The developed measures gave us the opportunity to effectively influence all links of pathogenesis, based on the biopsychosocial model of addiction. In the process of treatment, taking into account the recommendations of the MOH on the treatment of military personnel, were improved certain stages of pharmacotherapy as the basis for further active psychosocial and psychosocial support, which will create the basis for the normalization of their livelihoods and the possibility of military-professional recovery.

Diagnostics, psychotherapy and psychoprophylaxis in the complex treatment of somatic patients with mental and behavioral disorders, who use alcohol with harmful effects

The article presents the results of a study of persons who filed somatic complaints to a general practitioner — family doctor in an outpatient clinic in Kyiv and use alcohol with harmful consequences. From the standpoint of evidencebased medicine, on the basis of an interdisciplinary approach, biological, psychological and social patterns of the formation of mental and behavioral disorders in persons who have consumed alcohol with harmful consequences have been determined. On this basis, a system of specialized medical care has been scientifically substantiated, developed and implemented, which is a complex of medical, psychological, educational and social measures developed taking into account the influence of biopsychosocial factors in the genesis of mental and behavioral disorders and aimed at preventing or eliminating clinical and psychopathological symptoms, reduction or refusal of respondents from using alcohol with harmful consequences and thereby improving their somatic state, reducing sick leave, ensuring a decent level of social functioning in everyday life. The specified system includes a combination of psychopharmacotherapeutic influences, differentiated depending on the clinical specifics of mental and behavioral disorders and types of personal and behavioral responses. The introduction of this system in health care institutions and specialized universities has proven its effectiveness in reducing clinical and psychopathological manifestations, as well as changes in the social functioning and quality of life of patients.