Background: Khat, a well-known natural stimulant from the Catha edulis plant, a flowering evergreen tree or large shrub of the Celastracea family is taken in few parts of southern province. Being adjacent to Yemen, Khat chewing is a common habit among the population in the Jazan region. khat eating is associated with many health ailments like depression, stress anxiety. Objectives: 1. To estimate the prevalence of depression, anxiety and stress in khat chewers 2. To assess the psychological disorders in khat chewers. Methodology: A cross-sectional study (survey) conducted and sample size collected with pre designed questionnaire. Data entered in Microsoft excel and processed in SPSS version 23 and the results tabulated. Univariate and multivariate analysis with multilogistic regression done. Results: Majority of participants were males and were 21 years old or younger. Notable difference identified between urban (40%) and rural (60%) and this difference was identified as potential distinction in the psychological behaviour of the students. Odds ratio was found to be high in males and in >21-year-old students when compared with females. GPA showed significant difference when observed with psychological status. GPA scores less than 3.75 were found to have more psychological disturbances than GPA>3.75. Interquartile range among depression, anxiety and stress higher among khat chewers when compared with non-khat chewers and the difference found to show high statistical significance. (P<0.01). Conclusion: Khat chewing in this area found to be significantly high in students so continuous health education shall be the priority for the policy makers
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