Psycho-emotional Manifestations Research Articles

Characteristics of Psychoemotional Manifestations of Laboratory Rodents Undergoing Surgery when Modeling Preoperative Stress.

We studied psychoemotional characteristics and the blood level of corticosterone in sexually mature male C57BL/6 mice (n=40): intact (control), after simulating preoperative stress and surgery, after surgery, and after anesthesia alone. It was found that the anxiety index calculated on the basis of testing in the elevated plus maze was significantly higher in both groups of operated animals. The mice of both operated groups and animals exposed to anesthesia alone showed increased anxiety. Symptoms indicating a high probability of transition of anxiety into a psychoemotional disorder have been recorded.

Prospects of application of non-hormonal drug Femo-Klim in complex therapy of menopausal disorders of medium severity in patients with cancer in anamnesis

Objective. To study the possibility of using Femo-Klim preparation in the treatment of menopausal disorders of medium severity in gynecologic oncologic patients. Material and methods. Seventy-eight female patients with menopausal syndrome of moderate severity participated in the study. The patients were randomly divided into 2 groups: the main group (n=40) – patients received Femo-Klim preparation; the comparison group (n=38) – patients did not receive the examined preparation. Results. After 6 months of the study the dynamics of menopausal manifestations in the main group amounted to -0.9, in the comparison group – -0.7, somatic manifestations – -0.55 and -0.15 respectively, psychoemotional manifestations – -0.8 and -0.5 respectively (p<0.05). The level of anxiety in the main group decreased by 60% compared to the comparison group. Bone mineral density increased by 2.6% in the main group and decreased by 1.4% in the comparison group (p<0.05).

Alternative therapy of menopausal vegetative disorders in women taking the metabolic status into account

Research objectives: to study the clinical effectiveness of alternative complex therapy of vegetative syndrome in menopausal patients using L-arginine and xylitol drugs. Materials and methods. The clinical prospective study included 50 patients in the early postmenopausal period with natural menopause, neurovegetative and psychoemotional manifestations of the climacteric syndrome. According to the Life extension strategy, patients received intravenous L-arginine (Tivortin drug) and xylitol solution with electrolytes (Xylat drug) for endothelial protection and correction of insulin resistance in order to treat climacteric syndrome. Modified Kupperman menopausal index, serum triglyceride, cholesterol, high-density lipoprotein, low-density lipoprotein, and very-low-density lipoprotein levels were determined in all women. Examinations were performed before the start of therapy and 3 months after the end of treatment.Results. The Life extension therapeutic strategy as an alternative comprehensive therapy of the vegetative syndrome in menopausal patients contributed to a reliable reduction of the manifestations of the climacteric syndrome. The advantage of combined therapy involving L-arginine and xylitol was manifested in a significant decrease in diastolic blood pressure (p = 0.043); reduction of the Kupperman index (p = 0.002) and the average score of vasomotor symptoms (p = 0.02). There was also a significant decrease in the serum level of insulin (p = 0.00007), HOMA index (p = 0.01), low-density lipoproteins (p = 0.04), and triglycerides (p = 0.03). The selected therapy was well tolerated during the observation period.Conclusions. The combined therapy involving L-arginine and xylitol in the early postmenopausal period with neurovegetative and psychoemotional manifestations of the climacteric syndrome had a pronounced clinical effect, which consisted in a significant reduction of vegetative disorders and stabilization of carbohydrate and lipid metabolism. The given therapeutic strategy can be considered as an alternative therapy in patients with climacteric disorders when phytotherapy is ineffective and when there are contraindications or limitations to menopausal hormone therapy. The results of this study showed the safety of the Life extension strategy.

MINUSES AND UNEXPECTED ADVANTAGES OF THE OLD WISTAR RATS’ BODY REACTION AT MODELING POST-TRAUMATIC STRESS DISORDER

Old Wistar rats exhibit the same general signs of a PTSD-like condition as young animals, when modeling post-traumatic stress disorder (PTSD). At the same time, a number of behavioral features, psycho-emotional manifestations and myocardial state were revealed in old rats. For the first time, it was found a sharp rise in the level of circulating testosterone, which contributes to a more rapid decision on the direction of movement in the labyrinth space under stress in old rats, in contrast to young ones. The index of the ratio of testosterone to corticosterone levels can serve as a guideline for dividing the rat population into low- and high-anxiety individuals when modeling PTSD. The data on dysfunctional accumulation of mitochondria in the myocardium of intact and stressed old rats are priority. The information obtained may be useful in the development of drugs for the devastating consequences of PTSD, as well as senile changes in the myocardium.

Hysterectomy with opportunistic salpingectomy during the menopausal transition as a predictor of climacteric disorders

Data on ovarian dysfunction after hysterectomy are found in literary sources, but the nature of changes in the hormonal profile, its chronological sequence, the issue of prognosis and possible preventive measures, even in the case of preservation of ovarian tissue, remain contradictory and fragmentary, which prompted the conduct of this research. The aim of the research is to assess the risk of menopausal disorders after hysterectomy with opportunistic salpingectomy during the menopausal transition. Research materials and methods.A comprehensive assessment of the long-term consequences of hysterectomy in 160 women of reproductive age was carried out. Risk factors were identified during a general clinical examination, based on anamnestic data. Indicators were evaluated in the examined women. Inclusion criteria: age of menopause transition, hysterectomy due to benign uterine pathology, patient's consent to participate in the study. Research results. The data obtained by us after 12 months from the moment of surgical intervention demonstrate neurovegetative and psychoemotional manifestations in 87 patients - 46.25%. Conclusions. 12 months after GE with opportunistic salpingectomy, 46.25% of patients have a gradual formation of components of the menopausal syndrome. age older than 45, hysterectomy, hormonal therapy of benign uterine pathology demonstrate a connection with the development of metabolic disorders in the distant postoperative period, and their combined effect increases the risk of their development.

Peculiarities of psychomotor development of children with autism spectrum disorders as a basis for correcting their motor activity

In the article, based on the study of scientific and scientific-methodical literature, pedagogical observations and personal experience of working with autistic children, an analysis and generalization of autistic spectrum disorders, which manifest themselves in early childhood and are considered one of the severe psychophysical development disorders of this category of children, is carried out. It is noted that the priority directions of correctional and developmental work with autistic children, which are determined by leading scientists, are based on the need to solve the tasks of social behavior development, the formation of emotional states, the main phases of socialization and adaptation of these children, however, they do not include the correction and development of their motor activity. Therefore, the article reveals the relationship between motor activity of autistic children and other types of activity – intellectual, speech and emotional. The peculiarities of motor activity and behavior disorders of this contingent of children have been systematized. It was found that motor development disorders in children with autism spectrum disorders are characterized by its delay, the presence of motor stereotypes, motor retardation, low plasticity, insufficiently developed coordination of movements, underdevelopment of fine motor skills, difficulties in learning motor skills and skills, etc. A complex of issues has been identified that serve as the main guidelines for specialists who work with the specified contingent of children. The necessity and importance of solving the tasks of correcting and developing the motor activity of autistic children, taking into account their psychophysical development features, is theoretically substantiated. Based on the positive psycho-emotional manifestations of their personality in the process of development (interests, tendency to imitate, manipulation of objects, the need to study their properties, etc.), approaches, means and methods of education are determined.

Influence of hysterectomy due to leiomyoma on woman’s psychological status

The objective: to study the clinical-psychopathological features and psycho-emotional symptoms and borderline mental disorders in women of reproductive age after hysterectomy due to leiomyoma.Materials and methods. An assessment of the psychological state of 160 women after hysterectomy for leiomyoma was carried out. 90 patients of them (average age – 45.9±1.3 years old) had transvaginal hysterectomy, both classic and laparoscopically assisted one with opportunistic salpingectomy (I group) and 70 patients (average age – 47.2±1.6 years old) – abdominal hysterectomy with opportunistic salpingectomy (II group). The control group included 50 women 45.7±1.3 years old with asymptomatic leiomyoma. Clinical psychopathological, anamnestic and experimental psychological methods were used. Pathopsychological methods included methods of visual presentation of the personality profile using the Minnesota Multifaceted Personality Questionnaire. The survey was conducted at the pre-operative period, during the adaptation period and during 12 months. Statistical processing of monitoring data was carried out according to the φ-criterion using the statistical analysis software package STATISTICA v. 10 and Microsoft Office Excel application. Results. The results of the questionnaire determined that 44 (48.89 %) patients of the I group and 33 (47.14 %) women of the II group had disorders related to anxiety, and 6 (6.67 %) and 5 (7 .14 %) of the patients of both groups, respectively, were diagnosed depression before surgical treatment. After hysterectomy the number of patients with an anxiety disorder increased to 52 (57.78 %) in the I group and 41 (52.57 %) – II group, with depression – to 10 (11.11 %) and 8 (11.43 %) women, respectively. However, the psychopathological analysis with psychologists in 12 months after hysterectomy determined affective symptoms in 11 (15.7±7.0 %), and latent depression with a somatopsychic correlation, manifested by a feeling palpitation, cardialgias, vegetative disorders was found in 8 (11.4±6.0 %) cases. The type of personality accentuation influenced the development of psychoemotional manifestations. In this structure, the largest rate consisted of psychoasthenic and hysterical character traits. The age of the patient was important when analyzing additional psychological factors. Women under 44 years old associated hysterectomy with loss of femininity with premature aging of the organism. The patients with successful implementation of their role in the family and society had better postoperative psychological adaptation.Conclusions. There is a trend toward an increased number of anxiety and depressive disorders after hysterectomy in women with leiomyoma. After 12 months, affective symptoms were present in 11 (15.7±7.0 %) cases and in 8 (11.4±6.0 %) cases – hidden depression. Postoperative rehabilitation should include a consultation with a psychologist to identify and treat borderline mental disorders, which will lead to the initiation of compensatory and adaptive reactions of the body and the normalization of the psycho-emotional status.

DETERMINATION OF SOMATIC, NEUROLOGICAL AND PSYCHO-EMOTIONAL MANIFESTATIONS OF THE ACUTE AND POSTCOVID PERIOD IN PATIENTS WITH A MILD COURSE OF COVID-19 IN WARTIME.

The aim: To analyze the typical symptom complex at the stage of COVID-19 acute phase in the systemic relationship with somatic, psychosomatic, and neurological manifestations. Materials and methods: The collection of primary material was performed by clinical-anamnestic method, laboratory, and sociological examination of patients treated out patiently. Summarizing of the results was performed according to the analysis of 100 completed cases of COVID-19 in patients aged 35-45 years (50 men and 50 women) who had no concomitant chronic pathology, and patients did not receive any vaccine dose before the disease (acute COVID-19) and during the next follow-up period (6 months). Results: The data of the analysis allowed us to make a grounded conclusion about the syndromic heterogeneity of COVID 19 in a standardized patients group with a mild course. Conclusions: the highest number of symptoms in the postcovid period by frequency, polymorphism, and life quality impact was found in the group of patients with subjectively tolerate acute COVID-19 most easily. Patients whose acute episode meets the mild criteria have pronounced neurological and psychoemotional manifestations during the postcovid period.

Features of postcovid syndrome in patients with rheumatic diseases

Purpose of the study. To study the frequency and structure of postcovid syndrome (PCS) in patients with rheumatic diseases (RD).Materials and methods. The study included 70 patients with RD who had a coronavirus infection during the year. A questionnaire was carried out on the severity of the coronavirus infection, persisting symptoms in the postcovid period. Questionnaires of anxiety and depression, sleep quality were used, the activity of RD was assessed.Results. Manifestations of PCS occurred in 50 (71 %) patients, of which 47 (67 %) had 2 or more manifestations. PCS was observed equally often in patients with different severity of infection. Such the symptoms of PCS as weakness, arthralgia, increased blood pressure, shortness of breath, tachycardia prevailed during 3 months after COVID-19. Half of the patients had a decrease in the severity of weakness, arthralgia and shortness of breath after 6 months, but the destabilization of blood pressure and tachycardia remained at the same level. Such the psychoemotional manifestations of PCS as moderate depression, memory impairment, insomnia were observed.Conclusions. More than 2/3 of patients with RS who have undergone COVID-19 are faced with PKS. In 1/3 of the examined patients with RD the duration of the persistence of symptoms of PCS exceeds 6 months after infection. After revealing of blood pressure destabilization in patients with rheumatic diseases, it is advisable to assess cardiovascular risks in patients who have undergone COVID-19.

Use of complementary medicine in autoimmune diseases of the nervous system

The relevance of the study is due to the lack of complete understanding of the formation of psychopathological symptoms in trigeminal neuralgia (TN) in dynamics before and after surgical treatment. Moreover, currently, there is no algorithm for conducting psychotherapeutic measures for TN patients. The purpose of the study: Examination of psychic disorders in TN patients. Methods: Severity of anxiety, depression, obsessive and phobic disorders, the duration of pain persistence after surgery, and accentuation of personality were assessed in 39 TN patients operated in the N. N. Burdenko National Medical Research Center for Neurosurgery during 2012–2014. Results: Psychic disturbances probability increased in direct proportion to the duration of the pain syndrome. Mental disorders in TN were significantly more likely to occur in psychopathically or characterologically accentuated individuals. The main psycho-emotional manifestations in patients before and after surgery for TN include varying degrees of emotional stress. A high degree of emotional stress was detected in 55 % of patients, moderate — in 35 %, mild — in 10 % of patients. During the follow-up study, it was found that the majority of patients defined their condition as good and satisfactory. Pain syndrome was not detected in 71 % of patients. The examination of the mental state in 71 % of cases did not reveal any changes, while in 14 % of cases the disorders were episodic.

Psychoemotional state and quality of life of nulliparous women with recurrent squamous epithelial exocervical dysplasia of the cervical epithelium in the perimenopausal period

The objective: to study the features of the psychoemotional state and quality of life of nulliparous women with recurrent squamous epithelial exocervical dysplasia of the cervical epithelium in the perimenopausal period.Materials and methods. 60 nulliparous women with recurrent cervical epithelial flat dysplasia that occurred after treatment with surgical methods in the perimenopausal period (the main group) and 38 women without gynecological and somatic pathologies in the perimenopausal period (control group) were examined. All patients were examined in accordance with the regulatory orders of the Ministry of Health of Ukraine. The assessment of neurovegetative and psychoemotional manifestations was carried out according to the Kupperman index, indicators of the quality of life and the Lusher color test.Results. The data of the medical history and clinical examination of patients were evaluated. This makes possible to identify a risk group among nulliparous women in the perimenopausal period for the development of recurrent squamous epithelial exocervical dysplasia of the cervical epithelium.In the main group, an increase in the Kupperman menopausal index by almost 1.5 times was found, as well as a significant decrease in indicators of psychosocial adaptation according to Lusher test to 40% and quality of life (physical component of health was 72.5±6.4 and 93,1±4,7 points in the main and control groups, respectively, mental component – 54.2±4.1 and 91,4±2,3 points, respectively).Conclusions. In infertile women with the menopausal changes, the recurrent squamous epithelial exocervical dysplasia of the cervical epithelium is a form of complicated course of dysplasia, and has a multifactorial genesis, in which conditions arise for the implementation of the neoplastic process. The clinical manifestations of the complicated course of the perimenopausal period significantly worsen the quality of life and general health in nulliparous women, especially on the background of recurrent squamous epithelial exocervical dysplasia of the cervical epithelium after surgical treatment, which is evidenced by more pronounced climacteric manifestations, reduction of physical and social activities, and emotional status.

The Mind-Body-Breath Link During Oral Intake in Chronic Obstructive Pulmonary Disease: A Grounded Theory Analysis.

Both chronic obstructive pulmonary disease (COPD) and dysphagia can be complicated by the shared physiological-psychoemotional manifestations of the conditions, such as anxiety and respiratory dysfunction. Despite their shared comorbidities, clinical research and management often focus on the isolated physiological impairments of each condition separately. Crucially, the oral intake experience of individuals with COPD-central for improved quality of life-remains underexplored. Thus, the purpose of this study was to understand the oral intake experience among individuals with COPD, including perceived barriers, behaviors, and emotions. Fourteen individuals with COPD (mean age 68.9; 7 females; 2 with diagnosed dysphagia) participated. Using grounded theory methodology, semi-structured interviews were conducted and analyzed. Four themes surfaced: (a) participants experience physiological manifestations of COPD (dyspnea, coughing) during eating/drinking; (b) emotions related to eating/drinking, such as concern, fear, anxiety, panic, and frustration stem from the physiological manifestations; (c) these emotions worsen the physiological manifestations; and (d) as a result of the physiological manifestations, they adapt eating/drinking behaviors (e.g., choose easier to eat foods, reduce intake size). The theory 'the mind-body-breath feedback and feedforward loops as a contributor to the oral intake experience in individuals with COPD' is subsequently proposed. Of clinical importance, many participants did not recognize their swallowing status as an issue. Ultimately, to promote patient-centered care, we need to view the oral intake experience for individuals with COPD through a more comprehensive lens that incorporates the interrelationships between the physiological and psychoemotional manifestations of COPD and better educate patients on COPD's impact on eating and drinking.

Effect of hysterectomy on the function of saved ovaries and correction of hormonal imbalance

The objective: to assess the hormonal disorders in patients after the radical treatment for leiomyoma and to develop the therapeutic options for correction.Materials and methods. The clinical and laboratory assessment of postoperative course after leiomyoma surgery in 160 women of reproductive age was carried out. The following groups of patients were formed: I group – 90 patients after vaginal hysterectomy (HE) with opportunistic salpingectomy and ovarian preservation, II group – 70 patients after abdominal HE with opportunistic salpingectomy and ovarian preservation. The control group included 50 women of reproductive age with asymptomatic leiomyoma.Then the following groups were formed to assess the effectiveness of the proposed medical correction program: the main group – 46 patients after vaginal HE with fallopian tubes and 36 persons after abdominal HE with fallopian tubes – received the proposed medical correction program, and the comparison group – 44 and 34 individuals after vaginal and abdominal HE with opportunistic salpingectomy and ovarian preservation, respectively, with standard approach for postoperative and rehabilitative periods.The diagnostic program included the assessment of hormonal level, post-hysterectomy syndrome degree by modified menopausal index using survey, urogenital and sexual dysfunction, and the indicators of vulvovaginal atrophy according to the Barlow scale.Results. Neurovegetative symptoms were observed in 36,7 % patients in the I group and 48.6 % - II group, vegetative-vascular symptoms – 46.7 % and 62.3 %, respectively. Insomnia was characterized by the sleep process disorders, the preservation of the feeling of fatigue after waking up. It is necessary to mention that an increase in the proportion of cardiovascular diseases up to 36 months after surgery (hypertension, dyshormonal cardiomyopathy and their combinations, 23.1 % were diagnosed with dyshormonal mastopathy, the women complained on arthralgia, morning joint stiffness, ostealgia twice more.The assessment of sexual disorders and manifestations of urogenital tract dysfunction allowed to indicate the most significant rate of dysuria complains in 72.9 % of cases in the II group after classical abdominal HE. Up to 36 months after surgery the subclinical hypothyroidism was found in 62.2 % of women in the I group and 31.4 % – II group, clinically significant hypothyroidism – in 21.1 % and 55.7 %, respectively.In the half of the cases the hormonal imbalance like hypoesrogenia was determined up to 36 months of monitoring without statistically significant differences between groups of different HE methodic. The main factor was patient’s age in which endocrine, vegetative-vascular disorders and the clinical manifestations of psychosomatic are developed in a larger percentage of significantly earlier in women of late reproductive age.The use of proposed program of therapeutic options after HE with ovarian preservation allowed to provide a tendency of the estradiol, progesterone and testosterone levels normalization, prolactin and cortisol concentrations were close to the reference values. Estradiol concentration in the women in main group increased, although it remained significantly below the age normal indices, and the most significant normalization of theses parameters were determined in women who received hormonal replacement therapy. Clinically positive effect in patients on the severity of neurovegetative and psychoemotional manifestations on the background of differentiated treatment was observed after 3 months from the beginning of therapy.Conclusions. The obtained results suggest that the optimization of the treatment program with the the proposed drugs in women in the groups leads to relative optimization of hormonal status and initiation of compensatory-adaptive responses of the organism, which improves the quality of life and eliminates symptoms of hypoestrogenism.

Characteristics of psycho-emotional manifestations and evaluation of the quality of life indicators in women with ovarian endometrioma combined with pelvic inflammatory diseases

The objective: an assessment of the psycho-emotional status and quality of life in women with endometrioid ovarian cysts combined with inflammatory diseases of the pelvic organs. Materials and methods. The study included 44 patients with endometrioid ovarian cysts combined with inflammatory processes of the pelvic organs (I group), and 46 women with isolated ovarian endometriosis (II group). The control group consisted of 30 patients without endometriosis and symptoms of chronic pelvic pain. The SF-36 questionnaire (The MOS 36-Item Short-Form Health Survey) was used to assess the quality of life, the level of depression and anxiety were determined by the Beck depression scale and the Spielberger–Khanin anxiety scale. Pain was assessed using a visual analogue scale. Results. The reasons for doctor’s visit were: menstrual irregularities (43.2% of patients in the I group and 34.8% – II group II), infertility (77.3% and 63.0%, respectively), miscarriage (13.6% and 8.7%), pain syndrome (up to 61.1% in general), as well as psycho-emotional and neurological conditions, urogenital disorders – cystalgia, irritable bowel syndrome, dysuria, frequent urination during menstruation, hematuria, dryness of the mucous membrane and dyspareunia. More than half of the women in the I group (56.8%) had severe pain combined with an expressed decrease in activity and transient disability, while in the II group only a quarter of the surveyed persons (23.9%) had pronounced manifestations of pelvic pain. The average level of depression in the II group was mild, while in the I group the parameters of moderate and mild depressive disorders were found in equal proportions. In the control group there were no manifestations of a depressive state. The indicators of trait anxiety and state anxiety scores in women in the I group were 52.12±12.26 and 49.84±8.29 points, respectively, in the II group – 40.12±10.22 and 44.26±6.24 points versus the data of the control group – 31.14±8.12 and 31.16±4.22 points (p<0.05). The results of the SF-36 questionnaire presented that the patients in the I group had lower quality of life parameters on the following scales: general health, physical functioning, the pain, dissatisfaction with the emotional state.Conclusions. In women with ovarian endometriosis combined with chronic pelvic inflammatory processes an increased level of anxiety and depression and significantly low indicators of all scales of the SF-36 questionnaire were determined.

Influence of Emotions on the Effectiveness of the Creative Process

The relevance of this study is determined by the importance of issues of interrelation of the emotional component of activity with the final results obtained in the course of creative research in different areas, as well as the practical significance of studying the problems of the influence of a wide range of emotional experiences on the overall effectiveness of the creative process. The purpose of this study is to determine the extent to which the emotional component of creativity influences the effectiveness of the creative process, regardless of the field of activity. The leading approach in this study was a combination of theoretical study of various aspects of creative activity in general, with a structural analysis of the features of the influence of the emotional component on the overall effectiveness of the creative process in various areas of activity. The results obtained in the course of this study demonstrate the wide range of possibilities for the rational use of personal emotional displays on the specific issues of applying creative activity in general and in terms of assessing the effectiveness of the creative process in particular. The results and conclusions of this paper have significant practical value for representatives of creative professions, researchers of psycho-emotional manifestations of personality in the conduct of creative activity, and will be useful for the next generations of researchers of various aspects of the influence of emotional experiences on the effectiveness of the creative process. The results will be useful as a scientific basis for the author to conduct further full-fledged research into the wide range of issues presented in this paper, thereby contributing to further objective and qualitative coverage of the subject matter

Menstrual Disorders and Main Indicators of Hormonal and Metabolic Homeostasis in Teenage Girls Against the Background of Endemic Goiter

Along with the widespread prevalence of goiter endemics, the medical and social significance of this problem is determined by the multifaceted spectrum of pathological abnormalities associated with asymptomatic course or hypothyroxinemia, causing numerous disorders at almost all stages of menstrual and reproductive function development.
 The objective of the research was to substantiate and conduct a comprehensive analysis of the prevalence, structure and leading factors of dishormonal disorders of menstrual function in adolescent girls with diffuse endemic goiter, and to develop a diagnostic algorithm based on the risk of the formation of this pathology.
 Materials and Methods. Two study groups were formed and a clinical laboratory examination was performed in 210 patients: 120 of them were diagnosed with menstrual dysfunction against the background of thyroid dysfunction (the main group); 60 girls were diagnosed with menstrual dysfunction and healthy thyroid gland (the comparison group); 30 apparently healthy girls made up the control group. Experimental and psychological methods, hormonal investigation of the level of thyroid, gonadotropic and steroid hormones, lipid and carbohydrate metabolism and vitamin D content in blood plasma were used.
 Results and Discussion. Hypomenstrual syndrome, secondary amenorrhea, dysmenorrhea, manifestations of premenstrual syndrome and anovulatory conditions are the main menstrual disorders in adolescents suffering from endemic goiter. One third of the girls in the main group had an increase in the proportion of delayed sexual development, while in the control group, physiological rates of sexual development occurred in 96.7% of observations. The presented hormonal studies made it possible to identify differentiated changes taking into account different clinical forms of menstrual disorders in this category of patients. The transition to the “mature” type of reproductive system functioning in girls with endemic goiter is associated with changes in prolactin secretion from low levels to the indicators that exceed the reference values, which is characterized by increased functional hyperprolactinemia. Generalization of the frequencies of the main psycho-emotional characteristics and indicators of the personal profile in the girls of the studied cohort allowed revealing the constant dominance of psycho-emotional manifestations of moderate degree, as well as high levels of psycho-emotional stress and depressive disorders against the background of dishormonal disorders and thyroid gland dysfunction. Obtained deviations of 25-hydroxyvitamin D level were noticed at the initial stages of thyroid disorder, and low 25-hydroxyvitamin D levels contributed to the manifestation of thyroid pathology.
 Conclusions. Dissociation of the thyroid system and the hypothalamic-pituitary-ovarian axis initiates menstrual disorders, development of functional cysts and multifollicular structure of the ovarian tissue, and, in case of hypothyroidism, is considered as a factor of metabolic disorders and polycystic ovary syndrome.

Нейроэнергетические корреляты психоэмоциональных феноменов (проявлений) климактерического синдрома

Introduction. Studying psychoneurophysiological correlates in perimenopausal women is of great theoretical and practical importance, since it may help in identifying common and gender-specific patterns of aging. The menopausal syndrome and the neurophysiological substrate underlying the phenomena of psychological maladjustment in menopausal women merit special attention. This study reveals previously unknown neuro-energetic correlates of psycho-emotional characteristics of the climacteric syndrome.
 Methods. This study involved menopausal women with and without manifestations of the menopausal syndrome and reproductive-age women with the normal menstrual cycle. Using the questioning method the authors examined the respondents’ personality traits. After averaging over groups, these personality characteristics were compared with the constant potential level (CPL) in frontal, central, occipital, right and left temporal regions of the cortex, which was registered by the Neuro-energo-cartograph NEC-5 hardware/software complex. The CPL was assessed by means of a special embedded math program. This helped to distinguish the local and the average CPLs, CPL gradients between unipolar values and to map the obtained data on the computer screen.
 Results. The findings of the study indicated a positive correlation between the expression of situational anxiety and unmotivated aggressiveness and the increased CPL in the occipital and temporal cortex in women with the climacteric syndrome.
 Discussion. For the first time in the study of the female climacterium, the use of registration and neuro-energetic mapping of the CPLs in various regions of the cerebral cortex and their correlations with psycho-emotional characteristics helped to identify the intensity and topography of energy metabolism in the brain, which is an integral neurophysiological substrate for psycho-emotional manifestations of the climacteric syndrome. The registration of the CPLs enabled authors to correlate the intensity and topography of energy metabolism in various regions of the cortex with psycho-emotional characteristics of the climacteric syndrome.

Застосування адаптивної фізичної культури у відновленні компенсаторних функцій хребта при остеохондрозі у осіб другого зрілого віку

The restoration of the compensatory functions of the spine in osteochondrosis in the elderly is a pressing issue in both medicine and physical rehabilitation. Almost half of the persons of the second period of mature age suffer from osteochondrosis of the spine, which leads to pain, muscle contractions, a decrease in the amplitude of movement, and the like. That is why the need for the application of special methods of physical rehabilitation to restore vital functions. Based on the analysis and synthesis of scientific medical literature and physical education and sports, an experimental technique has been developed to actively restore the spinal compensatory functions in osteochondrosis of the spine in the elderly. The method is based on the use of methods of adaptive physical culture as a set of measures, including exercise therapy and therapeutic massage. Spinal osteochondrosis is a degenerative process, in which there may be subluxations in the vertebral joints or slipping of the vertebrae is observed, as a result of which the spinal cord and its roots are injured. Use in the elderly, patients with osteochondrosis of the spine, experimental methods of active recovery of the compensatory functions of the spine gave a positive dynamic of functional changes. The experimental methodology is based on the application of adaptive physical culture methods as a set of measures that include exercise therapy and therapeutic massage. An experimental procedure for the active restoration of compensatory functions of the spine with osteochondrosis has been developed, which is based on: exercises for relaxation of the muscles of the upper extremities, shoulder girdle; unloading of the affected division of the spine; relaxation exercises; exercises for small and medium muscle groups; corrective exercises; breathing exercises static and dynamic. It is proved that taking special exercises, dispensing them, depending on the nature and clinical course of the disease, can purposefully affect and mainly change certain functions of the body by restoring damaged systems, adapting the patient to the physical load of domestic and industrial nature. Evaluation of the effectiveness of the method of active restoration of compensatory functions of the spine in osteochondrosis included the definition of appropriate criteria, which include: mobility of the intervertebral joints; the dynamics of pain syndrome; research of psychoemotional manifestations. The results of experimental studies have shown positive dynamics in the experimental group of the elderly, patients with spinal osteochondrosis, in connection with adaptation to physical activity and increase their motor activity. The testing of mental functions showed a positive effect of the experimental complex of exercises on the emotional state of patients.

AGE-RELATED CHANGES IN THE BEHAVIOR AND PHOBIC ANXIETY REACTIONS IN RATS UNDER EXPOSURE TO LIGHT DEPRIVATION AND LUZINDOLE

The effect of both long-term stay of rats under the specific extreme conditions of light deprivation, and the administration of a melatonin receptor antagonist luzindole on the agerelated pattern of behavioral reactions and psycho-emotional manifestations was studied. The level of the emotional and phobic anxiety state of the animals was assessed in an “Open field” installation in combination with the test “Dark chamber with holes”. We found that in the process of aging, rats kept in standard light conditions (LD) demonstrated a decline in motor activity along with an increase in phobic anxiety reactions. The effect of a prolonged exposure to light deprivation on the psycho-emotional state and motor activity of rats varied depending on the ontogenetic period during which the animals were placed in these specific conditions. At an advanced age, the anxiety level increased in rats kept in the dark since birth (LD/DD) to a greater degree than in the animals exposed to such conditions since prenatal development (DD/DD). The administration of a melatonin receptor antagonist luzindole to animals kept in constant darkness led to an age-related increase in phobic anxiety in the open space (as shown in the “Open Field” test), but had a normalizing effect on the psycho-emotional state of the rats in the “Dark chamber with holes” installation, imitating the animals’ natural shelter. It is concluded that the melatoninergic system, including the pineal gland, melatonin and its receptors, is directly involved in the regulation of the behavior and psycho-emotional state of rats under specific lighting conditions, which are often extreme and harmful for their health.

Особенности проявлений климактерического синдрома у женщин в постменопаузальный период в современных условиях

The objective: investigation was to study the expression of climacteric syndrome in postmenopausal women in Azerbaijan. Materials and methods.There were 120 postmenopausal women examined the average age of the women was 60.29±0.69 years. The duration of postmenopausal period was within 10.33±0.67 years. In 45 (37.5%) of women the duration of postmenopausal period varied between 2 and 5 years, 16 (13%) it was between 6 and 9 years, while in 59 (49.2%) of women it was more than 10 years. Results. As a result of the conducted studies, the frequency and severity of vegetative, metabolic-endocrine, psychoemotional manifestations of menopausal syndrome in the examined women in the postmenopausal period were determined. Conclusion. It was that autonomic nervous expressions of climacteric syndrome comprised 28.8±0.46, endocrine symptoms 22.6±0.8, emotional expressions were 7.8±4.6. The average evaluation of climacteric syndrome was 59.2±2.11, that corresponds to the moderate degree of expression of climacteric syndrome. Key words: postmenopausal period, autonomic nervous dystonia, endocrine symptoms, psycho emotional expressions, involutive process.