AbstractBackgroundEarly symptoms of Alzheimer’s disease may be identified by altered healthcare utilization patterns in the years preceding the diagnosis. Timely diagnosis is especially important for patients with young onset Alzheimer’s Disease (YOAD), who are often in the prime of their career and whose families may be financially dependent on the patient. The aim of this study was to identify changes in healthcare utilization in the prodromal phase of YOAD, and to identify any specific types of healthcare contacts with a more pronounced association than others.MethodWe conducted a retrospective density‐matched nested case‐control study. Cases were identified using the nationwide Danish Quality Database for Dementia and included everyone diagnosed with YOAD in a Danish memory clinic during 2016‐2018. Due to the often long time‐lag between symptom onset and diagnosis, patients aged <70 years at diagnosis were included. Age‐ and sex‐matched controls were drawn from a nationwide cohort of all Danish citizens. Healthcare utilization during 10 years prior to the diagnosis was assessed in the nationwide healthcare registries. Contact rate ratios (CRR) were calculated using negative binomial regression analysis adjusted for highest attained educational level at age 40 and civil status.ResultThe study included 1082 YOAD patients and 3246 age‐ and sex‐matched controls. In the year preceding diagnosis, we found increased CRRs for all but one type of contacts (private practice medical specialists). CRRs for all types of contacts with a general practitioner were significantly increased also >1‐5 years and >5‐10 years prior to diagnosis. The highest CRR was for psychiatric emergency admissions (8.96, 95% CI 4.45‐18.05) ≤1 year prior to diagnosis. In a sensitivity analysis, we found that those with moderate/severe dementia at time of diagnosis generally had higher CRRs and showed vulnerability earlier than those with mild cognitive impairment/mild dementia at time of diagnosis.ConclusionOur results demonstrate that YOAD patients have an altered pattern of healthcare utilization from as much as 5‐10 years prior to the diagnosis. Awareness of the specific alterations in help seeking behavior may help healthcare professionals provide a timely diagnosis.
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