Psoriasis In General Population Research Articles

Psoriasis: Epidemiology, clinical features, co-morbidities, and clinical scoring.

On the basis of current evidence derived from hospital-based studies, mostly from North India, the prevalence of psoriasis in adults varies from 0.44 to 2.8%, with a much lower prevalence in children. The peak age at onset in adults is in the third and fourth decade of life, with a slight male preponderance. It is recommended that population-based large epidemiologic studies should be undertaken in different parts of the country for estimating the correct prevalence of psoriasis in general population. Chronic plaque-type psoriasis is the most common morphologic presentation of psoriasis, accounting for more than 90% of all cases. Other morphologic variants that deserve special mention include palmoplantar psoriasis, pustular psoriasis, and recalcitrant psoriasis. For epidemiologic purposes, psoriasis can be classified into early and late onset psoriasis. Psoriasis can be classified on the basis of morphology and extent of involvement into localized and widespread disease. For the purpose of clinical trials, psoriasis may be classified as mild psoriasis, moderate psoriasis, and severe psoriasis. The literature shows that there is a significant risk of psoriatic arthritis (7–48%) in patients with plaque-type psoriasis. Hence, it is recommended to evaluate for its presence by detailed history taking and clinical examination, and if necessary, by appropriate radiological investigations. Evidence on the association between plaque-type psoriasis and cardiovascular disease risk factors and ischemic heart disease isinconsistent. On the basis ofavailable evidence, it is prudent to proactively look for metabolic syndrome, dyslipidemia, and obesity, especially in patientswith severe psoriasis (Level 1+ evidence based on systematic reviews and meta-analysis). Based on the current evidence, the psoriasis area severity index appears to be the most valid and reproducible clinical severity score in the management of adult patients with plaque-type psoriasis.

Severity of Psoriasis and Body Mass Index: The Cut off are Overweight Patients rather Than Obese Ones

Background: Obesity has been found to be associated with an increased risk of psoriasis in general population. However, studies addressing the relationship between obesity and clinical severity of psoriasis are still scarce and confused. Objective: In this study, we investigated the relationship between levels of overweight and the clinical severity of psoriasis in Caucasian patients. Methods: This study involved a total of 300 patients with chronic plaque psoriasis. Their body mass index (BMI) was calculated as weight in kilograms divided by height in squared metres and was categorized into four groups (BMI 30, overweight; BMI >30, obesity). Disease severity was assessed by Psoriasis Area and Severity Index. Results: The correlation between PASI score and BMI was statistically significant between overweight and normoweight patients.

VIH y psoriasis en un minero de Colombia

The incidence of psoriasis in general population ranges from 1 to 2%, similar to that found in patients with HIV, who despite having a diminished Th1 response, are affected by a more severe form of the psoriatic disease and more refractory to conventional treatments.We present the case of a patient with HIV and severe skin lesions, compromising most of the body surface. After receiving a methotrexate therapy, started due the extensive cutaneous involvement, an improvement of the lesions was evidenced. It should be noted that the presentation of skin diseases varies in the different states of immunosuppression, and likewise, the proposed treatment must be the one that does not worsen their condition and does not interact with antiretroviral drugs.

Relationships between obesity and the clinical severity of psoriasis in Taiwan

Obesity has been found to be associated with an increased risk of psoriasis in general population. However, studies addressing the relationship between obesity and clinical severity of psoriasis are still scarce, especially in Asian people. In this study, we investigated the relationship between levels of obesity and the clinical severity of psoriasis in Taiwanese psoriasis patients. This was a hospital-based cross-sectional study. A total of 399 patients with chronic plaque psoriasis were recruited. Their body mass index (BMI) was calculated as weight in kilograms divided by height in metres squared and was categorized into four groups (BMI < 24, normal; 24 <or= BMI < 27, overweight; 27 <or= BMI < 30, mild obesity; and BMI >or= 30, moderate-to-severe obesity). Disease severity was assessed by Psoriasis Area and Severity Index. Cumulative logistic regression models were used to estimate the association between BMI and Psoriasis Area and Severity Index. After adjusting for potential confounders (age, gender, cigarette smoking and duration of disease), moderate-to-severe obesity was significantly associated with an increased risk of clinically more severe psoriasis when compared with normal BMI [odds ratio, 2.70; 95% confidence interval,1.42-5.11]. There is a significant linear trend for clinically more severe psoriasis across increasing of BMI categories (P for trend = 0.004). The effect of obesity on the severity of psoriasis was greater in men than in women (test for interaction, P = 0.03). In psoriasis patients, obesity is associated with a more severe disease, especially in men. Bodyweight control may be important for the management of psoriasis.

Mapping the future of common diseases: lessons from psoriasis

Psoriasis (OMIM*177900) is a common, chronic, hyperproliferative inflammatory disorder of the skin affecting approximately 2% of Caucasians. Despite the prevalence of psoriasis in general population, significant differences in the incidence among Japanese, Eskimos, West Africans, north American blacks and American natives are well known. The cause for these variations are likely to be both genetic and environmental. Independent genomewide scans have suggested the involvement of a large number of chromosomal regions (loci), but so far only poor susceptibility genes have been suggested. We discuss genetic basis of the disease, results and interpretations of relevant studies, with particular regard to study design and future perspectives. Indeed to date, mapping genes which contribute to complex diseases is one of the major challenge in the post-genomic era.

Some features in the cases of psoriasis seen in Gaziantep province

Psoriasis is a chronic and recurrent inflammatory dermatosis with variable clinical courses. lts frequency varies in different populations according to geographical areas, races, and age groups. Determination of the true prevalence rate of psoriasis in general population is rather difficult and is thought to constitute 1-3% of all dermatoses. The frequency of psoriasis has been investigated in various regions of our country, but no epidemiologic study on psoriasis has been done previously in Gaziantep province. Our aim was to find the frequency of psoriasis among skin diseases and to investigate other epidemiologic features of the patients with psoriasis. We studied retrospectively the frequency of psoriasis in 39087 patients that had referred to our clinic between 1990 and 1999, and the distribution of cases in age groups, gender, and seasons. Disease types and treatment modalities were also recorded. Psoriasis was diagnosed in 1105 patients, giving a frequency rate of 2.82%. Of those, 545 were women (49.32%) and 560 were men (50.68%) ( p&gt;0.05). Mean age (± SD) of the cases was 30.66±18.32. Twenty-two per cent of cases (n: 244) was in the third decade, and 20.54% (n: 227) in the second decade. Thirty-five percent of the cases had been referred during the winter months, and 25.88% in spring; the rates were found to be significantly higher than those in !he other seasons (p&lt;0.0001, and p&lt;0.01, respectively). The most commonly seen psoriasis type was vulgar (77.1%) followed by guttate 6.78 %, pustular (2.44%), erythrodermic (0.81%) and arthropatic (0.54%). Psoriasis was restricted only to palms and soles in 5.06%, to scalp in 4.52%, to flexural areas in % 1.62, and to nails in 1.08% of the cases. Topical therapies had been used in 86.24%, UVB in 6.87%, UVA and RePUVA in 4.07%, methotrexate in 0.63% of the patients. Results are discussed in comparison with the literature data.