Pseudolymphoma Research Articles

Differentiation between malignant B-cell lymphomas and pseudolymphomas of the skin.

Among cutaneous pseudolymphomas (PL) in a strict sense, in which the etiology is largely unknown, B-cell types, simulating malignant B-cell lymphoma, and T-cell types, simulating malignant T-cell lymphoma of the skin, can be differentiated. Criteria favoring a pseudolymphomatous rather than a malignant lymphoid infiltrate of B-cell type may be clinical (solitary lesion on the head), histologic (wedge-shaped infiltrate with follicle formation and sharply demarcated germinal centers), or cytomorphologic (polymorphous infiltrate showing an admixture of great numbers of macrophages, plasma cells, and eosinophils). Additional information can be provided by enzymophenotyping of the cells, showing the typical starry-sky pattern of the macrophages in pseudolymphomatous infiltrates, and by the demonstration of the polyclonality of the lymphoid cells in pseudolymphomas with respect to surface markers and intracytoplasmatic Ig production, as shown by immunophenotyping techniques.

The Histopathology of Lymphomas and Pseudolymphomas

The Histopathology of Lymphomas and Pseudolymphomas

Lymphoid interstitial pneumonia with monoclonal gammopathy.

Saltzstein (1) has given a good account of the pseudolymphomas and malignant lymphomas of the lung. He suggested that in some instances histologic distinction between those two entities is not possible. As far as could be determined the association of pulmonary pseudolymphom~ and myasthenia gravis has not been reported previously. This association, accompanied by dysimmunoglobulinemia, was observed in the case that is now presented.