Pruritus is a common symptom that can significantly reduce quality of life often through sleep disruption. We sought to investigate the features of disturbed sleep in patients with chronic pruritic dermatoses and test the hypothesis that increased systemic inflammation may serve as a biomarker for impaired sleep in these patients. We conducted a cross-sectional analysis of the National Health and Nutrition Examination Survey data. Odds ratios (OR), 95% confidence intervals (95%CI), and p-values using logistic regression were calculated weighted to the US Census data. Model 1 was adjusted for demographic factors (sex, age, race, education, marital status, income) while model 2 was adjusted for medical comorbidities (age, sex, allergy history, heart disease, body mass index). Chronic pruritic dermatoses were associated with waking up during the night (Model 1: OR=1.646, 95%CI [1.031-2.627], p=0.038; Model 2: OR=1.329, 95%CI [0.888-1.989], p=0.031), waking up too early in the morning (Model 1: OR=1.669, 95%CI [1.118-2.493], p=0.016 ; Model 2: OR=1.582, 95%CI [1.008-2.481], p=0.046), feeling overly sleepy during the day (Model 1: OR=1.786, 95%CI [1.144-2.789], p=0.014; Model 2: OR=1.664 , 95%CI [1.073-2.581], p=0.026), and not getting enough sleep (Model 1: OR=1.603 , 95%CI [1.049-2.450], p=0.032; Model 2: OR=1.598, 95%CI [1.064-2.399], p=0.027). Mean C-reactive protein (CRP) levels were 52.8% higher among pruritic dermatoses patients reporting trouble sleeping compared to those who did not (0.663 vs 0.434 mg/dL; p=0.034). Pruritic dermatoses were also positively correlated with CRP levels with a β coefficient of 0.142 (p=0.025). In addition to confirming sleep disturbances with pruritic dermatoses, we found that sleep disturbances are more likely to present with elevated CRP levels. Thus, clinicians should consider the potential risk for sleep-related and cardiac comorbidities in patients diagnosed with itchy skin conditions.