A molecular genetic analysis of genomes of porcine reproductive respiratory syndrome virus (PRRSV) and porcine circovirus type 2 (PCV-2) circulating in the territory of the Russian Federation is given. The results of the study showed the presence of circulation of European genotypes of PRRSV strains that are similar to isolates found in France and Denmark from 1998 to 2001. We explained the homology of a fragment of one of the genes between the Russian isolates and the vaccine strain used in Porcilis PRRS (Intervet) vaccine, but this requires further study. Strains of the North American genotype of PRRS were not found. The PCV-2 genomes fall into three separate groups. One (genotype 2b) is formed by isolates in Malaysia, Brazil, Switzerland, China, Slovakia, the United Kingdom, and the United States, which were isolated during the period from 2004 to the present time. The second group consists of the field sequences of viruses isolated in 2000–2012 in Canada, the United States, China, and South Korea (genotype 2a). The third group is formed by highly pathogenic isolates evolved in 2013 in China (genotype 2c). The circulation of all three known genotypes of PCV-2-2a, 2b, and 2c-in the Russian Federation was shown.