Introduction: The informed consent process delays or results in a refusal of therapy in up to 10% of eligible patients. Our prior work identified preferences, content, framing, sequencing of the informed consent process for tPA based on patient, physician, caregiver, and layperson input. These data were used by design teams in an iterative process with both patients and clinicians through an AHRQ-funded project to develop patient-facing decision aids ( S tandardized C onsent R edesign and I mplementation P rotocol for t PA in S troke: SCRIPtS). Hypothesis: We hypothesized that the SCRIPtS intervention would improve patient knowledge, and reduce decisional conflict and regret without impacting door to needle (DTN) time. Methods: Patients or their proxies who provided informed consent for tPA at a single academic medical center were approached from July 1, 2017 to June 30, 2019. All neurology residents who obtain informed consent for tPA were trained on the SCRIPtS intervention on July 2, 2018. Prospective data captured included: DTN time and qualitative data in the form of: patient or proxy decisional conflict (6-items) within 48h of tPA treatment, and patient or proxy decision regret (5-items) at 14 days and 90 days post-treatment. Mann-Whitney U and t-test statistics were used to compare pre-intervention (before July 2, 2018) to post-intervention results. Internal consistency of survey responses was measured using Cronbach’s α. Results: During pre-intervention, 32 patients received tPA with a median DTN of 41.7m ( + 8.8). Twenty patients received tPA post-intervention with a median DTN of 48.0m (+/- 16.3, p=0.11). Eight (63% female, 25% black) pre- and 14 (57% female, 36% black) post-SCRIPtS stroke patients or their proxies provided qualitative data. We observed a significant improvement in patient reported understanding of the side effects of tPA post-SCRIPtS (3.25 + 0.54 vs 4.14 + 0.14; p=0.02). There was no difference in measures of decisional conflict or of decision regret between groups (Cronbach’s α = 0.75). Conclusions: The small pilot study suggests that an intervention to improve patient and family understanding of risks and benefits of tPA can be successfully implemented without prolonging DTN time.