The vortex-induced vibration and solid-structure impact of a neutrally buoyant horizontal flexible pipe in the vicinity of a bottom wall boundary are experimentally investigated in a water flume. The pipe with an aspect ratio of 87 is arranged with an oblique angle of 30° and an initial gap-to-diameter ratio of 0.5. A non-intrusive measurement with two high-speed cameras is employed to simultaneously capture the spatial-temporal vibration displacements in both inline and crossflow directions, and the pipe-wall impact process in the reduced normal velocity range of 3.40–14.43 with a maximum Reynolds number of 2780. Experimental results highlight the new pipe equilibrium profiles deviating away from the bottom boundary due to the wall proximity and wall collision. The occurrence of wall-impact is determined by whether the crossflow amplitude is larger or equal to the summation of the new equilibrium position and initial gap. The observed five distinct solid-pipe impact patterns as well as the location and length of the impacting segments are closely associated with the dominant response mode and the space-varying response amplitude. Particularly, the response mode competition contributes to the spatial shift of impacting position over time.