Oases, serving as ideal locations for human settlements in arid regions, exhibit extreme sensitivity to regional climatic fluctuations. Consequently, the oasis deposition sediments play a pivotal role in the study of regional paleoenvironmental changes and the exploration of prehistoric human-environment interactions. The YSD and STM sections, both typical aeolian-lacustrine sections located at the edge of the Tarim Basin, were investigated in this study. By analyzing optically stimulated luminescence (OSL) dating results and grain-size proxy indicators, the environmental evolution patterns in the Tarim Basin since approximately 2.2 ka BP were reconstructed. Additionally, the parametric end-member analysis on the grain-size data was conducted to explore the environmental significance revealed by each end-member. The research findings indicate that: (1) ∼ 2.2–1.8 ka B.P., sediment morphology and grain-size parameters indicate that the climate in the Tarim Basin recorded by the STM section was relatively dry, with rivers gradually receding and frequent sand-drift activities. During the development of the YSD section (∼1.67–1.5 ka B.P.), the environmental conditions in the Tarim Basin transitioned to a relatively humid phase, with the Yarkand River experienced multiple episodes of natural diluvial deposition. The grain-size data of two sections both comprise five sedimentary dynamic components, serving as sensitive indicators of regional humidity conditions and winter monsoon intensity. (2) The oasis development in the Tarim Basin during the late Holocene (particularly refers to between ∼ 2.2 ka B.P. and ∼ 1.4 ka B.P.) exhibits a significant positive correlation with temperature records. (3) Environmental changes and human activities jointly regulate the spatial and temporal distribution and number of archeological sites during the development of both sections. However, the dominance of the two factors varied across different historical periods.