This research project analyses the impact of the use of prototyping and digital manufacturing tools in the development of new products based on the theme of Gonçalo’s basketwork, in Guarda, Portugal [1]. Guarda Ninhos is an inclusive entrepreneurship project, the aim of which was to develop, produce and promote new local handicraft products. Solutions based on the socio-cultural, ecological and economic heritage of this region, knowledge immaterial heritage and expertise of their communities. Reinventing the culture of this place as a way of creating social and economic value, with the people who live there, was the followed line of action. Based on the results obtained, an attempt was made to outline forms of cooperation between this type of artisanal activities, with the most recent concepts of “industry 4.0” and industrial development methodologies - namely, (A) verifying the beneficial impact that the use of prototyping and digital fabrication tools can play in the design process of these products, optimising the development and production processes without jeopardising the premises that define the artisanal product; (B) contributing to the registration of ancestral knowledge and consolidation of artisanal processes and (C) showing how a strategic plan that aims to bring together and sustain the interdisciplinary artisan-designer relationship can be implemented.