Proton Irradiation Research Articles

SAPPHIRE —establishment of small animal proton and photon image-guided radiation experiments

The in vivo evolution of radiotherapy necessitates innovative platforms for preclinical investigation, bridging the gap between bench research and clinical applications. Understanding the nuances of radiation response, specifically tailored to proton and photon therapies, is critical for optimizing treatment outcomes. Within this context, preclinical in vivo experimental setups incorporating image guidance for both photon and proton therapies are pivotal, enabling the translation of findings from small animal models to clinical settings. The SAPPHIRE project represents a milestone in this pursuit, presenting the installation of the small animal radiation therapy integrated beamline (SmART+ IB, Precision X-Ray Inc., Madison, Connecticut, USA) designed for preclinical image-guided proton and photon therapy experiments at University Proton Therapy Dresden. Through Monte Carlo simulations, low-dose on-site cone beam computed tomography imaging and quality assurance alignment protocols, the project ensures the safe and precise application of radiation, crucial for replicating clinical scenarios in small animal models. The creation of Hounsfield lookup tables and comprehensive proton and photon beam characterizations within this system enable accurate dose calculations, allowing for targeted and controlled comparison experiments. By integrating these capabilities, SAPPHIRE bridges preclinical investigations and potential clinical applications, offering a platform for translational radiobiology research and cancer therapy advancements.

Reliability evaluation of spacecraft power generation performance with competitive failure processes under irradiation

AbstractThe performance of space power systems is crucial for space products as it determines the operational capabilities, endurance, and efficiency of satellites, spacecraft, and other extraterrestrial devices. Unlike reliability analysis in aerospace systems, studying spacecraft power generation performance requires consideration of both hardware and software aspects. Existing failure models do not fully capture the self‐recovery process of control programs. Therefore, this study presents an impact degradation model for space power systems that incorporates competitive failures under irradiation conditions. The model analyzes solar arrays and power controllers to derive a performance degradation model by considering the defect formation mechanism of amorphous semiconductor materials. Additionally, two shock types are defined based on redundancy backup in power controllers and scrubbing frequency in field‐programmable gate array (FPGA) units. Within the case analysis section, the research meticulously investigates and elucidates the correlation probabilities among varying proton irradiation doses, scrubbing frequencies, and the aforementioned shock types.

Positron annihilation spectroscopy evaluation of using proton irradiation as a surrogate for early neutron radiation damage

A positron annihilation spectroscopy investigation of early stages of radiation-induced damage in Chinese f/m (ferritic/martensitic) steel SIMP and strengthened variant of f/m steel ODS (oxide dispersion strengthened) EUROFER was conducted. Studied materials were irradiated by neutrons at the LVR-15 research reactor to 0.12 dpa at an average temperature of 260 ± 20 °C, and implanted by protons at the 6 MV Tandetron Accelerator of the Slovak University of Technology, to 0.0196 dpa at room temperature (RT) and 300 °C. The potential of using proton irradiation as a surrogate for early neutron radiation damage was investigated. A lifetime spectrometer and Doppler spectrometer was used to obtain simultaneously positron lifetime (PALS) and Doppler broadening spectra (DBS), which provided experimental data used to characterize the vacancy-type defect and their interaction with H atoms in the studied materials. The obtained results show an increase of mean positron lifetime (MLT) in the proton-implanted samples at RT when compared with high temperature irradiation. Similar trend was observed when comparing vacancy concentration of different irradiation conditions. The impact of temperature on mobility and recombination of defects, as well as effect of vacancy stabilization by H atoms, has been addressed. The effect of ODS microstructure on results has been examined. A methodology of comparing various irradiation conditions has been proposed, where the vacancy concentrations have been normalized by the dpa values. The potential application of proton implantation for evaluation of early stages of neutron damage was found to be promising.

Self-Healing Transparent Poly(dimethyl)siloxane with Tunable Mechanical Properties: Toward Enhanced Aging Materials for Space Applications.

When exposed to the geostationary orbit, polymeric materials tend to degrade on their surface due to the appearance of cracks. Implementing the self-healing concept in polymers going to space is a new approach to enhancing the lifespan of materials that cannot be replaced once launched. In this study, the elaboration of autonomous self-healing transparent poly(dimethylsiloxane) (PDMS) materials resistant to proton particles is presented. The PDMS materials are functionalized with various compositions of urea and imine moieties, forming dynamic covalent and/or supramolecular networks. The hydrogen bonds induced by the urea ensure the formation of a supramolecular network, while the dynamic covalent imine bonds are capable of undergoing exchange reactions. Materials with a broad range of mechanical properties were obtained depending on the composition and structure of the PDMS networks. As coating applications in a spatial environment were mainly targeted, the surface properties of the polymer are essential. Thus, percentages of scratch recovery were determined by AFM. From these data, self-healing kinetics were extracted and rationalized based on the polymer structures. The obtained data were in good agreement with the relaxation times determined by rheology in stress relaxation experiments. Moreover, the accelerated aging of materials under proton irradiation, simulating a major part of the geostationary environment, revealed a strong limitation or disappearance of cracks while keeping the transparency of the PDMS. These promising results open routes to prepare new flexible autonomous polymeric materials for space applications.

Impact on the Transcriptome of Proton Beam Irradiation Targeted at Healthy Cardiac Tissue of Mice.

Proton beam therapy is considered a step forward with respect to electromagnetic radiation, thanks to the reduction in the dose delivered. Among unwanted effects to healthy tissue, cardiovascular complications are a known long-term radiotherapy complication. The transcriptional response of cardiac tissue from xenografted BALB/c nude mice obtained at 3 and 10 days after proton irradiation covering both the tumor region and the underlying healthy tissue was analyzed as a function of dose and time. Three doses were used: 2 Gy, 6 Gy, and 9 Gy. The intermediate dose had caused the greatest impact at 3 days after irradiation: at 2 Gy, 219 genes were differently expressed, many of them represented by zinc finger proteins; at 6 Gy, there were 1109, with a predominance of genes involved in energy metabolism and responses to stimuli; and at 9 Gy, there were 105, mainly represented by zinc finger proteins and molecules involved in the regulation of cardiac function. After 10 days, no significant effects were detected, suggesting that cellular repair mechanisms had defused the potential alterations in gene expression. The nonlinear dose-response curve indicates a need to update the models built on photons to improve accuracy in health risk prediction. Our data also suggest a possible role for zinc finger protein genes as markers of proton therapy efficacy.

Comparing the effects of irradiation with protons or photons on neonatal mouse brain: Apoptosis, oncogenesis and hippocampal alterations

Background and PurposeMedulloblastoma (MB) is a common primary brain cancer in children. Proton therapy in pediatric MB is intensively studied and widely adopted. Compared to photon, proton radiations offer potential for reduced toxicity due to the characteristic Bragg Peak at the end of their path in tissue. The aim of this study was to compare the effects of irradiation with the same dose of protons or photons in Patched1 heterozygous knockout mice, a murine model predisposed to cancer and non-cancer radiogenic pathologies, including MB and lens opacity. Materials and MethodsTOP-IMPLART is a pulsed linear proton accelerator for proton therapy applications. We compared the long-term health effects of 3 Gy of protons or photons in neonatal mice exposed at postnatal day 2, during a peculiarly susceptible developmental phase of the cerebellum, lens, and hippocampus, to genotoxic stress. ResultsExperimental testing of the 5 mm Spread-Out Bragg Peak (SOBP) proton beam, through evaluation of apoptotic response, confirmed that both cerebellum and hippocampus were within the SOBP irradiation field. While no differences in MB induction were observed after irradiation with protons or photons, lens opacity examination confirmed sparing of the lens after proton exposure. Marked differences in expression of neurogenesis-related genes and in neuroinflammation, but not in hippocampal neurogenesis, were observed after irradiation of wild-type mice with both radiation types.Conclusion.In-vivo experiments with radiosensitive mouse models improve our mechanistic understanding of the dependence of brain damage on radiation quality, thus having important implications in translational research.

Secondary neutron dosimetry for conformal FLASH proton therapy.

Cyclotron-based proton therapy systems utilize the highest proton energies to achieve an ultra-high dose rate (UHDR) for FLASH radiotherapy. The deep-penetrating range associated with this high energy can be modulated by inserting a uniform plate of proton-stopping material, known as a range shifter, in the beam path at the nozzle to bring the Bragg peak within the target while ensuring high proton transport efficiency for UHDR. Aluminum has been recently proposed as a range shifter material mainly due to its high compactness and its mechanical properties. A possible drawback lies in the fact that aluminum has a larger cross-sectionof producing secondary neutrons compared to conventional plastic range shifters. Accordingly, an increase in secondary neutron contamination was expected during the delivery of range-modulated FLASH proton therapy, potentially heightening neutron-induced carcinogenic risks to thepatient. We conducted neutron dosimetry using simulations and measurements to evaluate excess dose due to neutron exposure during UHDR proton irradiation with aluminum range shifters compared to plastic rangeshifters. Monte Carlo simulations in TOPAS were performed to investigate the secondary neutron production characteristics with aluminum range shifter during 225MeV single-spot proton irradiation. The computational results were validated against measurements with a pair of ionization chambers in an out-of-field region ( 30cm) and with a Proton Recoil Scintillator-Los Alamos rem meter in a far-out-of-field region (0.5-2.5m). The assessments were repeated with solid water slabs as a surrogate for the conventional range shifter material to evaluate the impact of aluminum on neutron yield. The results were compared with the International Electrotechnical Commission (IEC) standards to evaluate the clinical acceptance of the secondary neutronyield. For a range modulation up to 26cm in water, the maximum simulated and measured values of out-of-field secondary neutron dose equivalent per therapeutic dose with aluminum range shifter were found to be and , respectively, overall higher than the solid water cases (simulation: ; measurement: ). The maximum far out-of-field secondary neutron dose equivalent was found to be ( ) and ( ) for the simulations and rem meter measurements, respectively, also higher than the solid water counterparts (simulation: ( ) ; measurement: ( ) ). We conducted simulations and measurements of secondary neutron production under proton irradiation at FLASH energy with range shifters. We found that the secondary neutron yield increased when using aluminum range shifters compared to conventional materials while remaining well below the non-primary radiation limit constrained by the IECregulations.

Study of head and neck squamous cell carcinoma transcriptome after proton therapy

Aim. To evaluate changes in the transcriptome of head and neck squamous cell carcinoma (HNSCC) tissue cells in patients after proton therapy.Materials and methods. Biopsy material obtained from 3 HNSCC patients before and after proton therapy at a total dose of 10 isoGy was homogenized, purified, and concentrated. Then total RNA was isolated with further purification and concentration with the RNA Clean & Concentrator kit (Zymo Research). Library quantitation was assessed using the Qubit 2.0 instrument (Invitrogen, Life Technologies). After isolation of 1 μg total RNA for sequencing, libraries were prepared on the Illumina platform using the TruSeq RNA Sample Prep Kit v2 with a 10-cycle enrichment step according to the manufacturer’s recommendations. The quality of RNA and the resulting libraries was checked using the Agilent 2100 Bioanalyzer system (Agilent Tec. Inc., USA). The RIN parameter for RNA was at least 7. The library concentration was assessed by real-time PCR on the CFX96 Touch Real-Time PCR Detection System (Bio-Rad, USA). Final libraries were pooled in equimolar ratios before sequencing on the Illumina HiSeq 2500 platform using 50 base-pair paired-end reads. The Q20 parameter for all samples was > 97%, and the number of reads averaged 60.2 million per sample. Raw reads were processed using the RTA 1.17.21.3 and Casava 1.8.2 (Illumina). The enrichment analysis was performed using the PANTHER 17.0 software.Results. The transcriptome analysis of HNSCC after proton radiation therapy (5 x 2 isoGy) at a total dose of 10 isoGy revealed 1,414 significantly differentially expressed genes. The 10 most and least expressed genes and their associated signaling pathways were identified. A number of signaling pathways associated with the underexpressed genes were detected in HNSCC after proton therapy, such as: STAT5; PD-1 signaling pathway; marked MET-mediated activation of PTK2 signaling pathway, PDGF signaling; CD22-mediated regulation of BCR; and FCERI-mediated MAPK activation. In addition to the above signaling pathways, activation of collagen degradation, FCGR3A-mediated phagocytosis, and FCGR3A-mediated interleukin (IL)-10 synthesis are of interest. In the enrichment analysis among highly expressed genes, keratinization and biological oxidation processes were activated in HNSCC tissues after proton therapy.Conclusion. Proton therapy in HNSCC leads to overexpression of genes involved in the regulation of keratinization and biological oxidation processes as well as to underexpression of genes associated with suppression of signaling pathways: STAT5, PD-1, MET-mediated activation of PTK2 signaling pathway, PDGF signaling; CD22-mediated regulation of BCR; FCERI-mediated MAPK activation, collagen degradation, FCGR3A-mediated phagocytosis activation, and FCGR3A-mediated IL-10 synthesis. All signaling pathways of underexpressed genes function in HNSCC cells if there is no negative influence on the tumor from outside (irradiation or delivery of antitumor drugs). The predominance of suppressed signaling pathways over activated ones most likely indicates a decrease in the functional potential of cells after proton therapy. The dose-dependence of PT effects necessitates further study of changes in cellular and molecular-genetic signatures of HNSCC after proton irradiation with different doses.

Predicting the risk of neurocognitive decline after brain irradiation in adult patients with a primary brain tumor.

Deterioration of neurocognitive function in adult patients with a primary brain tumor is the most concerning side effect of radiotherapy. This study was aimed to develop and evaluate Normal-Tissue Complication Probability (NTCP) models using clinical and dose-volume measures for 6-month, 1-year and 2-year Neurocognitive Decline (ND) post-radiotherapy. A total of 219 patients with a primary brain tumor treated with radical photon and/or proton radiotherapy (RT) between 2019 and 2022 were included. Controlled Oral Word Association (COWA) test, Hopkins Verbal Learning Test-Revised (HVLTR) and Trail Making Test (TMT) were used to objectively measure ND. A comprehensive set of potential clinical and dose-volume measures on several brain structures were considered for statistical modelling. Clinical, dose-volume and combined models were constructed and internally tested in terms of discrimination (Area Under the Curve, AUC), calibration (Mean Absolute Error, MAE) and net benefit. 50%, 44.5% and 42.7% of the patients developed ND at 6-month, 1-year and 2-year timepoints, respectively. Following predictors were included in the combined model for 6-month ND: age at radiotherapy>56 years (OR=5.71), overweight (OR=0.49), obesity (OR=0.35), chemotherapy (OR=2.23), brain V20Gy≥20% (OR=3.53), brainstem volume≥26cc (OR=0.39) and hypothalamus volume≥0.5cc (OR=0.4). Decision curve analysis showed that the combined models had the highest net benefits at 6-month (AUC=0.79, MAE=0.021), 1-year (AUC=0.72, MAE=0.027) and 2-year (AUC=0.69, MAE=0.038) timepoints. The proposed NTCP models use easy-to-obtain predictors to identify patients at high-risk of ND after brain RT. These models can potentially provide a base for RT-related decisions and post-therapy neurocognitive rehabilitation interventions.

Proton FLASH radiotherapy ameliorates radiation-induced salivary gland dysfunction and oral mucositis and increases survival in a mouse model of head and neck cancer.

Head and neck cancer radiotherapy often damages salivary glands and oral mucosa, severely negatively impacting patients' quality of life. The ability of FLASH- Proton Radiation therapy (F-PRT) to decrease normal tissue toxicity while maintaining tumor control compared to Standard Proton Radiation therapy (S-PRT) has been previously demonstrated for several tissues. However, its potential in ameliorating radiation-induced salivary gland dysfunction and oral mucositis and controlling orthotopic head and neck tumor growth has not been reported. The head and neck area of C57BL/6 mice was irradiated with a single dose of RT (ranging from 14-18 Gy) or a fractionated dose of 8 Gy x 3 of F-PRT (128 Gy/s) or S-PRT (0.95 Gy/s). Following irradiation, the mice were studied for radiation-induced xerostomia by measuring their salivary flow. Oral mucositis was analyzed by histopathological examination. To determine the ability of F-PRT to control orthotopic head and neck tumors, tongue tumors were generated in the mice and then irradiated with either F-PRT or S-PRT. Mice treated with either a single dose or fractionated dose of F-PRT showed significantly improved survival than those irradiated with S-PRT. F-PRT-treated mice showed improvement in their salivary flow. S-PRT-irradiated mice demonstrated increased fibrosis in their tongue epithelium. F-PRT significantly increased the overall survival of the mice with orthotopic tumors compared to the S-PRT-treated mice. The demonstration that F-PRT decreases radiation-induced normal tissue toxicity without compromising tumor control, suggests that this modality could be useful for the clinical management of head and neck cancer patients.

Evaluation of specific RBE in different cells of hippocampus under high-dose proton irradiation in rats.

The study aimed to determine the specific relative biological effectiveness (RBE) of various cells in the hippocampus following proton irradiation. Sixty Sprague-Dawley rats were randomly allocated to 5 groups receiving 20 or 30Gy of proton or photon irradiation. Pathomorphological neuronal damage in the hippocampus was assessed using Hematoxylin-eosin (HE) staining. The expression level of NeuN, Nestin, Caspase-3, Olig2, CD68 and CD45 were determined by immunohistochemistry (IHC). The RBE range established by comparing the effects of proton and photon irradiation at equivalent biological outcomes. Proton20Gy induced more severe damage to neurons than photon20Gy, but showed no difference compared to photon30Gy. The RBE of neuron was determined to be 1.65. Similarly, both proton20Gy and proton30Gy resulted in more inhibition of oligodendrocytes and activation of microglia in the hippocampal regions than photon20Gy and photon30Gy. However, the expression of Olig2 was higher and CD68 was lower in the proton20Gy group than in the photon30Gy group. The RBE of oligodendrocyte and microglia was estimated to be between 1.1 to 1.65. For neural stem cells (NSCs) and immune cells, there were no significant difference in the expression of Nestin and CD45 between proton and photon irradiation (both 20 and 30Gy). Therefore, the RBE for NSCs and immune cell was determined to be 1.1. These findings highlight the varying RBE values of different cells in the hippocampus in vivo. Moreover, the actual RBE of the hippocampus may be higher than 1.1, suggesting that using as RBE value of 1.1 in clinical practice may underestimate the toxicities induced by proton radiation.

Comprehensive radiotherapy for pediatric Ewing Sarcoma: Outcomes of a prospective proton study

Background and purposePatients with Ewing Sarcoma (EWS) are treated with multimodality therapy which includes radiation therapy (RT) as an option for local control. We report on the efficacy after proton radiation therapy (PRT) to the primary site for localized and metastatic EWS. Materials and methodsForty-two children with EWS (33 localized, 9 metastatic) treated between 2007 and 2020 were enrolled on 2 prospective registry protocols for pediatric patients undergoing PRT. PRT was delivered by passive scatter (74 %), pencil-beam scanning (12 %) or mixed technique (14 %). Treated sites included the spine (45 %), pelvis/sacrum (26 %), skull/cranium (14 %), extraosseous (10 %), and chest wall (5 %). Median radiation dose was 54 Gy-RBE (range 39.6–55.8 Gy-RBE). Patients with metastatic disease received consolidative RT to metastatic sites (4 at the time of PRT to the primary site, 5 after completion of chemotherapy). Median follow-up time was 47 months after PRT. ResultsThe 4-year local control (LC), progression-free survival (PFS), and overall survival (OS) rates were 83 %, 71 %, and 86 %, respectively. All local failures (n = 6) were in-field failures. Tumor size ≥ 8 cm predicted for inferior 4-year LC (69 % vs 95 %, p = 0.04). 4-year PFS and OS rates were not statistically different in patients with localized versus metastatic disease (72 % vs 67 %, p = 0.70; 89 % vs 78 %, p = 0.38, respectively). ConclusionIn conclusion, LC for pediatric patients with EWS treated with PRT was comparable to that of historical patients who received photon-RT. Tumor size ≥ 8 cm predicted increased risk of local failure. Patients with metastatic disease, including non-pulmonary only metastases, received radiation therapy to all metastatic sites and had favorable survival outcomes.

Research on proton displacement damage effects in charge-domain accumulation type TDI CMOS image sensors

TDI CMOS image sensors are the most widely used photodetectors in space earth observation and multispectral imaging. The displacement damage caused by high-energy proton irradiation in the space environment leads to the continuous degradation of TDI CMOS image sensor parameters, seriously affecting its performance, reliability, and service life. This paper focuses on a space-based TDI CMOS image sensor chip and carries out 3 MeV proton irradiation tests and post-irradiation annealing tests to obtain the change rules of optical and electrical parameters. The degradation mechanism of sensitive parameters of TDI CMOS image sensors caused by proton irradiation is analyzed, and the sensitive region of proton displacement damage are discussed. The study demonstrates that after proton irradiation, the parameters especially full well capacity and temporal dark noise of the device degrade less, with small sensitivity to proton irradiation. However, the dark current, CTE, and pixel column FPN significantly degrade, and the degree of degradation is linearly related to the proton irradiation dose. In addition, the test also obtained the short-term and long-term annealing changes of sensitive parameters after proton irradiation of TDI CMOS image sensors, providing scientific advice for TDI CMOS image sensors space proton radiation effect tests and evaluations. The research results of this paper provide important references for the evaluation of radiation effects, on-orbit performance estimation, and radiation resistance reinforcement of space-based TDI CMOS image sensors.

РАДИАЦИОННО-ЗАЩИТНЫЙ КОМПОЗИЦИОННЫЙ МАТЕРИАЛ НА ОСНОВЕ ОТХОДОВ РУДНЫХ МИНЕРАЛОВ И КАМНЕПЕРЕРАБОТКИ

Abstract. The relevance of the research topic lies in the fact that currently there is a steady tendency to increase the amount of electromagnetic radiation (EMR) occurring in the human environment, which negatively affects the healthy indoor environment and determines the focus of experimental research on protecting humans from factors hazardous to health. This article is devoted to the possibility of creating radioprotective building materials from man-made waste from various deposits of Armenia. Research is aimed at creating a comfortable living area inside buildings through the development of radioprotective sandwich-type materials that reduce the impact of EMR on human health. Work was carried out in the direction of developing samples of radio-absorbing structures and selecting radio-absorbing fillers. The laboratory obtained samples from stone processing waste and waste from the extraction of ore minerals with a density from -1500 to 2000 kg/m3, as well as samples based on expanded perlite and a mineral binder with a density of 250-300 kg/m3 as an internal heat-insulating layer and transferred to the National Scientific Laboratory named after A.I.Alikhanyan (Yerevan Institute of Physics) for proton irradiation. In this work, the samples were subjected to proton irradiation, since it is a component of cosmic radiation, as well as EMR and is capable of penetrating through layers of matter depending on its composition and properties. Some physical and mechanical properties of the resulting materials, such as compressive strength and water absorption, were also studied. In addition, the article contains a review of foreign experience in obtaining radioprotective materials with various types of radiation. At this stage, only proton irradiation has been studied, but work in this direction continues. 
 Subject of study: development of radioprotective materials of the “sandwich” type.
 Materials and methods: waste of aluminosilicate rocks (tuffs) and waste from the extraction of ore minerals were used. The method of proton irradiation of the obtained materials was used.
 Results: radioprotective materials have been developed that reduce EMR.
 Conclusions: The possibility of obtaining radioprotective materials by introducing ore mineral mining waste into the composition of the composite material has been confirmed.

Radiation hardness of ultrabroadband spintronic terahertz emitters: En-route to a space-qualified terahertz time-domain gas spectrometer

The radiation hardness of ultrabroadband spintronic terahertz emitters against γ and proton irradiation is investigated. We find that irradiation doses equivalent to those experienced by a space instrument en-route to and operated on Mars have a minor effect on the performance of the emitters. In particular, the ultrawide emission spectrum ranging from 0.1–30 THz, which covers a large part of the vibrational fingerprint region, remains unchanged. These results make this emitter type highly interesting as an essential building block for broadband gas sensors based on terahertz time-domain spectroscopy for future space missions.

Effect of proton irradiation on the sensitivity of CO2 sensors based on SnO2 and SnO–SnO2 heterojunctions

Gas sensors are integral to space exploration and development projects. However, few studies have examined the effects of proton irradiation on the performance of semiconductor gas sensors. This study fills this gap by investigating the effect of proton irradiation on the sensitivity of CO2 semiconducting sensors, specifically SnO2 and SnO–SnO2 heterojunction types. In SnO2-based sensors, sensitivity was indicated to remain stable at low fluence and increase at higher fluences owing to proton-induced oxygen vacancy formations, mainly. Meanwhile, in SnO–SnO2 heterojunction sensors, it was found to decrease at low fluences and increase significantly at higher fluences owing to changes in the electrical properties of SnO. These findings suggest that proton irradiation can enhance sensor sensitivity, enabling potential applications in radiation-prone environments, such as outer space. This study contributes to the understanding of the effects of proton irradiation on semiconductor gas sensors and paves the way for their development.

ACR-ARS Practice Parameter for the Performance of Proton Beam Therapy

Aim/Objectives/BackgroundThis practice parameter for the performance of proton beam radiation therapy was revised collaboratively by the American College of Radiology (ACR) and the American Radium Society (ARS). This practice parameter was developed to serve as a tool in the appropriate application of proton therapy in the care of cancer patients or other patients with conditions in which radiation therapy is indicated. It addresses clinical implementation of proton radiation therapy, including personnel qualifications, quality assurance (QA) standards, indications, and suggested documentation. MethodsThis practice parameter for the performance of proton beam radiation therapy was developed according to the process described under the heading The Process for Developing ACR Practice Parameters and Technical Standards on the ACR website (https://www.acr.org/Clinical-Resources/Practice-Parameters-and-Technical-Standards) by the Committee on Practice Parameters – Radiation Oncology of the ACR Commission on Radiation Oncology in collaboration with the ARS. ResultsThe qualifications and responsibilities of personnel, such as the proton center Chief Medical Officer or Medical Director, Radiation Oncologist, Radiation Physicist, Dosimetrist and Therapist, are outlined, including the necessity for continuing medical education. Proton therapy standard clinical indications and methodologies of treatment management are outlined by disease site and treatment group (e.g. pediatrics) including documentation and the process of proton therapy workflow and equipment specifications. Additionally, this proton therapy practice parameter updates policies and procedures related to a quality assurance and performance improvement program (QAPI), patient education, infection control, and safety. ConclusionsAs proton therapy becomes more accessible to cancer patients, policies and procedures as outlined in this practice parameter will help ensure quality and safety programs are effectively implemented to optimize clinical care.

Modeling Field Line Curvature Scattering Loss of 1–10 MeV Protons During Geomagnetic Storms

AbstractThe proton radiation belt contains high fluxes of adiabatically trapped protons varying in energy from ∼one to hundreds of megaelectron volts (MeV). At large radial distances, magnetospheric field lines become stretched on the nightside of Earth and exhibit a small radius of curvature RC near the equator. This leads protons to undergo field line curvature (FLC) scattering, whereby changes to the first adiabatic invariant accumulate as field strength becomes nonuniform across a gyroorbit. The outer boundary of the proton belt at a given energy corresponds to the range of magnetic L shell over which this transition to nonadiabatic motion takes place, and is sensitive to the occurrence of geomagnetic storms. In this work, we first find expressions for nightside equatorial RC and field strength Be as functions of Dst and L* to fit the TS04 field model. We then apply the Tu et al. (2014, https://doi.org/10.1002/2014ja019864) condition for nonadiabatic onset to solve the outer boundary L*, and refine our expression for RC to achieve agreement with Van Allen Probes observations of 1–50 MeV proton flux over the 2014–2018 era. Finally, we implement this nonadiabatic onset condition into the British Antarctic Survey proton belt model (BAS‐PRO) to solve the temporal evolution of proton fluxes at L ≤ 4. Compared with observations, BAS‐PRO reproduces storm losses due to FLC scattering, but there is a discrepancy in mid‐2017 that suggests a ∼5 MeV proton source not accounted for. Our work sheds light on outer zone proton belt variability at 1–10 MeV and demonstrates a useful tool for real‐time forecasting.

Feasibility study of CSNS as an ATLAS ITk sensor QA irradiation site

The current ATLAS Inner Detector will undergo a complete upgrade in order to meet the requirements of the High Luminosity Large Hadron Collider (HL-LHC). The new Inner Tracker (ITk) will be made completely of silicon sensors fabricated by Hamamatsu Photonics K.K. (HPK). Quality Assurance (QA) is focused on providing confidence that quality requirements will be fulfilled in production such as irradiation tolerance and testing specification for the mini sensors. The Associated Proton beam Experiment Platform (APEP) beam line at the China Spallation Neutron Source (CSNS) was commissioned in 2022. This study focused on verifying the feasibility of CSNS as an ITk sensor QA irradiation site. A low-temperature Peltier cold box has been developed to keep the irradiation sensor samples at −15 °C. Several fluence points have been studied from 5.1×1014 neq/cm2 to 1.6×1015 neq/cm2, measured with the activation of the aluminium foils. The post-irradiation measurements (IV, CV, and CCE) are done under cold temperatures (−8 °C for IV and CV, −20 °C for CCE), after annealing for 80 min at 60 °C. Test results show CSNS could be a suitable proton irradiation site for the ATLAS ITk sensor project, after formal site qualification.

Synergistic effect of proton irradiation and electrical stress on high-speed 850 nm vertical-cavity surface-emitting lasers

The synergistic effect significantly impact VCSEL's reliability for potential applications in spatial data communication. The synergistic effect of 3 MeV proton irradiation and electrical stress on 850 nm high-speed VCSELs is investigated. The degradation of VCSEL slow down under the influence of bias current. However, device degradation is more pronounced during irradiation under high bias current density. Low frequency noise (LFN) analysis results indicate that defects induced by proton irradiation are the primary cause of the optical-electrical parameter degradation in the device. The bias current density significantly influences the final defect yield, leading to variations in the degree of degradation after irradiation at different bias currents. At a bias current density of 6.03 × 105 A/m2, the degradation of the modulation bandwidth is reduced in comparison to the unbiased state. A mechanism investigation into the synergistic effect of proton irradiation and electrical stress on VCSELs lends support for accurately evaluating the radiation hardness of optical communication system composed of VCSELs in harsh radiation environments.