HCV virus has been shown to induce insulin resistance (IR) itself. The aim of this work: was to evaluate HCV-induced IR in Egyptian HCV cirrhotic patients after LDLT and correlate the occurrence of IR with the level of HCV-RNA viremia and the status of HCV disease recurrence post LDLT. 67 patients had received LDLT from November 2010 to November 2012. 17 of them were included in this prospective research by the following criteria :1) Patients with HCV related End Stage Liver Disease , who were eligible for liver transplantation . 2) Patients with an estimate of IR using HOMA-IR level more than or equal 2 +/- [impaired fasting plasma glucose (FPG) and/or impaired oral glucose tolerance test (OGTT)] .Patients were followed up with the following schedule : FPG , OGTT and HOMA were routinely done 3 , 6 and 12 months post LDLT. HCV RNA level by PCR was performed 1 , 6 and 12 months to follow up the level of viremia post LDLT . Protocol liver biopsies were taken 6 and 12 months post LDLT. The median HOMA value showed reduction during the first year post LDLT , which was not significant at 3 months post LDLT (p value = 0.055) , was highly significant at 6 months post LDLT (p value =0.002) and was again significant at 12 months post LDLT (p value = 0.028) . Recurrence of HCVdisease was documented histologically in 9 patients (52.9%) at 6 months and 10 patients (58.8%) 1 year post LDLT. There was no statistically significant relation between median HOMA values and either level of HCV-RNA viremia or histological recurrence of HCV 6 and 12 months post LDLT. To our knowledge , this is the first study of HCV-induced IR that was conducted on LDLT recipients. HCV-induced insulin resistance is improved 1 year after after LDLT.