There are characteristic anodic shifts in the migration of various human cerebrospinal fluid proteins in meningitides caused by <i>Haemophilus influenzae, Listeria monocytogenes, Pseudomonas aeruginosa, Neisseria meningitidis </i>and <i>Moraxella </i>sp., when studied by the immuno-electrophoresis method. These anodic shifts were found very frequently in prealbumin, albumin and <i>β<sub>1C/</sub>β<sub>1A</sub></i> globulin. However, in other proteins such as acid α<sub>1</sub>-glycoprotein, α<sub>1</sub>-antitrypsin, α<sub>2</sub>-macroglobulin, α<sub>2</sub>-HS-glycoprotein, coeruloplasmin, haptoglobin, transferrin, hemopexin, <i>β</i><sub>2</sub>-glycoprotein-I, IgA and IgM the anodic shifts were found. Such changes were also observed in a case of <i>Listeria monocytogenes </i>meningitis in α<sub>1</sub>-antichymotrypsin, inter-α-trypsin-inhibitor, α<sub>1</sub>-T-glycoprotein and IgE. Besides, the occurrence of unusual proteins in infected cerebrospinal fluid has also been reported.