Protection Program Research Articles

Dyschromatopsia due to welding arcs: An underestimated occupational injury

Welders are at risk of developing dyschromatopsia, a color vision deficiency, due to occupational exposure, including welding arcs. This visual impairment can impact occupational safety and performance but has received limited attention in research. : This study aimed to investigate the prevalence and characteristics of defective color vision among welders exposed to welding arcs. A cross-sectional study was conducted with 52 male welders working in various industries. Demographic and occupational data were collected through a questionnaire. Color vision assessment was performed using Ishihara and Farnsworth Munsell test. Welding exposure data were collected through self-reporting and workplace observations. Chi-square test was used for data analysis. A p-value of less than 0.05 was considered statistically significant. The prevalence of defective color vision among welders was 15.4%. Age, gender, years of experience, and types of welding performed did not significantly influence the prevalence. Welders in the age group of 31-40 years showed a higher prevalence. Inadequate use of eye protection was identified as a barrier to preventing color vision impairments. Defective color vision is a prevalent occupational injury among welders exposed to welding arcs. The study underscores the importance of preventive measures, including proper eye protection and education programs, to reduce the risk of visual impairments and improve occupational safety. Further research is needed to understand the long-term consequences of welding arc exposure on color vision and its impact on worker performance.

Optimalisasi Program Rukun Warga Responsif Gender untuk Mewujudkan Kelurahan Dr.Soetomo Ramah Perempuan dan Peduli Anak

KRPPA (Kelurahan Ramah Perempuan dan Peduli Anak) is an urban village initiative that combines women's protection and empowerment programs with child rights protection and fulfillment programs. The incorporation of gender and child perspectives into the management of governance at the urban village level, urban village development, and community development and empowerment must be carried out in a planned, comprehensive, and sustainable manner in the long term. The purpose of the KRPPA program optimization research is to strengthen community empowerment with a focus on gender and children's rights. The KRPPA program initiated by the ministry aims to support the developmental needs of children in Kelurahan Dr. Soetomo, tailored to their specific needs. Kelurahan Dr. Soetomo collaborates in the implementation of KRPPA, one of which is through the socialization of Gender Responsive RW. By involving various parties such as parents and local government, this program has succeeded in creating a safe and supportive environment for children's development. The KRPPA assessment has 10 indicator scores that must be met. This comprehensive approach has shown the extent to which Kelurahan Dr.Soetomo has achieved a women- and child-friendly village. The method applied in the community service program in Dr. Soetomo Village, Tegalsari District, Surabaya City is Community Based Research (CBR). The stages carried out include the initial stage and the mentoring stage with the community. Optimization to realize a Women-Friendly and Child-Caring Village maintains RW that have indicated gender responsive RW with a score of 10.

Evaluation of Social Protection Programs to Improve the Welfare of Indonesian Migrant Workers Deported from Malaysia at the Rumah Perlindungan Trauma Center (RPTC) Tanjungpinang, Riau Islands Province

This study aims to evaluate social protection programs to improve the welfare of Indonesian Migrant Workers who are deported from Malaysia who are then provided with social protection services starting from pick-up, shelter at RPTC to repatriation to the area of origin. From the CIPP evaluation model used in this study, it was found: Context evaluation, social protection for migrant workers at RPTC is a crucial step in efforts to improve their welfare. Input evaluation, evaluation of the inputs that have been provided for the social protection of PMI at RPTC aims to measure the extent to which existing resources have been optimally utilized in improving the welfare of PMI which includes human resources, budget, facilities, policies, partnerships and information and data. In the Process Evaluation, researchers focus on activities or agendas that will or have been carried out by RPTC officers/employees. in this case the author found several processes of implementing the agenda, assisting personnel and the supervision process, namely by interviewing, validating the process and filling out questionnaires. Evaluation of results (product) is used to determine what decisions will be made next, the researcher concluded several interviews that said that this social protection service could improve the welfare of Indonesian Migrant Worker.

Does conditional cash transfer deliver? The Indonesian evidence on PKH

Social protection programs aim to secure individuals’ incomes from socioeconomic shocks and provide access to social services for developing human capital and alleviating poverty. In Indonesia, the Family Hope Program (PKH – Program Keluarga Harapan) is a social protection program that focuses on human capital development that requires children’s school enrollment and mothers and toddlers’ health as the conditions of cash transfers. This study seeks to analyze the effects of the PKH program on consumption expenditure, children’s educational attainment, and prenatal visits in Indonesia. We use the 2007 and 2014 IFLS (Indonesian Family Life Survey) survey data analyzed by the difference-in-difference (DID) method. The results demonstrate that PKH has a significantly positive effect on food consumption expenditure. However, PKH has insignificantly negative effects on children’s educational attainment and prenatal visits. The results suggest that the government monitors and ensures that the targeted recipients receive the program’s benefits. As such, the government can enhance the recipients’ awareness of the program’s benefits and ensure the equal availability of supporting infrastructure that enables households to utilize education and health facilities optimally.

The Impact of Socioeconomic Factors on HIV Prevalence and Treatment Accessibility in Nigeria: A Comprehensive Review

HIV/AIDS remained a major public health challenge in Nigeria, with approximately 1.9 million people living with HIV (PLHIV), making it one of the most affected countries globally. This comprehensive review explored the impact of socioeconomic factors on HIV prevalence and treatment accessibility in Nigeria, focusing on key determinants such as poverty, education, gender inequality, and geographic disparities. Poverty exacerbated the risk of HIV infection by limiting access to prevention resources and creating barriers to treatment, while educational disparities affect awareness and prevention behaviors. Gender inequality, particularly in patriarchal societies, increases women’s vulnerability to HIV due to limited control over sexual health decisions and economic dependence. Geographic disparities, especially between urban and rural areas, contributed to uneven HIV prevalence and treatment access, with rural regions often facing significant healthcare infrastructure challenges. Additionally, the strength of health system infrastructure and funding played a crucial role in shaping the effectiveness of HIV services, with underfunding and reliance on external donors posing significant risks to sustainability. The methodology used in this article involved a review and synthesis of existing literature and data on HIV/AIDS in Nigeria, emphasizing the socioeconomic determinants of the epidemic. Addressing these factors required targeted interventions, such as strengthening social protection programs, enhancing education, promoting gender equality, improving healthcare infrastructure, and ensuring sustainable funding. These efforts were essential for reducing HIV prevalence and improving treatment outcomes in Nigeria. Keywords: HIV/AIDS, Socioeconomic determinants, Nigeria, Healthcare infrastructure, Gender inequality.

Role of the CDKL1-SOX11 signaling axis in acute kidney injury.

The biology of the cyclin-dependent kinase-like (CDKL) kinase family remains enigmatic. Contrary to their nomenclature, CDKLs do not rely on cyclins for activation and are not involved in cell cycle regulation. Instead, they share structural similarities with mitogen-activated protein kinases and glycogen synthase kinase-3, although their specific functions and associated signaling pathways are still unknown. Previous studies have shown that the activation of CDKL5 kinase contributes to the development of acute kidney injury (AKI) by suppressing the protective SOX9-dependent transcriptional program in tubular epithelial cells. In the current study, we measured the functional activity of all five CDKL kinases and discovered that, in addition to CDKL5, CDKL1 is also activated in tubular epithelial cells during AKI. To explore the role of CDKL1, we generated a germline knockout mouse that exhibited no abnormalities under normal conditions. Notably, when these mice were challenged with bilateral ischemia-reperfusion and rhabdomyolysis, they were found to be protected from AKI. Further mechanistic investigations revealed that CDKL1 phosphorylates and destabilizes SOX11, contributing to tubular dysfunction. In summary, this study has unveiled a previously unknown CDKL1-SOX11 axis that drives tubular dysfunction during AKI.NEW & NOTEWORTHY Identifying and targeting pathogenic protein kinases holds potential for drug discovery in treating acute kidney injury. Our study, using novel germline knockout mice, revealed that Cdkl1 kinase deficiency does not affect mouse viability but provides protection against acute kidney injury. This underscores the importance of Cdkl1 kinase in kidney injury and supports the development of targeted small-molecule inhibitors as potential therapeutics.

Recent Research Trends against Skin Carcinoma - An Overview.

Skin cancer is a prevalent and sometimes lethal cancer that affects a wide range of people. UV radiation exposure is the main cause of skin cancer. Immunosuppression, environmental factors, and genetic predisposition are other contributing variables. Fair-skinned people and those with a history of sunburns or severe sun exposure are more likely to experience this condition. Melanoma, squamous cell carcinoma (SCC), and basal cell carcinoma (BCC) are the three main forms. Melanoma poses a bigger hazard because of its tendency for metastasis, while SCC and BCC have limited metastatic potential. Genetic mutations and changes to signalling pathways such as p53 and MAPK are involved in pathogenesis. Early diagnosis is essential, and molecular testing, biopsy, dermoscopy, and visual inspection can all help. In addition to natural medicines like curcumin and green tea polyphenols, treatment options include immunotherapy, targeted therapy, radiation, surgery, and chemotherapy. Reducing the incidence of skin cancer requires preventive actions, including sun protection and early detection programs. An overview of skin cancers, including their forms, pathophysiology, diagnosis, and treatment, highlighting herbal therapy, is given in this review.

The Quest for ‘Common Prosperity’ in China

In early 2021, President Xi Jinping introduced a national goal of achieving “common prosperity,” which aims to reduce the yawning wealth gap between China’s rich and poor. At a time when China’s economy is slowing, the implementation of common prosperity involves an unprecedented effort to maintain domestic stability and social quiescence amid intensifying geopolitical tensions. The party-state has sought to avoid provoking public discontent by pooling regional funds for social protection programs rather than pursuing taxation-based redistribution among social classes.

Spatially clustered type I interferon responses at injury borderzones

Sterile inflammation after myocardial infarction is classically credited to myeloid cells interacting with dead cell debris in the infarct zone1,2. Here we show that cardiomyocytes are the dominant initiators of a previously undescribed type I interferon response in the infarct borderzone. Using spatial transcriptomics analysis in mice and humans, we find that myocardial infarction induces colonies of interferon-induced cells (IFNICs) expressing interferon-stimulated genes decorating the borderzone, where cardiomyocytes experience mechanical stress, nuclear rupture and escape of chromosomal DNA. Cardiomyocyte-selective deletion of Irf3 abrogated IFNIC colonies, whereas mice lacking Irf3 in fibroblasts, macrophages, neutrophils or endothelial cells, Ccr2-deficient mice or plasmacytoid-dendritic-cell-depleted mice did not. Interferons blunted the protective matricellular programs and contractile function of borderzone fibroblasts, and increased vulnerability to pathological remodelling. In mice that died after myocardial infarction, IFNIC colonies were immediately adjacent to sites of ventricular rupture, while mice lacking IFNICs were protected from rupture and exhibited improved survival3. Together, these results reveal a pathological borderzone niche characterized by a cardiomyocyte-initiated innate immune response. We suggest that selective inhibition of IRF3 activation in non-immune cells could limit ischaemic cardiomyopathy while avoiding broad immunosuppression.

THE ROLE OF JUSTICE AND EQUALITY IN SOCIETY AND THEIR IMPACT ON MEDICINE

Justice and equality play a central role in the development of a just and sustainable society. This article examines their role in the field of healthcare and their impact on the availability and quality of medical care. Various aspects of equity in medicine are analyzed, such as equal access to healthcare for all citizens, adequate allocation of medical resources and reduction of inequality in access to medical care. Measures and policies aimed at achieving a more equitable and equitable health care system are being considered, including the development of social protection programs, and improving the availability and quality of medical care for marginalized groups. As a result, the article emphasizes the need to create a fair healthcare system where every citizen has equal opportunities to receive the necessary medical care, regardless of their status and circumstances.

An Investigation on the Effect of Savings and Internal Lending Communities Participation on Poverty Reduction among Informal Operators in Shangai Informal Settlement Mpika, Zambia

Social protection comprises policies and programmes that are put in place in order to reduce the lifelong consequences that negatively affect society's well-being. About 4 billion people around the world are not on social protection programmes provided by the government (ILO, 2020). They are either on private formal or traditional and informal mechanisms such as Savings and Internal Lending Communities (SILC). The participation in SILC in several studies has indicated that the participants had alleviated poverty through asset accumulation. However, the effect of SILC participation by informal operators in Shangai informal settlements on poverty reduction has not been documented, hence this study. The specific objectives of the study were to characterize and determine the effect of Savings and Internal Lending Communities' participation in poverty reduction among informal operators in Shangai informal settlements. The study employed a descriptive research design with a sample size of 112 randomly selected. Questionnaires were used to collect quantitative data. The quantitative data was analyzed and presented as means, frequency and percentages. Examination of the effects of SILC participation and poverty reduction was done using an independent t-test and Binary logistic regression with a p<0.05 as a criterion of Statistical significance. Results showed that participation in SILC led to poverty reduction through the accumulation of sponge mattresses and beds. Therefore, this study recommends that the government build SILC groups as viable social protection coverage for the informal sector.

Nurse Attrition: Content Analysis of Free-Text Responses From Two Military Nursing Practice Environment Surveys.

Staff nurse attrition negatively impacts readiness of the warfighter and the health and wellbeing of all beneficiaries of the Military Health System (MHS). To promote the retention of a robust nursing workforce, a complete understanding of nurses' perceptions regarding their intent to leave is necessary. The purpose of this study was to explore the free-text responses of 1,438 nurses working among military medical treatment facilities for factors influencing their intent to leave, as an indicator of potential turnover, or attrition. This study employed thematic analysis to investigate the qualitative responses from the 2016 and 2018 Military Nursing Practice Environment Surveys. The study was determined to be exempt from Institutional Review Board review through the Womack Army Medical Center's Human Research Protection Program. Findings indicate that leadership and management (n = 647), staffing (n = 353), career opportunities (n = 345), staff outcomes (n = 247), culture (n = 153), quality of care (n = 99), patient care barriers (n = 86), non-patient care activities (n = 79), lack of formal professional development (n = 75), and area or care environment (n = 67) were among the top factors influencing staff nurse intent to leave, respectively. Our findings support the evaluation of retention strategies using implementation science for nurses and nurse resource personnel (e.g., nursing assistants, technicians, medics, and corpsman) to ensure a robust nursing work force throughout the MHS. Staff nurses and resource personnel working among military treatment facilities and embedded in units supporting combat and humanitarian missions ensure access to care and health promotion of the warfighter and all MHS beneficiaries.

Environmental protection laws and regulations in healthcare

The European Union and the German federal government have initiated aclimate protection program with guidelines and laws that, for the first time, hold the healthcare sector accountable. The legal provisions have far-reaching implications for hospitals. This article presents the specific provisions to be observed and the best practices for implementing the necessary measures. This study aims to provide aconcise overview of the legal provisions to be observed in the healthcare sector and to highlight support services for implementation. Selective internet research on legal provisions for the healthcare sector and guidance on approach. The EU Corporate Sustainability Reporting Directive (CSRD) with taxonomy came into force on January5, 2023. The Climate Protection Act, which was amended in April 2024, the Energy Efficiency Act (EnEfG), which came into force in January 2024, and the Supply Chain Sustainability Obligations Act (LKSG) are the most important German legal frameworks to be observed. The EU regulations and the German government's laws pose new challenges for hospitals, but are also an opportunity to tackle the necessary measures to reduce greenhouse gas equivalents in astructured manner. Achieving climate neutrality by 2045 is in everyone's interest and can only succeed if all sectors contribute. The healthcare sector has not yet been held accountable, despite its significant contribution of approximately 5% to national greenhouse gas emissions. The legal provisions now trigger anecessary transformation but also pose challenges in day-to-day operations, requiring support services.

How Can Ecological Product Value Realization Sustainably Enhance the Well-Being of Farmers? A Case Study of Xingyuan Village in China

Although recent years have witnessed a considerable increase in studies on the economic value of ecological products, the extant literature has overlooked the multidimensional enhancement of ecological product value from the perspective of farmers’ well-being. This research aims to examine how the Realization of Ecological Product Value (EPVR) serves as a crucial pathway to promoting the overall well-being of farmers in developing countries. Through a case study of a village in southeastern China, this research reveals that EPVR can enhance farmers’ well-being via various mechanisms as follows: (1) Economic solution to enrich farmers’ livelihood diversity, achieved by leveraging rural resource endowments and comparative advantages; (2) Fair social protection program enabling farmers to enjoy ecological benefits and further achieving urban-rural integration; (3) Environmental protection plan that balances production, living, and ecology; and (4) Grassroots governance tool promoting the governance ability to form collaborative governance model in a community of shared interests. This study offers theoretical support for enhancing human well-being through the realization of ecological product value in rural areas.

Research into the Correlation between Carbon Emissions, Foreign Energy Investment, and China’s Financial Advancement

Carbon dioxide emissions are the primary driver of global climate change. This study aims to analyze the relationship between inward foreign direct investment in the energy sector and CO2 emissions in China versus other countries. For this, the co-integration methods were used. The results suggested that China should encourage the adoption of green technologies in order to reduce CO2 emissions and enforce strict environmental laws. Another necessary step is to stop the licensing of polluting industries that emit high amounts of CO2 emissions. The present findings can be used to develop state programs for environmental protection. Future research can examine the relationship of FDI in the energy sector with indicators other than pollution with CO2 emissions, for example, with the consumption of renewable energy sources.

Toxicity reference values for force health protection: Provisional occupational exposure guidelines

Force Health Protection programs in the U.S. Air Force endeavor to sustain the operational readiness of the warfighters. We have previously identified hundreds of chemical substances of interest and toxicity reference value (TRV) knowledge gaps that constrain risk based-decision-making for potential exposures. Multiple approaches to occupational TRV estimation were used to generate possible guideline values for 84 compounds (18% of the substances of interest). These candidate TRVs included values from international databases, chemical similarity (nearest neighbor) approaches, empirical adjustments to account for duration differences, quantitative activity relationships, and thresholds of toxicological concern. This present work describes derivation of provisional TRVs from these candidate values. Rodent bioassay-derived long-term worker Derived No-Effect Levels (DNELs) were deemed presumptively the most reliable, but only 19 such DNELs were available for the 84 substances with TRV gaps. In the absence of DNELs, the quality of the approaches and consistency among candidate values were key elements of the weight of evidence used to select the most suitable guideline values. The use of novel nearest-neighbor approaches, empirical adjustment of short term TRVs, and occupational exposure bands were found to be options that would allow occupational TRV estimation with reasonable confidence for nearly all substances evaluated.

The Relationship between Economics and Social Welfare: A Study of the Impact of the Economic Crisis on Society

Economic crises often have a significant impact on people's social well-being, especially in the context of declining incomes, increasing unemployment, and economic instability. This research aims to explore the relationship between economic conditions and social welfare by focusing on the impact of the economic crisis on people's lives. Through a qualitative approach with a literature study method, this study analyzes various secondary data sources, including research reports, journal articles, and policy documents related to economic crises and social welfare. The results of the study show that the economic crisis contributes to the decline in social welfare by increasing inequality, decreasing the quality of life, and affecting people's mental health. The findings also reveal that appropriate policy responses and effective social protection programs can mitigate the negative impact of the economic crisis on social welfare. Thus, this study emphasizes the importance of coordinated policy interventions to strengthen community social resilience in the face of economic crises.

Toxicity reference values (TRVs) for force health protection: Gap identification and TRV prediction

The mission of the Force Health Protection (FHP) program of the U.S. Air Force (USAF), sustaining the readiness of warfighters, relies on determinations of acceptable levels of exposure to a wide array of substances that USAF personnel may encounter. In many cases, exposure details are limited or authoritative toxicity reference values (TRVs) are unavailable. To address some of the TRV gaps, we are integrating several approaches to generate health protective exposure guidelines. Descriptions are provided for identification of chemicals of interest for USAF FHP (467 to date), synthesis of multiple TRVs to derive Operational Exposure Limits (OpELs), and strategies for identifying and developing candidate values for provisional OpELs when authoritative TRVs are lacking. Rodent bioassay-derived long-term Derived No Effect Levels (DNELs) for workers were available only for a minority of the substances with occupational TRV gaps (19 of 84). Additional occupational TRV estimation approaches were found to be straightforward to implement: Tier 1 Occupational Exposure Bands, cheminformatics approaches (multiple linear regression and novel nearest-neighbor approaches), and empirical adjustment of short term TRVs. Risk assessors working in similar contexts may benefit from application of the resources referenced and developed in this work.

The sediment of a river having ‘’good ecological status” turned out to be toxic to midge Chironomus riparius larvae: Implication for environmental monitoring?

Globally, monitoring of the surface waters is largely limited to the physico-chemical analysis of water in rivers and lakes. Sediment state in the aquatic systems including sediment chemical content or the structure and diversity of benthic communities or ecotoxicological studies with natural sediments remains largely overlooked by the monitoring programs. Hence we assessed the potential toxicity of three riverine sediments on the life-cycle traits (emergence and reproduction) of midge Chironomus riparius via an ecotoxicological testing method over two generations (according to OECD test 233 guidelines). In addition, the riverine sediments were spiked with polyamide (nylon) microplastic particles (1 g kg−1) to analyze an additive effect of microplastic on the sediment toxicity. As model river systems, three rivers (Karchaghbyur, Gavaraget, Argichi) in the Lake Sevan basin (Armenia) were selected. Results of ecotoxicity testing were compared with the indices of water quality (derived from the physico-chemical analysis) and the indices of the ecological status of the rivers (derived from the analysis of benthic communities). The results of testing demonstrated an unexpectedly low emergence of midges after the first generation exposed to the sediment of the river having ‘’good ecological status’’ - the Argichi. Sediments of the Karchaghbyur and Gavaraget rivers impeded the emergence and reproduction of midges after the second generation. An addition of polyamide particles to the sediments did not significantly affect the life-cycle traits of C. riparius indicating the primary effect of the sediments’ condition. The discrepancy of biotesting result with that of the other two methods (which indicated ‘’average water quality’’ and “good ecological status”) underlies the importance of designing more comprehensive monitoring programs for better assessment and protection of aquatic systems and resources.

Genetic and Phytopathogenic Characterization of Endemic Colletotrichum Isolates in Major Olive Cultivars of Greece

Olive anthracnose outbreaks caused by the Colletotrichum species complex in the Mediterranean region decrease both fruit yield and olive oil production while also drastically degrading olive oil quality. The presence of various Colletotrichum species able to produce disease symptoms in olive fruits significantly deteriorates the efforts for an efficient crop protection strategy. In this report, the major olive productive area of Peloponnese was screened for Colletotrichum species capable of generating anthracnose symptoms. Olive fruits of 12 different olive cultivars were collected from 60 groves distributed analogously in the Peloponnese. Thirty-two fungal strains isolated from asymptomatic olive drupes were identified morphologically as Colletotrichum spp. and were multilocus genetically analyzed. The 32 isolates were grouped into two primary lineages resembling the previously characterized Colletotrichum acutatum and Colletotrichum nymphaeae based on the conducted genetic analysis for five genetic loci. The virulence of 16 Colletotrichum spp. strains were evaluated in a detached fruit assay of 10 Greek olive cultivars. The results clearly suggested that fungal isolates belonging to both C. acutatum and C. nymphaeae exhibited different levels of pathogenicity in a cultivar-dependent manner. Thus, cultivars examined in terms of the % Disease Index (%DI) were divided into highly tolerant, tolerant, and susceptible, and those analyzed regarding the % Disease Severity Index (%DSI) were divided into tolerant and susceptible. Our results suggest that the Greek cultivars of Athinolia and Megaritiki are highly tolerant to the vast majority of Colletotrichum strains isolated from Peloponnesian groves and consist of a significant genetic material for the future design of crop protection programs against anthracnose breakouts.