A series of biodiversity conservation campaign since 1980s and the establishment of Siberut National Park on Siberut Island (West Sumatra, Indonesia) have seriously unsettled the relationship between the Mentawai and forest as well as between the Mentawai with powerful external agencies. For the Mentawai, forest and nature should be managed and utilized. Claiming and contesting forests have been part of the Mentawai social fabric and histories, while cultivating and transforming them into social spaces (agroforest, sago garden, settlements) and extracting uncultivated animals and plants are valued human activities and important criteria in the construction of Mentawai personhood. The park has tried to persuade people keeping the forest intact and not using and transforming it. The establishment of the park also implies that the state claims the land and the forest. This paper argues that establishing a national park and protecting forests contradicts the value of productive activities and the history of human labour attached and spent on the land and forest. The resistance over forest protection offers vital clues in understanding how producing nature is inseparable from producing humans and discusses how people can coexist with forests and nonhuman entities, not just by conserving it, but by transforming it. Understanding the mutual production and transformation of human nature is crucial to the future of biodiversity conservation activities on the island.