Statistical analysis of certain major diseases lethal to the animal was carried out through on-spot investigations and consultations to related documentary materials. The results show that the first serious lethal factor is digestive system diseases. Next comes malnutrition and organic exhaustion. In order of decremental percentages, other diseases are roundworm disease, epilepsy, toxicosis, pneumonia, tumor, pericarditis, etc.. In relation to 54 wild giant pandas taken for statistics, the death of malnutrition, organic exhaustion caused accounts for 42.78%. In order of reducing percentages, other diseases are roundworm disease, toxicosis, epilepsy, etc.. Based on the statistics of 22 penned giant pandas, the death out of the digestive system diseases comes first, accounting for 63.64%. Other diseases in order of decremental proportion are epilepsy, organic exhaustion, etc., Gastroenteric hemorrhage is one of the highest mortality in digestive system diseases, the next comes orderly roundworm disease, hemorrhage, gatroenteritis and intestinal obstruction. The mortality of the sub-adults is the highest, accounting for 64.29%, or 2.6 times as that of the adults, or 7 times as that of the aged giant pandas. Some prevention measures of diseases for Giant pandas were also discussed in this paper.